Search results for "far"
showing 10 items of 6421 documents
Centralizēti reģistrēto bioloģisko un biolīdzīgo medikamentu pieejamība Latvijā
2020
Bioloģisko medikamentu nozīme pieaug, tie ierindojas starp dārgākajām terapijām pasaulē, bet to ietekme uz sabiedrības veselību ir nenovērtējama, jo ļauj ārstēt vai atvieglot patoloģiskus stāvokļus, kuriem nesenā pagātnē terapija nav bijusi pieejama. Viena no galvenajām indikācijām bioloģisko zāļu lietošanai ir reimatoīdās slimības, kas pieder pie muskuļu un skeleta sistēmas (MSS) slimību grupas. MSS slimības ir viens no galvenajiem invaliditāti izraisošajiem faktoriem cilvēkiem darbspējīgā vecumā. Terapijai nepieciešamo zāļu pieejamība gan finansiālā, gan fiziskā ir nozīmīgs faktors, lai uzlabotu pacientu dzīves kvalitāti. Tāpat kā ģenērisko zāļu ienākšana tirgū paaugstina to finansiālo un…
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
2017
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence o…
SISTEMI D’INTERESSE FARMACEUTICO INTERAZIONE CON MODELLI DI BIOMEMBRANA MEDIANTE METODI CHIMICO-FISICI: TECNICHE CALORIMETRICHE E MONOLAYERS
2012
Bisfosfonati: utilità terapeutiche e reazioni avverse di interesse odontostomatologico
2020
I bifosfonati hanno la capacità di modulare il turnover osseo, controllare e ridurre il rimodellamento in corso di riassorbimento.Il loro meccanismo d’azione si basa sulla capacità di inibire il riassorbimento osseo mediato dagli osteoclasti.
Contributo per una visione contemporanea dell’azienda agricola: tra sostenibilità e sfide del mondo digitale
2023
Le sfide che l’umanità sta affrontando e da cui dipende la sopravvivenza del pianeta, il diffondersi nell’ambito dell’attività agricola di tecnologie digitali sempre più avanzate e la necessità di adottare un approccio sostenibile che preservi le risorse a tutela delle generazioni future hanno condotto l’azienda agricola a cambiare gradualmente volto. Questo libro mira a contribuire a un’aggiornata riflessione sul ruolo dell’imprenditore agricolo e dell’azienda da lui condotta, osservandone l’organizzazione e composizione alla luce delle regole che oggi la disciplinano e guardando alle innovazioni necessarie a garantire il raggiungimento dei pressanti obiettivi climatici e ambientali verso …
Eliminación de la actividad silanofílica en cromatografía líquida en fase inversa mediante el uso de aditivos
2013
La gran mayoría de los compuestos utilizados como principios activos en los productos farmacéuticos contienen átomos de nitrógeno básicos en su estructura. Su análisis por cromatografía líquida de fase inversa (reversed-phase liquid chromatography, RPLC) con columnas de sílice presenta una serie de inconvenientes, entre los que destacan retenciones elevadas, picos con colas y bajas eficacias, lo que se debe a la presencia de grupos silanoles residuales en la fase estacionaria que cuando están ionizados, interaccionan con los analitos catiónicos a través de un proceso de intercambio iónico, siendo el efecto más o menos pronunciado dependiendo de la columna seleccionada. Aunque aparentemente …
Recent Advances in Drug Delivery from the Oral Cavity. Focus on innovative buccal drug delivery devices
2011
In this report, the drug administration via the oral cavity is discussed. Regional variations in oral mucosae, drug delivery via the keratinised mucosae for local treatment, and drug delivery via the not keratinised mucosae for local and systemic treatments are analyzed, focusing on Buccal drug delivery devices. Finally the IntelliDrug Device is presented as a revolutionary delivery system.
Farmland abandonment in Europe: Identification of drivers and indicators, and development of a composite indicator of risk
2015
Accounting for more than half of the European Union's (EU) territory, agriculture ensures food production, manages important natural resources and supports socio-economic development of rural areas. Moreover, it is estimated that 50% of all plant and animal species (including some of that are listed in the EU Habitat Directive) depend on agricultural practices. The continuation of appropriate agricultural land management is essential to ensure these primary functions. Avoidance of farmland abandonment is therefore an important rationale for the EU's Common Agricultural Policy which requires improved knowledge of this phenomenon at the European level. This study assesses the risk of farmland…
Farming Efficiency and the Survival of Valuable Agro-Ecosystems: A Case Study of Rice Farming in European Mediterranean Wetlands
2009
Beyond the conventional role of providing food, rice farming in European Mediterranean wetlands performs a valuable non-marketable function related to the provision of environmental services. Rice and biodiversity are jointly produced, so that provision of flooded-rice-fields based environmental services depends crucially on private profitability of rice farming. Recent reforms of the Common Agricultural Policy (CAP) and increasing access of third party countries to the domestic European market are challenging the competitiveness of European rice growers. This paper combines conventional competitiveness indicators and non-parametric efficiency analysis to ascertain the economic profitabilit…
Economic assessment of Eucalyptus (spp.) for biomass production as alternative crop in Southern Italy
2015
The increase in energy prices and the stagnation of sales prices of the main agricultural commodities required a rethinking of farm production strategies. Since during the last years, thanks to a series of policies aimed at promoting renewable sources it has been a rapid diffusion of lignocellulosic biomass species, this paper aimed at evaluating the economic feasibility of the introduction of eucalyptus (Eucalyptus spp.) as energy crop for farmers of Southern Italy, by comparing it with traditional crop rotations. In particular, economic analysis has been carried out in a representative case study located in the Sicilian hilly hinterland where, in 2013, it has been built a biomass plant fo…