Search results for "evidence."
showing 10 items of 1017 documents
Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.
2007
The ubiquitin-proteasome pathway is the main proteolytic system present in the nucleus and cytoplasm of all eukaryotic cells. Apoptosis activation induced by ubiquitin-proteasome pathway inhibition makes the proteasome a new target of anticancer therapy. Bortezomib is the first proteasome inhibitor to be approved by the US FDA; in 2003 as a third line and in 2005 as a second line therapy for the treatment of multiple myeloma only. This review focuses on the use of bortezomib, not only in its therapeutic role but also, more specifically, in its biologic role and discusses the most recent applications of the drug in solid tumors, both at a preclinical and clinical level.
Evidence-based practice (EBP)
2012
A multicriteria extension of the efficient market hypothesis
2021
Challenging the Efficient Market Hypothesis (EMH) has been a recurrent topic for researchers and practitioners since its formulation. Hundreds of empirical studies claim to either prove or disprove the EMH by means of a number of heterogeneous methods. Even though the EMH is usually adjusted to a measure of risk, there is a lack of a formal analysis within a multiple-criteria context. In this paper, we propose a extension of the EMH that accommodates the foundations of multiple-criteria decision analysis. To this end, we rely on a family of parametric signed dissimilarity measures to assess multidimensional performance differences. Since normalization is a critical step in our approach to a…
TREND DI NOTIFICA DELLE PRINCIPALI TOSSINFEZIONI ALIMENTARI IN CALABRIA E SICILIA PRIMA E DOPO L'ABOLIZIONE DEL LIBRETTO DI IDONEITA' SANITARIA PER A…
2012
L'ABOLIZIONE DEL LIBRETTO DI IDONEITA' SANITARIA PER ALIMENTARISTI PUO' AVER INFLUENZATO IL TREND DI NOTIFICA DELLE TOSSINFEZIONI ALIMENTARI? ANALISI…
2011
A proposal for an evidence-based model of the screening for the colorectal carcinoma in an Italian setting
2011
Introduction. The aim of this paper is to improve the feasibility perception of policymakers, health care workers and target population about the cost-effectiveness of the implementation of colorectal screening as Public Health strategy. Methods. Retrospective study by application of a three-step model designed for a local setting in Sicily (Palermo and its Province) in order to distribute Fecal Occult Blood Tests (FOBTs), offer colonoscopy and surgery, by district allocation of pharmacies, public digestive endoscopic centres and oncologic and general surgery units. Mean adherence to consolidated colorectal screening programs in Italy was applied in order to evaluate the feasibility of an o…
Long-term ecology of investors in a financial market
2018
AbstractThe cornerstone of modern finance is the efficient market hypothesis. Under this hypothesis all information available about a financial asset is immediately incorporated into its price dynamics by fully rational investors. In contrast to this hypothesis many studies have pointed out behavioral biases in investors. Recently it has become possible to access databases that track the trading decisions of investors. Studies of such databases have shown that investors acting in a financial market are highly heterogeneous among them, and that heterogeneity is a common characteristic of many financial markets. The article describes an empirical study of the daily trading decisions of all Fi…
We need to appreciate common synanthropic plants before they become rare: Case study in Latgale (Latvia)
2020
Local ecological knowledge holds great potential in contributing to sustainable resource management and conservation activities. For this reason, the authors choose to analyse an ethnobotanical dataset from the Baltic Sea region by exploring the relationship between plants and humans on the basis of three main categories: habitat characteristics, distribution in the wild and plant sensitivity to human impact beyond physical distance. The study provides empirical evidence of widespread usage of so-called common species which are widely distributed in the territory and benefit from human activity. When considering the data via the intensity of use, based on detailed use-reports (DUR), the mai…
The Effects of Taxation on Migration: Some Evidence for the ASEAN and APEC Economies
2010
This paper investigates the effects of taxation on migration. It develops a stylized, two-country model to examine the impact of taxes on labor mobility. The theoretical predictions that taxes affect migration decisions and that educated workers are more responsive to taxation are supported by some empirical evidence for the economies of the Association of Southeast Asian Nations and the Asia-Pacific Economic Cooperation. The empirical application also shows that average tax rates have a larger impact on migration choices than marginal rates. Average tax rates are most important for migrants with secondary education, while marginal rates have a greater influence on the decisions of migrants…
Predictions concerning the use of health care services in Europe by migrants/refugees and the Mig-HealthCare Roadmap & Toolbox
2019
Abstract Based on the multiple levels of research conducted within the project the consortium developed a roadmap & toolbox which includes the following categories: Continuity of information, Language Culture & Communication, Mental Health, Vaccinations, Maternal/child health, Health promotion, Oral health/Dental Care and NCDs while the Toolbox contains tools on these categories in different languages. The roadmap & toolbox is accessible through the project website. In addition, different scenarios, giving a comprehensive picture of the foreseen situation and the evidence-based policies and actions needed to maximize the effective delivery and sensitivity in the service of care …