Search results for "evaluation methods"

showing 3 items of 33 documents

Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs

2019

Abstract The T cell repertoire is composed of T cell receptors (TCR) selected by their cognate MHC-peptides and naive TCR that do not bind known peptides. While the task of distinguishing a peptide-binding TCR from a naive TCR unlikely to bind any peptide can be performed using sequence motifs, distinguishing between TCRs binding different peptides requires more advanced methods. Such a prediction is the key for using TCR repertoires as disease-specific biomarkers. We here used large scale TCR-peptide dictionaries with state-of-the-art natural language processing (NLP) methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific classifier to predict which TCR binds to which…

lcsh:Immunologic diseases. AllergyComputer scienceevaluation methodsT-LymphocytesT cellImmunologyReceptors Antigen T-CellEpitopes T-LymphocyteTarget peptidePeptide bindingPeptidechemical and pharmacologic phenomenaComputational biologyLigandsSoftware implementationautoencoder (AE)AntigenEvaluation methodsmedicineImmunology and AllergyHumansProtein Interaction Domains and MotifsEpitope specificityAntigensDatabases ProteinOriginal Researchchemistry.chemical_classificationBinding SitesT cell repertoireChemistryRepertoirelong short-term memory (LSTM)T-cell receptorepitope specificitydeep learninghemic and immune systemsmedicine.anatomical_structuremachine learningPeptidesSequence motiflcsh:RC581-607SoftwareProtein BindingSignal TransductionTCR repertoire analysisFrontiers in Immunology
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A Conceptual Framework for Using and Evaluating Web-Based Learning Resources in School Education

2010

Published version of an article from the journal:Journal of Information Technology Education. Also available from the publisher: http://www.jite.org/documents/Vol9/JITEv9p053-079Hadjerrouit743.pdf Web-based learning resources (WBLRs) have provided teachers with a wide range of new teachingexperiences that are not possible in traditional classroom. However, little research has beendone as to which approach to WBLRs is suitable to address issues that are pertinent to learning.This paper proposes a conceptual framework to explore the design and evaluation of WBLRs inschool education. The paper also examines the way in which the framework is used to evaluatestudents? and teachers? perceptions o…

lcsh:LC8-6691Knowledge managementlcsh:Special aspects of educationlcsh:T58.5-58.64General Computer Sciencelcsh:Information technologybusiness.industryComputer scienceVDP::Technology: 500::Information and communication technology: 550Information technology educationEducationWorld Wide WebConceptual frameworkWeb based learningEducational resourcesEvaluation methodsComputingMethodologies_DOCUMENTANDTEXTPROCESSINGElectronic publishingThe InternetVDP::Social science: 200::Education: 280businessGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)School educationJournal of Information Technology Education: Research
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Ocular counterrolling. Some practical considerations of a new evaluation method for diagnostic purposes.

1986

Ocular counterrolling (OCR) data taken from the literature (12 publications) were used to test the best fit (least-square fit) of these measurements with respect to three mathematical models: a sine relation between OCR and the lateral tilt stimulus, a complex cosine-square relation, and a logarithmic relation between OCR gain and tilt. The latter proved to be the best fitting function. On the basis of this model, we attempted to define a physiological transfer function between OCR gain and tilt, which could serve as a reference of normal population, assuming healthy subjects for the investigations applied. Comparison of this physiological range with pathological data demonstrated marked di…

medicine.medical_specialtyBest fittingMathematical modelLogarithmEye MovementsComputer sciencebusiness.industryNormal populationPattern recognitionGeneral MedicineVestibular Function TestsTransfer functionModels BiologicalSurgeryOtolithic MembraneOtorhinolaryngologyComputer Science::Computer Vision and Pattern RecognitionEvaluation methodsmedicineCurve fittingHumansArtificial intelligencebusinessOcular counterrollingActa oto-laryngologica
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