Search results for "evolvability"
showing 3 items of 23 documents
Transcriptional Rewiring, Adaptation, and the Role of Gene Duplication in the Metabolism of Ethanol of Saccharomyces cerevisiae
2020
Ethanol is the main by-product of yeast sugar fermentation that affects microbial growth parameters, being considered a dual molecule, a nutrient and a stressor. Previous works demonstrated that the budding yeast arose after an ancient hybridization process resulted in a tier of duplicated genes within its genome, many of them with implications in this ethanol “produce-accumulate-consume” strategy. The evolutionary link between ethanol production, consumption, and tolerance versus ploidy and stability of the hybrids is an ongoing debatable issue. The implication of ancestral duplicates in this metabolic rewiring, and how these duplicates differ transcriptionally, remains unsolved. Here, we …
Evolution in Space and Time: The Second Synthesis between Ecology, Evolutionary Biology, and the Philosophy of Biology
2023
Es un hecho sorprendente que para la mayor parte de la biología evolutiva, rara vez hemos estudiado cómo se desarrolla típicamente la evolución en la naturaleza, en ambientes ecológicos cambiantes, en el espacio y el tiempo. Si bien la ecología desempeñó un papel importante en la eventual aceptación del punto de vista de la evolución genética de poblaciones en la síntesis moderna (alrededor de 1918-1950), desempeñó un papel menor en el desarrollo de la teoría evolutiva hasta la década de 1980, cuando comenzamos a estudiar sistemáticamente la teoría de la evolución. dinámica evolutiva de las poblaciones naturales en el espacio y el tiempo. Como resultado, la teoría evolutiva se construyó ini…
Experimental Evolution Reveals a Genetic Basis for Membrane-Associated Virus Release
2021
Many animal viruses replicate and are released from cells in close association to membranes. However, whether this is a passive process or is controlled by the virus remains poorly understood. Importantly, the genetic basis and evolvability of membrane-associated viral shedding have not been investigated. To address this, we performed a directed evolution experiment using coxsackievirus B3, a model enterovirus, in which we repeatedly selected the free-virion or the fast-sedimenting membrane-associated viral subpopulations. The virus responded to this selection regime by reproducibly fixing a series of mutations that altered the extent of membrane-associated viral shedding, as revealed by fu…