Search results for "etiikka"
showing 10 items of 633 documents
An ecologist’s guide for studying DNA methylation variation in wild vertebrates
2022
The field of molecular biology is advancing fast with new powerful technologies, sequencing methods and analysis software being developed constantly. Commonly used tools originally developed for research on humans and model species are now regularly used in ecological and evolutionary research. There is also a growing interest in the causes and consequences of epigenetic variation in natural populations. Studying ecological epigenetics is currently challenging, especially for vertebrate systems, because of the required technical expertise, complications with analyses and interpretation, and limitations in acquiring sufficiently high sample sizes. Importantly, neglecting the limitations of t…
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
Introduction
2019
The introduction gives a brief overview of some important developments in recent scholarship on René Descartes and Baruch Spinoza. It is argued that there has been a shift of focus, away from Descartes-the-dualist towards an interest in Descartes’ ethics and his conception of the human being as a union of mind and body. This turn has also given rise to new perspectives on the relations between Descartes and Spinoza. After having presented the area of research covered by the volume, the introduction offers short presentations of the individual chapters. These are divided into three parts: the first part focusing on different features of Cartesian persons; the second discussing different aspe…
Risk factors for Lyme disease : A scale-dependent effect of host species diversity and a consistent negative effect of host phylogenetic diversity
2021
Biodiversity can influence disease risk. One example of a diversity-disease relationship is the dilution effect, which suggests higher host species diversity (often indexed by species richness) reduces disease risk. While numerous studies support the dilution effect, its generality remains controversial. Most studies of diversity-disease relationships have overlooked the potential importance of phylogenetic diversity. Furthermore, most studies have tested diversity-disease relationships at one spatial scale, even though such relationships are likely scale dependent. Using Lyme disease as a model system, we investigated the effects of host species richness and phylogenetic relatedness on the…
Genetic and phenotypic divergence in Drosophila virilis and D. montana
2007
Tapahtuuko lajien toisistaan erillään olevien populaatioiden ilmiasuun liittyvien piirteiden eriytyminen populaatioiden geneettisen eriytymisen sivutuotteena vai nopeutuuko tällaisten piirteiden eriytyminen luonnonvalinnan tai seksuaalivalinnan vaikutuksesta? Tätä kysymystä Jarkko Routtu pohti väitöskirjassaan. Routtu tutki maapallon eri puolilta peräisin olevien mahlakärpäskantojen eriytymistä, D. virilis -lajilla koiraan kosintalaulun ja D. montana -lajilla koiraan kosintalaulun sekä siipien ja genitaalien koon ja muodon perusteella.- Erityisesti Drosophila montanalla seksuaalivalinnan vaikutus populaatioiden eriytymiseen on kiinnostavaa, koska tämän lajin naaraat ovat mieltyneet koiraan …
Why is a live chicken banned from the kindergarten? Two lessons learned from teaching posthuman pedagogy to university students
2019
The hierarchical human-centric paradigm has been criticized by various movements of posthuman philosophy because this paradigm forgets and dismisses nonhuman beings and entities: animals, nature, objects, and technology. When I developed a course called ‘Education and Adaptations of Animal Studies’ for university students in 2015, I learned two lessons in practice. First, many humans, pedagogues, and academics want to hold on to their anthropocentric worldview that separates them from other species. Second, in pedagogical practices humans prefer to avoid confronting the violence they do toward animals. In this article, I reflect on these two lessons learned and consider what they tell us ab…
Negotiating Ethics-in-Action in a Long-term Research Relationship with a Young Child
2021
AbstractThis article continues the discussions of relational ethics put forward in Human Arenas in “Arena of Ethics” (Hilppö et al., 2019). Our aim in this article is to explore and discuss relational ethics, as ethics-in-action, in a long-term research relationship with a child. Our question is: How is ethics-in-action negotiated during critical incidents in the construction of a research space that involves a long-term research relationship with a young child? This article is based on a research project that focused on children’s transitions in early childhood education and care (ECEC). These transitions include the transition from home care to ECEC as well as transitions from child group…
Sequence variation and regulatory variation in acetylcholinesterase genes contribute to insecticide resistance in different populations of Leptinotar…
2021
Abstract Although insect herbivores are known to evolve resistance to insecticides through multiple genetic mechanisms, resistance in individual species has been assumed to follow the same mechanism. While both mutations in the target site insensitivity and increased amplification are known to contribute to insecticide resistance, little is known about the degree to which geographic populations of the same species differ at the target site in a response to insecticides. We tested structural (e.g., mutation profiles) and regulatory (e.g., the gene expression of Ldace1 and Ldace2, AChE activity) differences between two populations (Vermont, USA and Belchow, Poland) of the Colorado potato beet…
After the Millennium Development Goals. Remarks on the ethical assessment of global poverty reduction success
2018
The Millennium Development Goals were effective from 2000 to 2015. Statistics show that most of the goals were met, and particularly success in the goal of reducing extreme poverty (MDG1) gained wide recognition. Despite the strong ethical language related to poverty reduction, there has been little analysis of the ethical significance of the MDG achievements. Since statistical and ethical definitions and representations of poverty never completely overlap, conclusions concerning ethical progress are not directly available from the statistics. This article shows how this ethical significance can be analysed and what kinds of controversies and uncertainties relate to the issue. As part of th…
Leadership Manipulation and Ethics in Storytelling
2012
This article focuses on exerting influence in leadership, namely manipulation in storytelling. Manipulation is usually considered an unethical approach to leadership. We will argue that manipulation is a more complex phenomenon than just an unethical way of acting in leadership. We will demonstrate through an empirical qualitative study that there are various types of manipulation through storytelling. This article makes a contribution to the literature on manipulation through leadership storytelling, offering a more systematic empirical analysis and a more nuanced view of the topic than previously existed by outlining how managers engage in manipulative storytelling and what kind of ethics…