Search results for "exosomes"
showing 10 items of 209 documents
Effects of exosomes released by NSCLC cells on osteoclasts differentiation.
Effects of exosomes released by NSCLC cells on osteoclasts differentiation Pucci M., Taverna S., Corrado C., Giallombardo M., Rolfo C. and Alessandro R. Non-small cell lung cancer (NSCLC) has a poorly 5-year survival rate, as a consequence of the delay in the detection of the disease. The majority of patients are diagnosed in an advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing osteoclasts (OCs) and bone-forming osteoblasts (OBs) activity is lost in bone metastasis, inducing osteoclastogenesis. Most of the patients with lung cancer are treated with EGFR inhibitors (TKIs). Numerous st…
Crosstalk between chronic myelogenous leukemia (CML) and bone marrow stromal cells: role of interleukin 8 and CML derived- exosomes
2013
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by the t(9:22) (q34:q11) reciprocal translocation, resulting in the expression of the chimeric Bcr–Abl oncoprotein with constitutive tyrosine kinase activity. Exosomes (Exo) are small vesicles of endosomal origin and of 40-100 nm diameter released by many cell types including cancer cells. Several data indicate that Exo play an important role in cell-to-cell communication and tumor-stroma interaction, thus potentially affecting cancer progression. It is well known that stromal microenvironment contributes to disease progression through the establishment of a bi-directional crosstalk with cancer cells. In the b…
Metastatic colon cancer exosomes spread malignant properties in tumor microenvironment affecting the behavior of both tumor and endothelial cells
I tumori sono caratterizzati da eterogeneità intratumorale e questo rende difficile lo sviluppo di nuovi trattamenti. Diversi studi indicano gli esosomi come importanti componenti che agiscono sulla eterogeneità tumorale. In questo contesto, il nostro scopo è di capire se gli esosomi derivanti da cellule ad alto potenziale metastatico possono influenzare il comportamento delle cellule tumorali meno aggressive e le proprietà dell’endotelio, promuovendo la disseminazione delle cellule tumorali. La nostra strategia sperimentale è basata sull’uso di un modello isogenico. Abbiamo usato cellule di carcinoma del colon, SW620 e SW480, isolate rispettivamente dal tumore primario e dal sito di metast…
Crosstalk between chronic myelogenous leukemia (CML)and bone marrow stromal cells: role of exosomes in the IL8- dependent signalling mediated by EGFR…
2014
Introduction: CML is a myeloproliferative disorder characterized by Bcr-Abl oncoprotein with a constitutive tyr-kinase activity. Exosomes (exo) shed by cancer cells potentially affect tumor-stroma interaction through the establishment of a bi-directional crosstalk. Interleukin-8 (IL8) is a proinflammatory chemokine that regulate proliferation and survival of cancer cells. We previously demonstrated that CML-derived exo modulate bone marrow microenvironment through the IL8 secretion from stromal cells. EGFR, as well as IL8, regulate cell proliferation and survival; it has been recently demonstrated that EGFR ligands can signal via exosomes shed by cancer cells. We hypothesized that the effec…
Exosomes mediate a paracrine interplay between Chronic Myelogenous Leukemia and stromal cells: a role for interleukin 8
2013
Chronic myeloid leukaemia-derived exosomes promote tumour growth through an autocrine mechanism
2014
Focusing on a quantification and characterization of extracellular vesicles from blood in brain tumors
Molecular chaperones are required to maintain the proteome in a folded and functional state. Chaperones are structurally and functionally normal but participate in pathways that favor disease, as a tumorigenesis (1). The incidence of brain tumors is increasing rapidly and surgery is the first therapeutic intervention to safeguard the patient's life. The prognosis is poor even after surgical resection, followed by post-operatory chemo- and radio-therapy (2). Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. EVs play an essential role in both primary tumor growth and m…