Search results for "expression"
showing 10 items of 5168 documents
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
Functions of the translation factor eIF5A in cellular metabolism and transcriptional control
2023
El factor de inicio de traducción de eucariotas 5A (eIF5A) es una proteína esencial y conservada con funciones en las tres fases de la traducción. eIF5A está codificado por dos genes parálogos, TIF51A/TIF51B y EIF5A1/EIF5A2 en levadura y humanos respectivamente. eIF5A es la única proteína que contiene hipusina, una modificación esencial para su actividad, y se une a los ribosomas para facilitar la traducción de motivos con prolinas consecutivas o combinaciones de prolina con glicina y aminoácidos cargados. eIF5A participa en otras funciones y procesos como exporte de mRNAs nucleares, proliferación y apoptosis. Su asociación con enfermades como el cáncer es de interés. En esta tesis se han u…
Influence of Musical Context on the Perception of Emotional Expression of Music
2013
Factors determining and influencing the perception of emotional expression of music include those related to music itself, to the listener, and to the context. Among the latter there is also music, as we rarely listen to a single piece. A simple experimental study has been carried out into the effect of music listened to immediately beforehand on the perception of the emotional expression of a musical piece. The following variables were involved: type of emotional expression of music conceived in terms of a most basic sad-joyful dimension, initial and final mood of the listeners, their professional musical education vs. lack thereof, age, and gender. The subjects were students of three age …
A Comparative Analysis of Piotr Borkowski's (1963) and Roman Gajda's (1970) English–Polish Phraseological Dictionaries: Practice vs. Theory
2022
This paper offers an insight into the short and largely unexplored history of English–Polish and Polish–English phraseological lexicography. It aims to analyse two post-war English–Polish phraseological dictionaries, An English–Polish Dictionary of Idioms and Phrases (1963) by Piotr Borkowski and Wybór idiomów angielskich [A Selection of English Idioms] (1970) by Roman Gajda, from a qualitative and quantitative perspective. At first sight, they seem to share several features, insofar as both are monoscopal English–Polish volumes of a similar size; both were addressed to Polish learners of English; and both drew on The Kosciuszko Foundation Dictionary: English–Polish (1959), an exhaustive re…
25th Lexis and Grammar Conference
2008
Conclusion: Lessons Learnt With and Through Visual Narratives of Lived Multilingualism, and a Research Agenda
2019
Zur Sprache des deutschen Bürgerlichen Gesetzbuches : wie fest sind die Mehrwortverbindungen im BGB?
2015
On the language of the German Bürgerliches Gesetzbuch: How stable are the multiword expressions in the Civil Code? The aim of this paper is to characterize the language of the German Civil Code with a focus on multiword expressions, exploring how common these multiword expressions are in modern German and examining their replacement by other combinations. The analysis focuses on the relative stability of these expressions in the sense of Kjær (1992 and 1994)
Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice
2015
Duchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However…
ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.
2018
CXCL8 belongs to proinflammatory chemokines that are predominantly involved in neutrophil chemotaxis and degranulation. Several studies have suggested that secretion of CXCL8 from cancer cells have a profound effect on tumor microenvironment. In this study, in continuation to our previous work of understanding the global picture of invasion related genes in colorectal liver metastases, we clearly show an up-regulation of CXCL8 expression in the tumor cells at the invasion front as compared to the tumor cells in the inner parts of the tumor. Furthermore, ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete g…