Search results for "failure"

Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population

2015

Background: There are marked sex differences in cardiovascular disease (CVD) manifestation. It is largely unknown how the distribution of CVD risk factors or intermediate phenotypes explain sex-specific differences. Methods and Results: In 5000 individuals of the population-based Gutenberg Health Study, mean age 55 ± 11 years, 51% males, we examined sex-specific associations of classical CVD risk factors with intima-media thickness, ankle-brachial index, flow-mediated dilation, peripheral arterial tonometry, echocardiographic, and electrocardiographic variables. Intermediate cardiovascular phenotypes were related to prevalent CVD [coronary artery disease, heart failure, stroke, myocardial i…

Role of Biological Sex in the Cardiovascular-Gut Microbiome Axis

2022

There has been a recent, unprecedented interest in the role of gut microbiota in host health and disease. Technological advances have dramatically expanded our knowledge of the gut microbiome. Increasing evidence has indicated a strong link between gut microbiota and the development of cardiovascular diseases (CVD). In the present article, we discuss the contribution of gut microbiota in the development and progression of CVD. We further discuss how the gut microbiome may differ between the sexes and how it may be influenced by sex hormones. We put forward that regulation of microbial composition and function by sex might lead to sex-biased disease susceptibility, thereby offering a mechani…

Why do software development projects fail? : emphasising the supplier's perspective and the project start-up

2011

A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A.

2007

A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A. Am J Physiol Gastrointest Liver Physiol 292: G305-G314,2007; doi:10.1152/ajpgi.00100.2006.-Hepatic encephalopathy in patients with liver disease is associated with poor prognosis. This could be due to the induction by the transient episode of hepatic encephalopathy of long-lasting alterations making patients more susceptible. We show that a single transient episode of hyperammonemia induces long-lasting alterations in signal transduction. The content of the regulatory subunit of the protein kinase dependent on cAMP (PKA-RI) is increased in erythrocytes from cirrhotic patients. This increase is…

Submarine Slope Failures Along the Northern Sicilian Continental Margin (Southern Tyrrhenian Sea) and Possible Implications for Geo-Hazard

2013

Mass wasting and downslope movements are common processes that have contributed to shape the northern Sicilian continental margin (southern Tyrrhenian Sea) since the Late Quaternary. Nevertheless, processes controlling their evolution are still partially unknown and a variety of geologic factors can be responsible for their formation. In this work we present an overview of the main mass wasting features (submarine canyons, landslides, debris flows) observed and mapped in different sectors of the northern Sicilian margin. The margin is characterized by a narrow, steep continental shelf (1-2°) and a very irregular and steep (6-8°) upper slope. The main aims of this work are: (1) to outline th…

A fuzzy-set qualitative comparative analysis model to predict bank bailouts: a study of the Spanish financial system

2020

This paper examines the restructuring of the Spanish financial system. This study is justified by the massive economic and social impact of this process in Spain. Based on the annual accounts and the annual reports of Spanish credit institutions, a model was created to predict the possibility of bank failure or bailout. The variables were selected following a review of the literature. They included the legal form of the credit institution (savings bank versus bank), leverage, real estate investment, gross operating margin, staff costs and non-performing loans. Two variables that had not previously been used in studies of this type were also included in the model: risk-weighted assets and co…

STATE AID POLICY BETWEEN COMPETITION AND ECONOMIC GROWTH: THE IMPACT OF STATE AID TO R&D ON GDP IN THE EU MEMBER STATES

2012

The paper focuses on the analysis of the relationship between state aid to R&D and economic growth, measured by GDP level, providing empirical evidence of a correlation between these variables. Using a methodology which combines the regression technique and Granger causality, we found that GDP represents a significant causal determinant of state aid, while the correlation the variables considered is positive and statistically significant, suggesting that, in spite of disparities between Member States, government support through state aid to R&D has evolved from maintaining undistorted competition to the possibility to act as an incentive for the economic growth in the EU.

Endovascular Rescue Treatment for Occlusion of Renal Arteries Resulting in Acute Renal Failure

2018

Urgent revascularization of renal arteries for their occlusions resulting in acute renal failure still remains a therapeutic challenge. In this paper we describe 3 cases of successful endovascular interventions for acute non-iatrogenic occlusions of renal arteries. In the first patient we managed thrombotic occlusion of the renal artery that coexisted with gastrointestinal bleeding. We recanalized occluded renal artery using an extraction catheter and stenting, and managed the bleeding with the use of embolization coils. Endovascular repair resulted in normal dieresis, still several days after the intervention gastrointestinal hemorrhage recurred and patient died due to multiple organ failu…

Clinical Behavior of Ceramic, Hybrid and Composite Onlays. A Systematic Review and Meta-Analysis

2020

A systematic review and meta-analysis was performed to analyze the survival of onlay restorations in the posterior region, their clinical behavior according to the material used (ceramic reinforced with lithium disilicate, conventional feldspathic ceramic or reinforced with leucite; hybrid materials and composite), possible complications, and the factors influencing restoration success. The systematic review was based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement, without publication date or language restrictions. An electronic search was made in the PubMed, Scopus, Embase, and Cochrane databases. After discarding duplicate publications and stu…

Government policy failure in public support for research and development

2014

peer-reviewed Promoting Research and Development (R&D) and innovative activity is a key element of the EU Lisbon Agenda and is seen as playing a central part in stimulating economic development. In this paper we argue that, even allowing for benevolent policy-makers, informational asymmetries can lead to a misallocation of public support for R&D, hence government policy failure, with the potential to exacerbate preexisting market failures. Initially, we explore alternative allocation mechanisms for public support, which can help to minimize the scale of these government policy failures. Of these mechanisms (grants, tax credits, or allocation rules based on past performance), our results sug…