Search results for "evaluation"
showing 10 items of 1974 documents
Towards high-accuracy mass spectrometry of highly charged short-lived ions at ISOLTRAP
2006
Dedicated to H.-J. Kluge on the occasion of his 65th birthday anniversary - Jürgen Kluge Special Issue; Multiply charged ions of stable xenon isotopes from a plasma ion source have been mass-selected by the on-line mass separator ISOLDE/CERN and delivered to the triple-trap mass spectrometer ISOLTRAP. The doubly charged ions that survived the charge-exchange processes during bunching and ion preparation were transferred to a precision Penning trap for mass determination. Mass values were obtained for the isotopes with mass numbers A=126,129,130,136. They are consistent with previous results except for the case of $^{126}Xe$ where a significant deviation from the literature value was found. …
1H-NMR-Based Metabolomics in Autism Spectrum Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome
2022
We recently described a unique plasma metabolite profile in subjects with pediatric acute-onset neuropsychiatric syndrome (PANS), suggesting pathogenic models involving specific patterns of neurotransmission, neuroinflammation, and oxidative stress. Here, we extend the analysis to a group of patients with autism spectrum disorder (ASD), as a consensus has recently emerged around its immune-mediated pathophysiology with a widespread involvement of brain networks. This observational case-control study enrolled patients referred for PANS and ASD from June 2019 to May 2020, as well as neurotypical age and gender-matched control subjects. Thirty-four PANS outpatients, fifteen ASD outpatients, an…
Scientific journals on Education in Spain: evolution and prospects for the future
2014
The Spanish scientific journals on education have experience an exponential growth in recent decades. The reasons are closely related to the supranational policies of university quality assessment, with specific emphasis on research output with "impact". This way, in just twenty years, Spanish journals have become, in detriment of books, in the main channel of communication of the also increasing educational research. In an extremely competitive global context, dominated by Anglo-Saxon culture, the Spanish journals have made a significant improvement in the quality of editorial management processes, in accordance with international quality indicators. However, access to the most recognized …
A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors.
2012
In this study we report the design, synthesis, and biological evaluation of constrained aminopyridinylimidazoles as p38α MAP kinase inhibitors. The frozen analogue approach focused on the pyridinyl unit, using purine bioisosteres as constrained structure analogues. The identification of the most potent bioisostere was followed by a further derivatization to address hydrophobic region II. In combination with C-2 modifications of the imidazole core, we were able to design highly active inhibitors on the p38α MAP kinase. The inhibitor design presented herein represents a promising and highly efficient advancement of recent stages of development in this class of p38 MAP kinase inhibitors. In co…
Site quality evaluation by classification tree: an application to cork quality in Sardinia
2005
Cork harvesting and stopper production represent a major forest industry in Sardinia (Italy). The target of the present investigation was to evaluate the ‘‘classification tree’’ as a tool to discover possible relationships between microsite characteristics and cork quality. Seven main cork oak (Quercus suber) producing areas have been identified in Sardinia, for a total of more than 122,000 ha. Sixty-three sample trees, distributed among different geographical locations and microsite conditions, were selected. A soil profile near each sample tree was described, soil samples were collected and analysed. After debarking, cork quality of each sample tree was graded by an independent panel of e…
A comparative meta-analysis of TEMPS scores across mood disorder patients, their first-degree relatives, healthy controls, and other psychiatric diso…
2016
Background The Temperament Evaluation Memphis, Pisa, Paris and San Diego Auto-questionnaire (TEMPS) is validated to assess temperament in clinical and non-clinical samples. Scores vary across bipolar disorder (BD), major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), borderline personality disorder (BPD) and healthy controls (HCs), but a meta-analysis is missing. Methods Meta-analysis of studies comparing TEMPS scores in patients with mood disorders or their first-degree relatives to each other, or to a psychiatric control group or HCs. Results Twenty-six studies were meta-analyzed with patients with BD (n= 2025), MDD (n=1283), ADHD (n=56) and BPD (n=43), relati…
Work Ability after Breast Cancer: Study of Healthcare Personnel Operating in a Hospital of South Italy
2022
Breast cancer (BrC) treatment can produce disabilities that often impact the quality of daily life and impact the social and working relationships of the patient. This paper looked into the remaining work ability in a group of female healthcare personnel (HCPs) with BrC in Southern Italy. Each HCP was subjected to a medical check, routine blood tests, and a questionnaire on the work ability index (WAI). Of 980 (100%) HCWs undergoing health control, 6% (n = 54) had experienced BRC, and only 66.6% (n = 36) agreed to take part in the study. A total of 28 (78%) were on night shifts. The WAI score was quite low in 5 (13.8%) cases, moderate in 10 (27.7%) cases, good in 14 (38.8%) cases, and excel…
Aspetti valutativi nella costruzione del sistema informativo per la gestione ambientale dell'azienda
2013
This paper deals with the construction of an environmental management oriented corporate information system. A company point of view is adopted and a managerial approach is integrated with an evaluative approach. The work provides a critical reflection on the nature of corporate environmental responsibility and on the contribution of evaluation discipline for environment oriented improving of the traditional economic and financial corporate information system. Corporate management recognizes the principle that governs the activity of a company in the creation of economic value. In production processes, the neg-entropic aspects − relating to produced goods and other tangible and intangible b…
Architecture Enabling Adaptation of Data Integration Processes for a Research Information System
2018
Abstract Today, many efforts have been made to implement information systems for supporting research evaluation activities. To produce a good framework for research evaluation, the selection of appropriate measures is important. Quality aspects of the systems’ implementation should also not be overlooked. Incomplete or faulty data should not be used and metric computation formulas should be discussed and valid. Correctly integrated data from different information sources provide a complete picture of the scientific activity of an institution. Knowledge from the data integration field can be adapted in research information management. In this paper, we propose a research information system f…