Search results for "farmacologia"
showing 10 items of 411 documents
SY26-2ACETALDEHYDE ENDOCANNABINOIDS AND DOPAMINE: IS THIS –JUST- “A MENAGE A TROIS”?
2015
As ethanol, its first metabolite, acetaldehyde (ACD), enhances dopamine neurotransmission and exerts rewarding and motivational effects in animal models tailored for studying addictive-like behaviours. The endocannabinoid system fine-tuning dopamine cell activity, affects distinct drug-related behaviours and specific drug-induced effects. In light of this, it becomes urgent to investigate the implications of …
Effect of Acetaldehyde on CRF release form incubated hypothalamic explants
2008
In the past, Acetaldehyde (ACD), the main metabolite of ethanol (ETOH), was mainly studied for its toxic and adverse effects (1). However, recently, ACD was reported to determine behavioural and neurochemical effects, following ETOH assumption in rodents (2, 3). Indeed, ACD enhances dopamine levels in nucleus accumbens, stimulates beta-endorphin release from hypothalamic cells, mediating alcohol reinforcing effects (4). Since little is known about the effects of ACD on other central neuropeptides, in this research we aimed to investigate ACD influence on hypothalamic corticotropin-releasing factor (CRF) release. In order to ascertain this hypothesis, different doses of ACD (1, 10, 3x10 micr…
STATISTICAL ANALYSIS ABOUT DIFFUSION OF EXERCISE ADDICTION IN SICILY
2018
Exercise Addiction (EA) is a behavioral dysfunction marked by uncontrolled compulsion towards all kinds of physical activity. With the purpose of understanding the epidemiology of this steadily increasing phenomenon, we have done a statistical analysis about some data obtained through the administration of an online-questionnaire (Google forms): the same one was also converted into paper-questionnaire and then it has been administered in many gyms in Palermo and Trapani (Sicily-Italy). The sample examined consists of 976 people aged between 14 and 65 (47.3% of them are women and 52.7% are men). For 53.8% of analyzed people, physical activity is one of the most important things of their life…
Enzima convertidora frente a quimasa mastocitaria en la infiltración leucocitaria inducida por angiotensina-I : papel de fractalquina en la inflamaci…
2011
En la presente Tesis Doctoral se han abordado dos objetivos: el estudio de la contribución de la enzima convertidora (ECA) frente a la quimasa mastocitaria en la acumulación leucocitaria inducida por la síntesis endógena de Ang-II in vivo, y el estudio del papel de fractalquina (FRK) en la inflamación sistémica inducida por el extracto de humo de tabaco (EHT). La enzima convertidora de la angiotensina (ECA) es la principal enzima implicada en la formación de Ang-II a partir de Ang-I. Sin embargo, estudios realizados in vitro sugieren que la quimasa mastocitaria es más importante que la ECA en la síntesis de Ang-II en el sistema cardiovascular. Nosotros hemos demostrado que Ang-I induce inte…
Factores de riesgo cardiovascular y utilización de medicamentos en pacientes diabéticos tipo 2
2011
Objetivos: Describir los factores de riesgo cardiovascular (FRCV) en los pacientes diabéticos tipo 2 del departamento de salud de la Ribera, Comunidad Valenciana. Describir el uso de medicamentos utilizados para su tratamiento y analizar y evaluar la adecuación de este tratamiento a las recomendaciones de la Asociación Americana de Diabetes (ADA). Pacientes, método: Estudio observacional, descriptivo, transversal basado en la información recogida en las historias clínicas y mediante entrevista personal con los pacientes. Se seleccionó una muestra de 388 pacientes diabéticos tipo 2 y se recogieron datos relativos a sus FRCV, antecedentes de enfermedad cardiovascular (ECV), grado de control d…
Farmaci antimicrotubulari
2017
I microtubuli sono dei componenti del citoscheletro essenziali per lo svolgimento della normale divisione nucleare, in quanto formano il fuso mitotico, la struttura cellulare responsabile della corretta ripartizione dei cromosomi nelle cellule figlie.
Farmaci inibitori delle topoisomerasi
2020
Le DNA-topoisomerasi, identificate per la prima volta nel 1971, sono enzimi chiave nella regolazione della struttura topologica del DNA.
Futuro de los programas de mantenimiento con antagonistas en tratamiento de la dependencia de opiáceos.
2002
Introducción: El tratamiento con naltrexona, constituye una de las alternativas dentro de los programas de prevención de recaídas en la dependencia de opiáceos. Objetivo: Se revisan las características farmacológicas de la naltrexona y los aspectos clínicos de su administración en el tratamiento de dependientes de opiáceos, junto con los factores que pueden ayudar a mejorar la eficacia de los programas de mantenimiento con naltrexona. Resultados: La naltrexona, a dosis de 50 mg, bloquea los efectos farmacológicos y subjetivos de los opiáceos. Es habitualmente bien tolerada, provoca pocos efectos secundarios y por lo general leves, siendo las reacciones adversas graves infrecuentes. Problema…
Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice
2012
[EN] The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an anti-inflammatory agent in the treatment of ulcerative colitis (UC). Acute UC was induced in Balb/C mice by oral administration of 5% dextran sodium sulfate (DSS). The disease activity index was evaluated, and a histologic study was carried out. Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools. The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the…
Aging enhances contraction to thromboxane A2 in aorta from female senescence mice
2013
The time-course for aging-associated effects on vascular reactivity to U46619, a stable analogue of thromboxane A2 (TXA2), was studied in aorta from female senescence-accelerated mice-prone (SAMP8), a murine model of accelerated senescence. SAMP8 and senescence-accelerated mice-resistant (SAMR1) were divided into three groups: 3-, 6- and 10-month-old. Contractile curves to U46619 (10−9 to 10−6 M) were performed in aortic rings in the absence or in the presence of nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME; 10−4 M) and/or cyclooxygenase (COX) inhibitor indomethacin (10−5 M). Protein and gene expression for COX-1 and COX-2 were determined by immunofluoresce…