Search results for "etica"

showing 10 items of 14083 documents

Bcl-xL as a Modulator of Senescence and Aging

2021

Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeling and wound healing. However, constant stresses and a weakening immune system can lead to senescence chronicity with aging. The accumulation of senescent cells is directly related to tissue dysfunction and age-related pathologies. Centenarians, the most aged individuals, should accumulate senescent cells and suffer from their deleterious effects,…

senescenceReviewmedicine.disease_causelcsh:Chemistry0302 clinical medicineImmunologic Surveillancelcsh:QH301-705.5SpectroscopyCellular Senescenceimmunosenescence0303 health sciencesapoptosisGeneral MedicineImmunosenescenceComputer Science ApplicationsCell biologyOrgan Specificity030220 oncology & carcinogenesisDisease SusceptibilitycentenariansProtein BindingSignal TransductionSenescencebcl-X ProteinBcl-xLBiologyCatalysisInorganic Chemistry03 medical and health sciencesImmune systemStress PhysiologicalmedicineAnimalsHumansPhysical and Theoretical ChemistrySenolyticMolecular Biology030304 developmental biologyBcl-xLOrganic ChemistryIntrinsic apoptosisagingGene Expression Regulationlcsh:Biology (General)lcsh:QD1-999senolyticsbiology.proteinWound healingOxidative stressBiomarkersDNA DamageInternational Journal of Molecular Sciences
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Oltre il senso comune. Il concetto di pluralità in Hannah Arendt, tra estetica e politica

senso comune Arendt pluralità estetica politicaSettore SPS/01 - Filosofia Politica
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Senso e comunita'

2012

Associando senso come sensazione e senso come significato concettuale e passando attraverso Aristotele e Hegel, il saggio definisce il 'senso' come unificazione non distruttiva ma salvifica del pensiero con le cose stesse, resa possibile perché l'essere stesso è costitutivamente accessibile e comprensibile, e per questo rende possibile il sapere quale esser presso altro e essere come altro. Il ‘senso’, su questa base, viene ricondotto a una dimensione intrinsecamente accomunante e comunitaria dell’essere, argomentata mediante un percorso che tocca l’essere per la morte e il con-essere in Heidegger, e si conclude con riferimenti a Gadamer e Ricoeur: il senso, alla fine, è l'altro che non si …

senso comunita' alterita'Settore M-FIL/01 - Filosofia Teoretica
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PROGETTO DELLA MANUTENZIONE E RIPRISTINO DEI SENTIERI DEL PARCO DELLE MADONIE. Progetto di Marcello Panzarella e Luigi Piazza

2012

Viene illustrato l'approccio progettuale utilizzato per la progettazione della rete sentieristica del Parco delle Madonie, comprensivo della definizione della segnaletica e delle facilitazioni per il bivacco, il guado o l'attraversamento dei corsi d'acqua da parte degli escursionisti.

sentieristica segnaletica rifugi ponti in legno MadonieSettore ICAR/14 - Composizione Architettonica E Urbana
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Some Investigations on Similarity Measures Based on Absent Words

2019

In this paper we investigate similarity measures based on minimal absent words, introduced by Chairungsee and Crochemore in [1]. They make use of a length-weighted index on a sample set corresponding to the symmetric difference M(x)ΔM(y) of the minimal absent words M(x) and M(y) of two sequences x and y, respectively. We first propose a variant of this measure by choosing as a sample set a proper subset (x, y) of M(x)ΔM(y), which appears to be more appropriate for distinguishing x and y. From the algebraic point of view, we prove that (x, y) is the base of the ideal generated by M(x)ΔM(y). We then remark that such measures are able to recognize whether the sequences x and y share a common s…

sequence comparisonAlgebra and Number TheorySettore INF/01 - Informaticabusiness.industryComputer sciencePattern recognitionsimilarity measuresMinimal absent wordsTheoretical Computer ScienceComputational Theory and MathematicsSimilarity (network science)Artificial intelligencebusinessInformation SystemsFundamenta Informaticae
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Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

2012

WOS: 000306752700042

sesquiterpeneeudesmanolidePharmaceutical ScienceFlowersSesquiterpeneArticleChinese hamsterCell LineAnalytical ChemistryHuman lungInhibitory Concentration 50Tanacetumchemistry.chemical_compoundsesquiterpenesDrug DiscoveryBotanymedicineAnimalsHumansCytotoxic T cellSettore BIO/15 - Biologia FarmaceuticaPhysical and Theoretical ChemistryTanacetum vulgarecytotoxic activityCell ProliferationCell DeathbiologyTraditional medicine<em>Tanacetum vulgare</em>; sesquiterpenes; eudesmanolides; cytotoxic activityeudesmanolidesOrganic ChemistrySettore CHIM/06 - Chimica Organicabiology.organism_classificationIn vitroTanacetum vulgare; sesquiterpenes; eudesmanolides; cytotoxic activitymedicine.anatomical_structurechemistryPhytochemicalChemistry (miscellaneous)Molecular MedicineColorimetryFormazanMolecules; Volume 17; Issue 7; Pages: 8186-8195
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Chromosomal assignment of the ovine hairless (hr) gene by fluorescence in situ hybridization.

