Search results for "far"

SOLID LIPID NANOPARTICLES (SLNs) CONTAINING FERULIC ACID AGAINST OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES

2008

Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function

2020

Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of systemic blockade of ACVR2B ligands on cardiac function in experimental MI, and defined its efficacy to revert muscle wasting in ischemic heart failure (HF). Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) to study its effect on post-MI cardiac remodeling and on later HF. Cardiac function was determined with echocardiography, and myocardium analyzed with histological and biochemical methods for hypertrophy and fibrosis. Pharmacological blo…

Somatoforma veģetatīva disfunkcija farmaceita praksē

2020

Ar terminu “somatoforma veģetatīva disfunkcija” (SVD) tiek apzīmēti ķermeņa funkciju un sajūtu traucējumi, gadījumos, kad objektīvs un medicīniski izskaidrojams šo traucējumu iemesls netiek atrasts. Cilvēki ar SVD izjūt dažādus simptomus, piemēram, trauksmi, nemieru, paaugstinātu uzbudināmību, sāpes, kuņģa-zarnu trakta darbības traucējumus, sirds un asinsvadu sistēmas traucējumus, kas izraisa pastāvīgu uztraukumu un diskomfortu. Šie pacienti pārmērīgi meklē medicīnisko palīdzību un mierinājumu, bet viņiem ir grūti pieņemt ne patoloģiskus rezultātus medicīniskajā izmeklēšanā. SVD ir grūti diagnosticējama un prasa vairāku speciālistu palīdzību, ka arī paša cilvēka izturību un līdzestību. SVD …

Aislamiento y función de células progenitoras endoteliales de sangre periférica durante la evolución clínica de pacientes con infarto agudo de miocar…

2015

Las células endoteliales (CE) recubren el interior de los vasos sanguíneos constituyendo el endotelio, actualmente considerado un órgano muy activo e implicado en la regulación del tono vascular, el tráfico de células sanguíneas, el equilibrio hemostático, la permeabilidad, la proliferación, la supervivencia, y la respuesta inmunitaria tanto adaptativa como innata. Los factores de riesgo cardiovascular como la hipercolesterolemia, la diabetes y el tabaquismo pueden causar lesiones endoteliales, uno de los principales desencadenantes de la patogénesis en la aterosclerosis, predisponiendo al desarrollo y progresión de enfermedades cardiovasculares. Hoy en día, las enfermedades cardiovasculare…

Incarcerated women, welfare services and the process of re-entering society in Finland

2020

The pathways in and out of crime differ according to gender, people’s life histories, social situations and networks. Before being sentenced, many women have been living in vulnerable and traumatic life situations and violent relationships. Substance abuse often plays a crucial role in committing crimes. Being released from prison and re-entering society is a process that requires women’s own motivation to desist along with help and support from society. This chapter shows how women narrate and describe their experiences after being released from prison and especially how they report the ways in which the welfare system responds to their needs. They discussed their needs for support and ser…

Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…

2016

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…

Understanding McDonald's Among the "World’s Most Ethical Companies"

2008

The animal welfare policies and related public communication initiatives of McDonald’s corporation are examined in the context of the organization being named as one of the world’s most ethical organizations. The result is a framework for understanding how McDonald’s and similar organizations could warrant the status of a most ethical company. Specifically, the narrative strength of the company’s articulation of an animal welfare policy and its ongoing promotion as a legitimizing strategy illustrate how McDonald’s might address the social and ethical issues it encounters through its operations and how its stakeholding publics are likely to respond. By maintaining narrative strength in commu…

Financialization of Eldercare in a Nordic Welfare State

2022

Abstract The increasing presence of for-profit service providers in publicly-funded eldercare has transformed care in Nordic welfare states which have a strong tradition of public care provision. Macro-level research on care policies has mainly focused on public institutions, national policies, and marketization. The financialization of eldercare has not received much scholarly attention, and existing studies mostly focus on the UK. The financialization of eldercare refers to the ways in which care is both a site of profit extraction and financial engineering. The Nordic system is relatively universal, and, with rapidly ageing demographics, there is a secured demand for eldercare services. …

‘The will to not be empowered (according to your rules)’: Resistance in Finnish participatory social policy

2018

Participation has increasingly become a means and an end for successful and ‘empowering’ social policy. Building on previous governmentality critiques of participatory initiatives, this article investigates practices of resistance in the context of Finnish participatory social policy. I adopt a Foucauldian counter-conducts approach as my lens to study critical speech as a form of resistance in initiatives that invite marginalised people as ‘experts-by-experience’ in social welfare organisations. I illustrate how practices of governing and resistance are intertwined and mutually dependent in a much subtler and more practical manner than allows the often-used analytical dichotomy between domi…

The Human Right to Social Security and Its Impact on Socio-Political Action in Germany and Finland

2017

Social human rights have rarely been given attention in social work research or comparative studies on welfare states. The paper aims at filling the gap by analysing the conception of human beings inherent in human rights and in unemployment policy documents in Germany and Finland. Its focus lies on the right to social security, a central norm of the International Covenant on Economic, Social and Cultural Rights. The main question is what impact does the right to social security have on socio-political action in Germany and Finland. The results of the analysis, which was based on the objective hermeneutics, revealed a structural similarity between the conceptions of human beings in both cou…