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showing 10 items of 6421 documents
Drug release from α,β-poly(N-2-hydroxyethyl)-DL-aspartamide based microparticles
2004
Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymer has been alpha,beta-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEAGMA copolymer (PHG) has been crosslinked in the presence of acrylic acid (AA) or methacrylic acid (MA) at various concentration. The obtained microparticles have been characterized by FT-IR spectrophotometry, particle size distribution analysis and scanning electron microscopy. In order to have information about water affinity of the prepared samples, swelling measurements have been carried out in aqueous media which simulate some biological f…
HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein–Protein Interaction and Targeting by Triazole-Based Compounds through In Silico…
2023
Protein–protein interactions (PPI) represent attractive targets for drug design. Thus, aiming at a deeper insight into the HSV-1 envelope glycoprotein D (gD), protein–protein docking and dynamic simulations of gD-HVEM and gD-Nectin-1 complexes were performed. The most stable complexes and the pivotal key residues useful for gD to anchor human receptors were identified and used as starting points for a structure-based virtual screening on a library of both synthetic and designed 1,2,3-triazole-based compounds. Their binding properties versus gD interface with HVEM and Nectin-1 along with their structure-activity relationships (SARs) were evaluated. Four [1,2,3]triazolo[4,5-b]pyridines were i…
COUPLING ELECTROCHEMISTRY TO ELECTROSPRAY: A NOVEL PREPARATION OF GOLD NANOSTRUCTURES
2013
nanoparticles on ITO (Indium tin oxide) coated glass using the electrospray (ESI) method Method:The starting point of this study is that the ESI/MS spectrum (Figure 1) of an ethanolic solution of HAuCl 4 shows a reduction process of Au (III) strongly dependent on the Cone Voltage (CV) values (20, 80, 150 V), affording to the ion at m/z 197 (Au+). Further, the decrease of the abundance of this ion at the highest cone voltage suggests the subsequent its reduction with the formation of Au 0 . Figure 1: ESI/MS spectra of an ethanolic solution of HAuCl4 at various cone voltages: Conclusion: Such experimental evidence leads us to use electrospray technique as a preparative tool to obtain the form…
Calidad de la preparación de quimioterapia asistida electrónicamente
2020
Los sistemas tecnológicos de soporte a la preparación manual de quimioterapia (QT) parenteral constituyen una de las principales herramientas para la prevención de errores de preparación (EP) en estos tratamientos. No obstante, la evidencia científica que respalda su beneficio potencial en la práctica asistencial es aún limitada. OBJETIVOS La Tesis Doctoral que se presenta se ha desarrollado con el fin de mejorar el conocimiento del valor añadido que aportan estos sistemas tecnológicos en la preparación de QT parenteral, en concreto, el Sistema ePASE® (IMF, SL), que integra un control de calidad cualitativo, mediante verificación del código data-matrix (DM) de las presentaciones, y cuantita…
Elevernas upplevelser och erfarenheter i skolanpassad handboll under gymnastiklektionerna
1997
The use of botanical raw materials in hair dyeing
2021
Rynek kosmetyczny bogaty jest w produkty umożliwiające zmianę koloru włosów. Dostępne są trzy możliwości koloryzacji chemicznej zależne od czasu utrzymywania się docelowego koloru. Wśród nich wyróżnia się farbowanie krótkotrwałe, półtrwałe oraz długotrwałe. Przy użyciu składników syntetycznych możliwe jest uzyskanie pełnego przekroju kolorystycznego. Doniesienia o niepożądanych skutkach ubocznych farb chemicznych, zarówno dotyczących skóry głowy jak i struktury włosów przemawiają za powrotem naturalnych sposobów koloryzacji włosów, i za rozwojem tego kierunku. Celem opracowania było przybliżenie możliwości zastosowania surowców roślinnych celem koloryzacji włosów. Scharakteryzowano następuj…
Making experts-by-experience : governmental ethnography of participatory initiatives in Finnish social welfare organisations
2018
This dissertation analyses expertise-by-experience in Finnish social welfare organisations as part of the participatory practices presented as new democracy. It employs a governmental ethnographic method to investigate how a person with difficult experiences is made into ‘an expert of one’s own life’ and how the subjectivity thus created is connected to different possibilities and rationales of participation. It asks: 1. What characterises the subjectivities created in the initiatives? 2. How (through which practices) are the participants constructed as experts? In this summary article the democratic quality of expert-making practices is interpreted through a critical democratic lens by inq…
Combining Social Service and Healthcare as the First Country in the World : Exploring the Impacts on Information Systems
2018
The Finnish government has decided to implement a reform in the social and healthcare system by combining the two in the future. There are several drivers for this change that have been identified. Large number of information systems that are not interoperable, challenges in data management and isolated service offering are the most significant ones. In the government’s strategy for the future the digitalisation will provide tools to solve these challenges. In this paper the landscape is outlined and the architecture choices are discussed. The enterprise architecture is applied for the largest county comprising of over 1900 social service and healthcare related information systems. The targ…
Exploring the Critical Success Factors in Social and Health Care Information Systems Project Procurement
2020
A welfare reform involving the mixing of social and health services is being introduced by the Finnish government. Several factors have been identified for this shift, the most relevant of which is that many information systems are not interoperable and data-related problems have been identified. Management and isolated offers of service. Digitalizing to solve these issues is part of the government’s policy. This paper outlines the change landscape and explores the architectural options of the proposed digitalisation process and crucial success factors. The Undertaking The design is applied to the largest county, which consists of over 1,900 information systems related to social support and…