Search results for "fetus"
showing 10 items of 293 documents
Gestational exposure to cocaine alters cocaine reward
2006
Exposure of the developing foetus to drugs of abuse during pregnancy may lead to persistent abnormalities of brain systems involved in drug addiction. Mice prenatally exposed to cocaine (25 mg/kg), physiological saline or non-treated during the last 7 days of pregnancy were evaluated in adulthood for the rewarding properties of cocaine (3, 25 and 50 mg/kg), using the conditioned place preference procedure. Dams treated with physiological saline gained significantly less weight over the course of gestation than controls; no other differences were observed in the maternal and offspring data. All the animals developed preference to 3 and 25 mg/kg of cocaine, but those treated prenatally with c…
The influence of gestational diabetes mellitus (GDM) and gestational hypertension (GH) on placental morphological changes
2020
Gestational diabetes mellitus (GDM) and gestational hypertension (GH) are some of the most common medical conditions associated with pregnancy. These can be correlated with placental morphopathological changes and implicitly can influence good fetal development. The age and weight of the mother can be correlated directly proportionally with those of the fetus but also with histoarchitecture and placental vascularization. The placental appearance associated with GDM and GH reveals macroscopic features, such as calcifications, fibrin deposits and placental infarcts, but the most relevant pathological features are the microscopic ones, highlighted by the classical staining techniques: Hematoxy…
L-citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia
2021
AbstractPreeclampsia, characterized by hypertension, proteinuria, and fetal growth restriction, is one of the leading causes of maternal and perinatal mortality. By far, there is no effective pharmacological therapy for preeclampsia. The present study was conducted to investigate the effects of L-citrulline supplementation in Dahl salt-sensitive rat, a model of superimposed preeclampsia. Parental DSSR were treated with L-citrulline (2.5 g/L in drinking water) from the day of mating to the end of lactation period. Blood pressure of the rats was monitored throughout pregnancy and markers of preeclampsia were assessed. Endothelial function of the pregnant DSSR was assessed by wire myograph. L-…
Posters Early pregnancy P01First trimester normograms for a wide variety of ultrasound, hemodynamic and serum parameters
2000
Background The aim of the study was to assess prospectively the evolution of multiple clinical parameters throughout the first trimester of pregnancy. Method A transvaginal ultrasound examination and a blood test was weekly performed until the 13th gestational week in a group of healthy volunteers. A total of 25 spontaneously conceived singleton pregnant women with good pregnancy outcome finally completed the study. The evolution of 10 transvaginal ultrasound parameters, 5 Doppler measurements and 6 serum parameters was studied. Results An increasing trend with advancing gestation was evident for the mean gestational sac (MSD) and amniotic sac (AS) diameters, trophoblastic rim, CRL and seru…
Prenatally detected double trisomy: Klinefelter and Down syndrome
2006
Double trisomies are a rare occurrence. We report the first case of a Down and Klinefelter's syndrome (48,XXY,+21) in a fetus that was prenatally diagnosed during the 15th week of pregnancy. Even though the nasal bone was present, and the color-Doppler study of the ductus venosus and the nuchal thickness were normal, the maternal serum test results indicated an increased risk of Down syndrome and consequentially a genetic amniocentesis was performed. A 48,XXY,+21 karyotype was observed and the patient decided to terminate the pregnancy. In this case, we did not find the typical ultrasound (US) signs that would have led us to the chromosomopathy; furthermore, we emphasize the advantages of u…
Hypothyroidism and pregnancy. Situation in Latvia
2015
The thyroid gland is the first of the body's endocrine glands to develop, on approximately the 24 th day or 3-4 weeks of gestation, but at around 10-12 weeks the thyroid begins to function on its own. Thyroid hormones are involved in regulation of vital body function. In general normal development, growth and reproduction cannot occur without them. The normal function of thyroid gland is predictor to normal pregnancy outcome and foetus development. It is important to know how many women have hypothyroidism and what kind of treatment they receive. Author selected and made retrospective analysis of women with hypothyroidism maternity cases from 2010 to 2011 year. Data compared to the control …
Der Säure-Basenstatus und die CO2-Transportfunktion des mütterlichen und fetalen Blutes zum Zeitpunkt der Geburt
1965
Als Voraussetzung fur die Analyse des Gasaustausches in der menschlichen Placenta werden die charakteristischen Daten fur den CO2-Transport und den Saure-Basenstatus im mutterlichen und fetalen Blut zum Zeitpunkt der Geburt bestimmt. Dabei ergeben sich als Mittelwerte bei 54 Fallen normaler Spontangeburt mit einzeitiger Entwicklung des Kindes, bei denen samtliche Meswerte vorliegen:
Can antepartum computerized cardiotocography predict the evolution of intrapartum acid-base status in normal fetuses?
2004
Background. To study the relationship between antepartum computerized cardiotocography (cCTG) and the evolution of intrapartum fetal acid-base balance in a low-risk population. Methods. Forty-nine healthy fetuses were prospectively followed up by antepartum cCTG (Oxford System 8002), fetal scalp blood sampling at the onset of the active phase of dilatation (3 cm) and at the beginning of the second stage of labor (10 cm) and study of acid-base status at birth in the umbilical cord. Correlation studies and linear regression analysis were performed. Results. Normal prelabor cCTG was followed by normal fetal acid-base balance in the different study periods. No relationship was found between cCT…
DIAGNOSI PRECOCE DELLA VENTRICOLOMEGALIA NEL I° TRIMESTRE:CASO CLINICO
2013
THE HYDROCEPHALUS IS ONE OF THE MOST FREQUENT CONGENITAL ANOMALIES
Clinical and molecular data in cases of prenatal localized overgrowth disorder: major implication of genetic variants in PI3K‐AKT‐mTOR signaling path…
2021
To describe clinical and molecular findings in a French multicenter cohort of fetuses with prenatal diagnosis of congenital abnormality and suspicion of a localized overgrowth disorder (LOD) suggestive of genetic variants in the PI3K-AKT-mTOR signaling pathway.We analyzed retrospectively data obtained between 1 January 2013 and 1 May 2020 from fetuses with brain and/or limb overgrowth referred for molecular diagnosis of PI3K-AKT-mTOR pathway genes by next-generation sequencing (NGS) using pathological tissue obtained by fetal autopsy. We also assessed the diagnostic yield of amniotic fluid.During the study period, 21 subjects with LOD suspected of being secondary to a genetic variant of the…