Search results for "fen"
showing 10 items of 3710 documents
Biogenic Fenton process - A possible mechanism for the mineralization of organic carbon in fresh waters.
2020
To explore the mechanisms that mineralize poorly bioavailable natural organic carbon (OC), we measured the mineralization of OC in two lake waters over long-term experiments (up to 623 days) at different pH and iron (Fe) levels. Both the microbial and photochemical mineralization of OC was higher at pH acidified to 4 than at the ambient pH 5 or an elevated pH 6. During 244 days, microbes mineralized up to 60% of OC in the 10-mu m filtrates of lake water and more than 27% in the 1-mu m filtrates indicating that large-sized microbes/grazers enhance the mineralization of OC. A reactivity continuum model indicated that the acidification stimulated the microbial mineralization of OC especially i…
The effect of temperature on cercariae production of two Rhipidocotyle trematodes parasitizing freshwater mussel, Anodonta anatina.
2013
Two bucephalid trematodes, Rhipidocotyle campanula and R. fennica are known to infect the duck mussel, Anodonta anatina. The infection will lead to decrease growth, reproduction and survival of A. anatina. Given the important role of temperature on cercariae production, a vital component of the parasite’s transmission and life cycle success, the effect of temperature on cercariae production of two Rhipidocotyle sp. in their molluscan host, Anodonta anatina, was investigated. Mussels were collected from the Rivers, Haajaistenjoki and Kuusaankoski, marked and allocated to three temperature treatments—high, intermediate and low. Between May 31-October 28, 2011, clams were individually monitore…
Evaluation of the efficacy of a new insecticide paint against malaria vectors
2015
La malaria continúa siendo un problema de salud pública global. Se calcula que en el mundo hay 3.300 millones de personas en 97 países y territorios que corren el riesgo de padecer el paludismo, y que para 1.200 millones ese riesgo es elevado (WHO, 2014). El control de la malaria a gran escala está altamente basado en al control del vector, principalmente mediante el uso de mosquiteras tratadas con insecticidas de larga duración (LLINs), y en menor medida, el Rociamiento Residual Intradomiciliario. Todos los tratamientos recomendados de LLINs y la mayoría del Rociamiento Residual Intradomiciliario se basan en el uso de piretroides. La creciente resistencia de los vectores de malaria a los p…
A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.
2015
Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …
Luokanopettajien kokemuksia lapsen surun kohtaamisesta koulussa
2018
Tutkimuksen tavoitteena on kuvata luokanopettajien kokemuksia lapsen surusta koulussa ja sitä, kuinka he ovat surun käsittelyn kokeneet. Tavoitteena on saada kuva luokanopettajien valmiuksista kohdata sureva lapsi ja siitä, tarvitsevatko he tukea tai koulutusta surun kohtaamiseen. Tutkimusasetelma on kvalitatiivinen ja se perustuu fenomenologiaan. Tutkimuksen aineistona on kolme luokanopettajan kirjoitelmaa ja yksi luokanopettajan haastattelu. Aineiston analysointiin on käytetty fenomenologista merkitysanalyysia. Luokanopettajien kokemusten mukaan lapsi tulee kouluun pian menetyksensä jälkeen, jolloin on tarpeen pohtia, kuinka surusta kerrotaan muulle luokalle. Luokanopettajien kokemuksissa…
Esteettinen metsä : näkökulmia ympäristöherkkyyteen ja sen merkitykseen metsäsuhteelle
2017
Tämän pro gradu- tutkielman tarkoituksena on selvittää mitä ympäristöherkkyys esteettisen ympäristökasvatuksen kontekstissa tarkoittaa ja mitä hyötyä siitä voi olla ihmisen metsäsuhteen rakentamiselle ja lujittamiselle. Tutkielman lähtökohtana on ollut huoli siitä, että yhä useamman suomalaisen luontosuhde tuntuu heikkenevän koko ajan, minkä seurauksena sekä ihmisten että luonnon hyvinvointi heikkenee. Suomessa metsä on yleisin ja helpoimmin saavutettava luontotyyppi, joten muodostamme luontosuhteemme useimmin juuri metsään. Ympäristökasvatuksessa on perinteisesti painotettu luonnontieteellisen tiedon merkitystä, mutta sen on useissa tutkimuksissa havaittu olevan riittämätön keino ympäristö…
Donald Winnicott luovuudesta
2019
Psykoanalyytikko Donald Winnicott ajattelee luovuutta koko elämää läpäisevänä olemisen tapana. Lastenlääkärinäkin työskennelleen Winnicottin mukaan luovuuden perusta on vauvan kyvyssä luoda oma maailmansa. Aikuisen ihmisen luovuus on tämän kyvyn säilyttämistä, kehittämistä ja kultivoimista läpi elämän. peerReviewed
Differential influence of vemurafenib and dabrafenib on patient lymphocytes despite similar clinical efficacy in melanoma
2014
Background: Since the majority of melanomas eventually become resistant and progress, combining selective BRAF inhibitors (BRAFi) with immunotherapies has been proposed to achieve more durable treatment responses. Here, we explored the impact of selective BRAFi on the hosts’ immune system. Patients and methods: Clinical data, whole blood counts (WBC) and serum lactate dehydrogenase (LDH) of 277 vemurafenib- and 65 dabrafenib-treated melanoma patients were evaluated. The frequency and phenotype of lymphocyte subpopulations were determined by flow cytometry while T cell cytokine secretion was measured by multiplex assays. Results: Progression-free survival (PFS) as well as overall survival (O…
Host filtering, not competitive exclusion, may be the main driver of arbuscular mycorrhizal fungal community assembly under high phosphorus
2023
A major goal in ecology is understanding the factors which determine the diversity and distribution of organisms. The outcome of the symbiotic relationship between plants and arbuscular mycorrhizal (AM) fungi is strongly influenced by soil phosphorus (P) availability. Despite this knowledge, there is still much to uncover about how soil P status can shape the taxonomic and phylogenetic assembly of root-colonising AM fungi. Additionally, there is a paucity of understanding about the implications of these changes for the outcome of the AM symbiosis in terms of plant growth, nutrient status and defence traits. We conducted a factorial pot experiment where sorghum (Sorghum bicolor) was grown un…
Utility of neutrophil-to-lymphocyte ratio to identify long-term survivors among HCC patients treated with sorafenib
2020
Sorafenib is the first multikinase inhibitor demonstrating a survival benefit for patients suffering from advanced hepatocellular carcinoma (HCC). However, 1 issue remains open: what is the factor able to predict which patients will be long survivors?In the present study, we harnessed the potential of conditional survival, aiming at estimating the probability that a patient receiving sorafenib survives for more than 3 years.The present multicentric study was conducted on a cohort of 438 HCC patients. The primary end point was conditional overall survival. Kaplan-Meier survival analysis was used to calculate conditional overall survival probabilities at 3 years.The 3-year conditional surviva…