Search results for "etica"
showing 10 items of 14083 documents
Intergenerational Effect of Early Life Exposure to Permethrin: Changes in Global DNA Methylation and in Nurr1 Gene Expression
2015
Environmental exposure to pesticides during the early stages of development represents an important risk factor for the onset of neurodegenerative diseases in adult age. Neonatal exposure to Permethrin (PERM), a member of the family of synthetic pyrethroids, can induce a Parkinson-like disease and cause some alterations in striatum of rats, involving both genetic and epigenetic pathways. Through gene expression analysis and global DNA methylation assessment in both PERM-treated parents and their untreated offspring, we investigated on the prospective intergenerational effect of this pesticide. Thirty-three percent of progeny presents the same Nurr1 alteration as rats exposed to permethrin i…
Su alcune questioni riguardanti la responsabilità morale nei confronti degli embrioni umani, “Bioetica. Rivista interdisciplinare” XVIII, 2/2010, pp.…
2010
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)
2021
© 2021 by the authors.
Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain
2020
This article belongs to the Special Issue Bacteriophage—Molecular Studies.
New Evidence of the Enhanced Elimination of a Persistent Drug Used as a Lipid Absorption Inhibitor by Advanced Oxidation with UV-A and Nanosized Cata…
2019
This work demonstrates new evidence of the efficient destruction and mineralization of an emergent organic pollutant using UV-A and titanium nanosized catalysts. The target compound considered in this work is the primary metabolite of a lipid regulator drug, clofibrate, identified in many studies as refractory during conventional wastewater treatment. The photocatalytic performance study was carried out in batch mode at laboratory scale, in aqueous suspension. Kinetic data showed that titanium dioxide P25 Aeroxide® exhibits the highest photocatalytic efficiency compared to the other investigated catalysts. Pollutant degradation and mineralization efficiencies strongly increased when decreas…
La caracterización de Fadrique (Fadrique Furio Ceriol) en la Philosophia Antigua Poética de Alonso López Pinciano
2021
Abordamos en este trabajo la caracterización del personaje de Fadrique en la Philosophia Antigua Poetica y su identificación con el humanista valenciano Fadrique Furio Ceriol. A través de esta caracterización nos aproximaremos a los rasgos personales y vitales, sus actividades y participación en algún círculo literario en los últimos 10 años de su vida. In this work we address the characterization of the character of Fadrique in the Philosophia Antigua Poetica and his identification with the Valencian humanist Fadrique Furio Ceriol. Through this characterization we will approach his personal and vital traits, his activities and his proximity to a literary circle in the last 10 years of his …
Fonētisko traucējumu korekcija 4 gadus veciem bērniem rotaļās
2020
Darba nosaukums: Fonētisko traucējumu korekcija 4gadus veciem bērniem rotaļās Darba autors: Tatjana Brahmane Darba mērķis: Teorētiski izzināt un praktiski pārbaudīt fonētisko traucējumu novēršanas iespējas vingrinājumos un rotaļās 4 gadus veciem bērniem. Pirmajā nodaļā autore ir analizējusi un pētijusi dažādu autoru teorētiskās atziņas par runas un valodas kopsakarībām un 4 gadus vecu bērnu attīstību. Otrajā nodaļā tiek dažādu autoru atziņas par rotaļu izmantošanas iespējām fonētisko traucējumu mazināšanā. Trešajā nodaļā tiek atspoguļots eksperimentāli praktiskais pētijums fonētisko traucējumu novēršanai,koriģējoši attīstošā darbā izmantojot rotaļas. Diplomdarba apjoms 74 lpp., ievietoti 11…
P-C Cross-Coupling Onto Enamides: Versatile Synthesis of α-Enamido Phosphane Derivatives
2012
We report herein the Pd-catalyzed P–C cross-coupling reac- tion between enol phosphates and secondary phosphane–bor- ane complexes or phosphane oxides. The reaction was per- formed under mild conditions, owing to Pd activation of the P–H bonds of the phosphane–boranes (or phosphane oxides) and to the powerful enol phosphate coupling reagents. New useful chiral and achiral α - β -alkenylphosphane derivatives bearing an amido group in the α -position to the P center were obtained in yields up to 70 %.
Designing P-Chirogenic 1,2-Diphosphinobenzenes at Both P-Centers Using P(III)-Phosphinites
2016
International audience; A new enantiodivergent synthesis of P-chirogenic 1,2-diphosphinobenzenes (DP*B) bearing the chirality on one or both phosphorus centers is reported using aryne chemistry. The principle is based on successive reactions of 1,2-dibromobenzene with sec-phosphide boranes, then DABCO to remove the borane, and finally with chlorophosphines or P(III)-chirogenic phosphinites. The efficiency of this synthesis was demonstrated by the stereoselective preparation of (S,S)-1,2-bis(o-anisylphenylphosphino)benzene. A comparison of DIPAMP and homochiral DP*B ligands in asymmetric Rh- or Pd-catalyzed reactions was reported.