Search results for "excess"
showing 10 items of 225 documents
The Mediating Role of Psychological Distress in Excessive Gambling among Young People: A Four-Country Study
2021
Background and aims: Loneliness and a low sense of mastery are associated with excessive gambling, but the underlying processes of these relationships remain unstudied. Because psychological distress can increase vulnerability to excessive gambling, we investigated its mediating role in these relationships among young people. To meet the need for cross-country research, we also observed how these relationships occur in four countries with different cultures. Design, setting, and participants: Demographically balanced cross-sectional survey data were collected from 15–25-year-olds in Finland (n = 1200
Experiences of a poison center with metformin-associated lactic acidosis.
2004
Metformin is widely used in the treatment of type 2 diabetes, though it is recognized to be associated with the risk of lactic acidosis. A case of pronounced lactic acidosis with cardiac arrest (pH 6.60, lactate 17.5 mmol/l, base excess - 30, standard bicarbonate 2.5 mmol/l, core body temperature 27.8 degrees C) is presented in a 61-year-old woman under metformin therapy. The key laboratory abnormalities observed during the intensive care treatment including repeated hemodialysis are described. The patient showed a complete recovery with residually reduced mental capabilities. Furthermore, an explorative data analysis of our poison center database from 1995 until 2003 concerning metformin w…
A data analysis approach to evaluate the impact of the capacity utilization on the energy consumption of wastewater treatment plants
2019
Abstract The reduction of energy consumption in Waste Water Treatment Plants (WWTPs) is a challenge for the scientific community and for the public authorities. A source of excessive energy cost is the mismatching between operational and design inflow (i.e. capacity utilization): this issue is very relevant above all in areas with high demographic seasonality. Consequently, it is really important to have operational decision criteria to evaluate the impact of a low capacity utilization on energy consumption. In order to provide the scientific community and the plant managers with an adequate criterion, we propose a user-friendly methodology to identify critical conditions of capacity utiliz…
TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans.
2012
Epidemiological studies show association between sleep duration and lipid metabolism. In addition, inactivation of circadian genes induces insulin resistance and hyperlipidemia. We hypothesized that sleep length and lipid metabolism are partially controlled by the same genes. We studied the association of total sleep time (TST) with 60 genetic variants that had previously been associated with lipids. The analyses were performed in a Finnish population-based sample (N = 6334) and replicated in 2189 twins. Finally, RNA expression from mononuclear leucocytes was measured in 10 healthy volunteers before and after sleep restriction. The genetic analysis identified two variants near TRIB1 gene th…
Multiwavelength observations of the Be/X-ray binary 4U1145-619
1997
We report optical and infrared observations of the massive X-ray binary system 4U1145-619 (V801 Cen) which show that the circumstellar disc of the Be star component is in decline. Infrared J,H,K,L magnitudes of V801Cen have been monitored from 1993 March to 1996 April. H alpha spectra have been obtained throughout the same period. We find that both the infrared excess and the Balmer emission have been in decline throughout the period of observations. A 13 year optical and X-ray history of the source has been collated, revealing a possible correlation between the optical and X-ray activity. In addition, we have used u,v,b,y,beta indices, corrected for both circumstellar and interstellar effe…
Tertiary Chiral Nanostructures from C‐H∙∙∙F Directed Assembly of Chiroptical Superatoms
2021
Chiral hierarchical structures are universal in nature, whereas quite challenging to mimic in man-made synthesis. We report herein the synthesis and structure of tertiary chiral nanostructures with 100% optical purity. A novel synthetic strategy, using chiral reducing agent, R and S -BINAPCuBH 4 (BINAP is 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl), is developed to access to atomically precise, intrinsically chiral [Au 7 Ag 6 Cu 2 ( R - or S -BINAP) 3 (SCH 2 Ph) 6 ]SbF 6 nanoclusters in one-pot synthesis. The clusters represent the first tri-metallic superatoms with inherent chirality and fair stability. Both metal distribution (primary) and ligand arrangement (secondary) of the enantiomer…
Market efficiency and the long-memory of supply and demand: is price impact variable and permanent or fixed and temporary?
2016
In this comment we discuss the problem of reconciling the linear efficiency of price returns with the long-memory of supply and demand. We present new evidence that shows that efficiency is maintained by a liquidity imbalance that co-moves with the imbalance of buyer vs. seller initiated transactions. For example, during a period where there is an excess of buyer initiated transactions, there is also more liquidity for buy orders than sell orders, so that buy orders generate smaller and less frequent price responses than sell orders. At the moment a buy order is placed the transaction sign imbalance tends to dominate, generating a price impact. However, the liquidity imbalance rapidly incre…
How is weight stigma related to children's health-related quality of life? A model comparison approach
2018
Purpose. Obesity is a highly stigmatizing condition for both adults and children, and both obesity and stigma experiences are negatively related with Health-Related Quality of Life (HRQoL). However, the relations among these constructs have been modeled in different and sometimes inconsistent terms in past research, and have been the object of surprisingly few studies in pediatric populations. The present study addresses this gap by comparing, in a sample of pre-adolescent children, four competing models (i.e., additive, mediation, moderation, and moderated-mediation models) accounting for the role of stigma experiences in the concurrent relation between body weight and HRQoL. Methods: A co…
Heritability and genome-wide association analyses of sleep duration in children: The EAGLE Consortium.
2016
STUDY OBJECTIVES: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.METHODS: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Cons…
Enantioselective Friedel-Crafts reaction of hydroxyarenes with nitroenynes to access chiral heterocycles via sequential catalysis
2021
Naphthols, hydroxyindoles and an activated phenol are reacted with differently substituted (E)-nitrobut-1-en-3-ynes using the commercially available Rawal's chiral squaramide. The corresponding β-nitroalkynes were obtained with good yields and excellent enantioselectivities. Moreover, dihydronaphthofurans can be accessed via silver catalysed cyclization in a tandem one-pot procedure, with high preservation of the optical purity.