Search results for "etica."
showing 10 items of 13546 documents
Oncogenic BRAF and p53 Interplay in Melanoma Cells and the Effects of the HDAC Inhibitor ITF2357 (Givinostat)
2023
Oncogenic BRAF mutations have been widely described in melanomas and promote tumour progression and chemoresistance. We previously provided evidence that the HDAC inhibitor ITF2357 (Givinostat) targets oncogenic BRAF in SK-MEL-28 and A375 melanoma cells. Here, we show that oncogenic BRAF localises to the nucleus of these cells, and the compound decreases BRAF levels in both the nuclear and cytosolic compartments. Although mutations in the tumour suppressor p53 gene are not equally frequent in melanomas compared to BRAF, the functional impairment of the p53 pathway may also contribute to melanoma development and aggressiveness. To understand whether oncogenic BRAF and p53 may cooperate, a po…
Análisis farmacocinético-farmacodinámico poblacional de un nuevo fármaco de origen marino en pacientes con cáncer
2017
ANÁLISIS FARMACOCINÉTICO-FARMACODINÁMICO POBLACIONAL DE UN NUEVO FÁRMACO DE ORIGEN MARINO EN PACIENTES CON CÁNCER Uno de los mayores retos al analizar la eficacia y la seguridad de un nuevo fármaco en oncología es la gran variabilidad en la respuesta al tratamiento. Asimismo, la variabilidad en la farmacocinética y en farmacodinamia hace que pacientes no necesariamente alcancen la misma respuesta. Por tanto, es necesario conocer y explicar las distintas fuentes de variabilidad en la respuesta farmacológica para alcanzar una utilización óptima del fármaco. El nuevo fármaco objeto de la de Tesis Doctoral, es un agente antineoplásico en desarrollo clínico, aislado de un molusco marino y cuya p…
NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials
2019
ObjectiveWe conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of NMDA receptor (NMDAR) antagonists.MethodsSix major databases were systematically searched (to March 2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis.ResultsSearches identified 70 eligible trials (n = 1,069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in hyperalgesic area (standardized mean difference 0.54, 95% confidence interval [CI] 0.34, 0.74, p < 0.001) and a 1.2-point decr…
Identification of Brassicadiene, a Diterpene Hydrocarbon Attractive to the Invasive Stink Bug Bagrada hilaris, from Volatiles of Cauliflower Seedling…
2020
Brassicadiene, a novel tricyclic diterpene hydrocarbon, was identified by a combination of mass spectrometry, microchemical tests, and analysis of NMR spectra. The compound constitutes >90% of the volatile organic compounds produced by cauliflower seedlings, Brassica oleracea var. botrytis. The invasive stink bug Bagrada hilaris is strongly attracted to brassicadiene, providing a mechanism for this herbivore, which specializes on cruciferous plants, to locate its hosts in a nutrient-rich and vulnerable stage.
Etica del dono e fondamento della comunità
2009
Comparative Analysis of Nuclear Matrix Elements of 0νβ+β+ Decay and Muon Capture in 106Cd
2021
Comparative analyses of the nuclear matrix elements (NMEs) related to the 0νβ+β+ decay of 106Cd to the ground state of 106Pd and the ordinary muon capture (OMC) in 106Cd are performed. This is the first time the OMC NMEs are studied for a nucleus decaying via positron-emitting/electron-capture modes of double beta decay. All the present calculations are based on the proton-neutron quasiparticle random-phase approximation with large no-core single-particle bases and realistic two-nucleon interactions. The effect of the particle-particle interaction parameter gpp of pnQRPA on the NMEs is discussed. In the case of the OMC, the effect of different bound-muon wave functions is studied. peerRevie…
Il senso della paternità nel pensare di Marìa Zambrano
2017
The paper, highlighting some stages of María Zambrano biographical and speculative pathway, aims at offering a pedagogical reflection on the value of fatherhood as specific formative relationship. The comparison with life and with the thought of this Andalusian thinker also makes a reviewing of some of the contemporary educational challenges possible.
Kairós. Un tempo nel mezzo. Percorso multidisciplinare di analisi dell’esperienza di assistenza ai pazienti oncologici terminali
2011
La concezione personalistica cristiana permette una corretta visione antropologi- ca ed etica che fonda le riflessioni delle scienze umane (sociologia, psicologia, pedagogia, scienze della comunicazione) che vogliono analizzare le situazioni in cui versano il paziente oncologico terminale, i suoi familiari e coloro che si occupano dell’attività di assistenza clinico-sanitaria, sociale e volontaria. Se- condo tale concezione, la “persona” è un’unità inscindibile di corpo, psiche e spirito, di sesso maschile e femminile, destinata a una dimensione trascendente e ultraterrena dell’essere. La persona ammalata di cancro, in questa visione, non può essere ridotta a mero agglomerato psicofisico, a…
Impact of Ageing on Pea Protein Volatile Compounds and Correlation with Odor
2022
Vegetal proteins are of high interest for their many positive aspects, but their ‘beany’ off-flavor is still limiting the consumer’s acceptance. The aim of this work was to investigate the conservation of pea protein isolate (PPI) during time and especially the evolution of their organoleptic quality under two storage conditions. The evolution of the volatile compounds, the odor and the color of a PPI has been investigated during one year of storage. PPI was exposed to two treatments mimicking a lack of control of storage conditions: treatment A with light exposition at ambient temperature (A—Light 20 °C) and treatment B in the dark but with a higher temperature …
La categoría de la vitalidad en el último Croce
2015
La divergencia entre realidad histórica e ideal moral, es decir, la lucha entre fuerzas vitales y fuerzas morales, es una de las preocupaciones fundamentales de la filosofía del último Croce. Para ello parte de una aguda crítica al extremo vitalismo que condujo a la II Guerra Mundial, considerado no como fuerza categorial del espíritu, sino como una fuerza identificable con la irracionalidad de puro impulso individual. En este contexto, cobra relevancia su pensamiento en torno a la religión y su relación con el estado, así como el descubrimiento del sufrimiento, o mejor dicho, de la ética como sufrimiento, que sustituye el previo “descubrimiento de lo útil” como otra y más profunda clave pa…