Search results for "exchanger"
showing 10 items of 101 documents
Space charge accumulation in undersea HVDC cables as function of heat exchange conditions at the boundaries – water-air interface
2020
Transmission lines with undersea HVDC cables are an interesting technological solution for the supply of electrical energy to islands. The accumulation of space charge inside the dielectric layer of a HVDC cable is one of the most important element to consider in its design and during operation. The formation of space charge is due to various factors including the high dependence on the temperature of the electrical conductivity of the insulation and the establishment of a thermal gradient under load conditions. This research is focused on the space charge accumulation phenomenon around a section of a HVDC cable half dipped in water and half in air. Due to the high difference in thermal con…
Identification of loci of functional relevance to Barrett's esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative tra…
2019
Esophageal adenocarcinoma (EA) and its precancerous condition Barrett's esophagus (BE) are multifactorial diseases with rising prevalence rates in Western populations. A recent meta-analysis of genome-wide association studies (GWAS) data identified 14 BE/EA risk loci located in non-coding genomic regions. Knowledge about the impact of non-coding variation on disease pathology is incomplete and needs further investigation. The aim of the present study was (i) to identify candidate genes of functional relevance to BE/EA at known risk loci and (ii) to find novel risk loci among the suggestively associated variants through the integration of expression quantitative trait loci (eQTL) and genetic…
Ryanodine receptor- and sodium-calcium exchanger-mediated spontaneous calcium activity in immature oligodendrocytes in cultures
2019
Myelination in the central nervous system depends on interactions between axons and oligodendrocyte precursor cells (OPCs). Action potentials in an axon can be followed by release of biologically active substances, like glutamate, which can instruct OPCs to start myelination. Myelin Basic Protein (MBP) is an "executive molecule of myelin" required for the formation of compact myelin. As cells of the oligodendrocyte lineage (OLCs) are capable of producing MBP in pure oligodendrocyte cultures, i.e. without neurons, we investigated Ca2+ signaling in developing OLCs in cultures. We show that spontaneous Ca2+ transients (CTs) occur at very low frequency in both bipolar OPCs and mature oligodendr…
Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes
2019
Visual Abstract
Thermal response test analysis for U-pipe vertical borehole heat exchangers under groundwater flow conditions
2021
[EN] Conventional models used in the analysis of thermal response test data only consider conduction as heat transfer mechanism. In cases where presence of groundwater is detected, convection heat transmission plays an important role, so its influence must be determined in the calculation of the effective thermal conductivity, usually overestimated in these situations, increasing its value the higher the power injected and the time elapsed. In this work, based on the data collected in a borehole located at UPV (Valencia) in which have been carried out three thermal response tests with different characteristics, has been implemented a variation of the finite line source model introducing an …
High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression
2013
Tryptase(+) mast cells (MCs), abundant in the invasive front of tumours, contribute to tissue remodelling. Indeed, protease-activated receptor- 2 (PAR-2) activation by MC-tryptase is considered an oncogenic event in colorectal cancer (CRC). Recently, we have suggested NHERF1 as a potential new marker in CRC. In this study, we aimed to determine the distribution of tryptase(+) MCs and PAR-2 and to examine the relationship between PAR-2 and NHERF1, investigating their reputed usefulness as tumour markers. We studied a cohort of 115 CRC specimens including primary cancer (C) and adjacent normal mucosa (NM) by immunohistochemical double staining, analyzing the protein expression of MC-tryptase,…
Cardioprotective Effects of the Na + /H + Exchange Inhibitor Cariporide in Patients With Acute Anterior Myocardial Infarction Undergoing Direct PTCA
2000
Background —Activation of Na + /H + exchange in myocardial ischemia and/or reperfusion leads to calcium overload and myocardial injury. Experimental studies have shown that Na + /H + exchange inhibitors can attenuate Ca 2+ influx into cardiomyocytes. We therefore performed a multicenter, randomized, placebo-controlled clinical trial to test the hypothesis that inhibition of Na + /H + exchange limits infarct size and improves myocardial function in patients with acute anterior myocardial infarction (MI) treated with direct PTCA. Methods and Results —One hundred patients were randomized to receive placebo (n=51) or a 40-mg intravenous bolus of the Na + /H + exchange inhibitor cariporide (HOE…
Energy-saving potential of ground source multiple chillers in simple and hybrid configurations for Mediterranean climates
2022
Air conditioning accounts for a large share of energy usage in residential and tertiary sectors. Renewable energy technologies offer promising solutions to reduce the environmental impacts of meeting buildings’ energy loads. The possibility of using the soil as a thermal reservoir for heating and cooling systems has gained growing attention in the last decade due to its high potential for energy saving. In this paper, the benefits achievable using ground source chillers for air conditioning in an office building located in Southern Italy are discussed. A multiple chillers system coupled with a borehole heat exchanger is investigated and compared to conventional air-cooled and water-cooled s…
THERMAL-HYDRAULIC STUDY IN SUPPORT OF THE DESIGN OF THE DEMO BALANCE OF PLANT
2020
The European Research Roadmap to the Realisation of Fusion Energy, foresees that the Demonstration Fusion Power Reactor (DEMO) is going to be the successor of ITER reactor in the pathway towards the exploitation of nuclear fusion to produce electric energy on an industrial scale. It will, hence, have to deliver hundreds MW of electric power ensuring an adequate availability and reliability of operation over a reasonable time span. EU-DEMO pre-conceptual design is being conducted by research institutions and universities from 26 countries of European Union, Switzerland and Ukraine, with the main aim to provide electric energy to the grid from nuclear fusion reactions by 2050. However, where …
Pre-conceptual design of EU-DEMO Divertor primary heat transfer systems
2021
Abstract In the frame of the activities promoted and encouraged by the EUROfusion Power Plant Physics and Technology (PPPT) department aimed at developing the EU-DEMO fusion reactor, strong emphasis has been recently addressed to the whole Balance of Plant (BoP) which represents the set of systems devoted to convert the plasma generated thermal power into electricity and to deliver it to the grid. Among these systems, the Divertor Primary Heat Transfer Systems (PHTSs) are intended to feed coolant to the two main components of the Divertor assembly, namely the Plasma Facing Components (PFCs) and the Cassette Body (CB). Since the DEMO Divertor must withstand high heat flux loads together with…