2008

Congenital hypotrichosis in mammalian species consists of partial or complete absence of a hair coat at birth. Affected individuals having a partial hair coat at birth may loose it subsequently.The aim of this paper was to physically map the ovine hr gene using fluorescence in situ hybridization (FISH).A preliminary study on an internet data bank (http://www.informatics.jax.org) showed that the regions of the hr gene on murine chromosome 14 and human chromosome 8 present homology with ovine chromosome 2.

sheepSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticohairleFISHovinigene hairlesshairless (hr) genein situ hybridizationcitogeneticahairless (hr) gene;in situ hybridizationgene hairless; ovini; citogenetica
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Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

siRNA deliveryRNase PCellPharmaceutical Science02 engineering and technology010402 general chemistry01 natural sciencesArticleAnalytical Chemistrylcsh:QD241-441EGF; inulin; PEG; siRNA delivery; targeting; tumourlcsh:Organic chemistryEpidermal growth factorNeoplasmsDrug DiscoveryPEG ratioZeta potentialmedicineCopolymerHumansDoxorubicinPhysical and Theoretical ChemistryRNA Small InterferingtargetingEGFDrug CarriersinulinChemistrytumourOrganic ChemistryTransfection021001 nanoscience & nanotechnologyPEG0104 chemical sciencesNanostructuresmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoChemistry (miscellaneous)BiophysicsMCF-7 CellsMolecular Medicine0210 nano-technologymedicine.drugMolecules (Basel, Switzerland)
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Testing and implementing a new approach to estimating interregional output multipliers using input-output data for South Korean regions

2020

Flegg's location quotient (FLQ) is a useful tool for estimating intraregional output multipliers. This paper uses it as one component when estimating interregional multipliers. Using statistical information criteria and official data for 16 South Korean regions, it is found that the best approach is to combine the FLQ with a simple trade model. The paper explains how the proposed procedure can be implemented for both multiple and individual regions, and also how a region-specific value for the unknown parameter δ in the FLQ formula can be determined. Finally, an illustrative case study of one of the regions is carried out.

sijaintiMathematical optimizationalueelliset erotComputer scienceGeography Planning and Development0211 other engineering and technologiestalousmaantiedealuetutkimusInformation Criteria02 engineering and technologyEtelä-KoreaFlegg's location quotient (FLQ)Component (UML)0502 economics and businessinterregional multipliersEarth and Planetary Sciences (miscellaneous)Economic base analysisHardware_ARITHMETICANDLOGICSTRUCTURES050207 economicspanos-tuotosanalyysiinformation criteriaInput/outputgravity model05 social sciencestuloksellisuus021107 urban & regional planninganalyysimenetelmätGravity model of tradeStatistics Probability and UncertaintyGeneral Economics Econometrics and Finance
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Pulicaria glutinosa Extract: A Toolbox to Synthesize Highly Reduced Graphene Oxide-Silver Nanocomposites

2015

A green, one-step approach for the preparation of graphene/Ag nanocomposites (PE-HRG-Ag) via simultaneous reduction of both graphene oxide (GRO) and silver ions using Pulicaria glutinosa plant extract (PE) as reducing agent is reported. The plant extract functionalizes the surfaces of highly reduced graphene oxide (HRG) which helps in conjugating the Ag NPs to HRG. Increasing amounts of Ag precursor enhanced the density of Ag nanoparticles (NPs) on HRG. The preparation of PE-HRG-Ag nanocomposite is monitored by using ultraviolet-visible (UV-Vis) spectroscopy, powder X-ray diffraction (XRD), and energy dispersive X-ray (EDX). The as-prepared PE-HRG-Ag nanocomposities display excellent surfac…

silver nanoparticlesSilverMaterials scienceReducing agentAnalytical chemistryOxideSpectrum Analysis RamanArticleCatalysisSilver nanoparticlePulicariasurface enhance Raman scattering (SERS)law.inventionlcsh:ChemistryInorganic Chemistrysymbols.namesakechemistry.chemical_compoundMicroscopy Electron TransmissionlawnanocompositesGraphitePhysical and Theoretical Chemistrylcsh:QH301-705.5Molecular BiologySpectroscopyNanocompositebiologyPlant ExtractsGraphenegrapheneOrganic ChemistryGeneral Medicinebiology.organism_classificationPulicariaComputer Science Applicationslcsh:Biology (General)lcsh:QD1-999chemistryplant extractsymbolsGraphiteSpectrophotometry UltravioletRaman spectroscopyNuclear chemistryInternational Journal of Molecular Sciences
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