Search results for "fibra"
showing 10 items of 172 documents
Cholesterol-Like Effects of Selective Cyclooxygenase Inhibitors and Fibrates on Cellular Membranes and Amyloid-β Production
2007
Strong evidence suggests a mechanistic link between cholesterol metabolism and the formation of amyloid-beta peptides, the principal constituents of senile plaques found in the brains of patients with Alzheimer's disease. Here, we show that several fibrates and diaryl heterocycle cyclooxygenase inhibitors, among them the commonly used drugs fenofibrate and celecoxib, exhibit effects similar to those of cholesterol on cellular membranes and amyloid precursor protein (APP) processing. These drugs have the same effects on membrane rigidity as cholesterol, monitored here by an increase in fluorescence anisotropy. The effect of the drugs on cellular membranes was also reflected in the inhibitory…
Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes
2004
Abstract Background In rats, two peroxisomal 3-ketoacyl-CoA thiolase genes (A and B) have been cloned, whereas only one thiolase gene is found in humans. The aim of this study was thus to clone the different mouse thiolase genes in order to study both their tissue expression and their associated enzymatic activity. Results In this study, we cloned and characterized two mouse peroxisomal 3-ketoacyl-CoA thiolase genes (termed thiolase A and B). Both thiolase A and B genes contain 12 exons and 11 introns. Using RNA extracted from mouse liver, we cloned the two corresponding cDNAs. Thiolase A and B cDNAs possess an open reading frame of 1272 nucleotides encoding a protein of 424 amino acids. In…
Correlation of Pharmacological Properties of a Group of Hypolipaemic Drugs by Molecular Topology
1996
Abstract This investigation was undertaken to test the ability of the molecular connectivity model to predict the percentage of plasma protein binding, the percentage of total cholesterol reduction and oral LD50 in rats of a group of hypolipaemic drugs using multi-variable regression equations with multiple correlation coefficients, standard error of estimate, degrees of freedom, F-Snedecor function values, Mallow's CP and Student's t-test as criteria of fit. Regression analyses showed that the molecular connectivity model predicts these properties. Corresponding stability (cross validation) studies were made on the selected prediction models which confirmed their goodness of fit. The resul…
Estudio del armazón arquitectónico y del sistema vascular de los tumores neuroblásticos
2015
Los pacientes con tumores neuroblásticos presentan una evolución clínica heterogénea, desde la regresión espontánea hasta una alta propensión para la diseminación metastática generalizada. Aunque la aplicación de una clasificación de riesgo pre-tratamiento bien definida tiene un papel central en la mejora de la supervivencia durante los últimos años, han de llevarse a cabo más avances para mejorar la superviencia de los pacientes en general y específicamente el subgrupo de pacientes de alto riesgo. El estudio morfológico del tejido tumoral está contribuyendo a dicha mejora. La categoría histológica o el porcentaje de estroma tumoral, así como el grado de diferenciación de las células neurob…
On the geometric structure of the class of planar quadratic differential systems
2002
In this work we are interested in the global theory of planar quadratic differential systems and more precisely in the geometry of this whole class. We want to clarify some results and methods such as the isocline method or the role of rotation parameters. To this end, we recall how to associate a pencil of isoclines to each quadratic differential equation. We discuss the parameterization of the space of regular pencils of isoclines by the space of its multiple base points and the equivariant action of the affine group on the fibration of the space of regular quadratic differential equations over the space of regular pencils of isoclines. This fibration is principal, with a projective group…
Affine Surfaces With a Huge Group of Automorphisms
2013
We describe a family of rational affine surfaces S with huge groups of automorphisms in the following sense: the normal subgroup Aut(S)alg of Aut(S) generated by all algebraic subgroups of Aut(S) is not generated by any countable family of such subgroups, and the quotient Aut(S)/Aut(S)alg cointains a free group over an uncountable set of generators.
On Fibrations Between Internal Groupoids and Their Normalizations
2018
We characterize fibrations and $$*$$ -fibrations in the 2-category of internal groupoids in terms of the comparison functor from certain pullbacks to the corresponding strong homotopy pullbacks. As an application, we deduce the internal version of the Brown exact sequence for $$*$$ -fibrations from the internal version of the Gabriel–Zisman exact sequence. We also analyse fibrations and $$*$$ -fibrations in the category of arrows and study when the normalization functor preserves and reflects them. This analysis allows us to give a characterization of protomodular categories using strong homotopy kernels and a generalization of the Snake Lemma.
Tissue-specific Expression of Two Peroxisomal 3-ketoacyl-CoA Thiolase Genes in Wild and PPARα-null Mice and Induction by Fenofibrate
2003
Our laboratory cloned two peroxisomal 3-ketoacyl-CoA thiolase genes in mouse. These genes were named mThA (mouse peroxisomal Thiolase A) and mThB (mouse peroxisomal Thiolase B) by comparison with peroxisomal thiolase genes known in rat (Hijikata et al. 1990, Bodnar & Rachubinski, 1990). In this study, we analysed the tissue expression of the two thiolase genes on wild and on PPARa-null mice.
Oligonucleotide-Hybridization Fiber-Optic Biosensor using a Narrow Bandwidth Long Period Grating
2017
Nanometric narrowband Long Period Gratings (LPG) are investigated for the implementation of improved fiber optic biosensors. The reduction of more than one order of magnitude in the linewidth of the LPG with respect standard LPG at 1500 nm, leads to the improvement of the resolution of the sensor. By selecting the proper fabrication parameters (high numerical aperture, relatively high order mode and large length), LPGs with a 3-dB bandwidth of 1.5 nm were fabricated. The sensitivity of the LPG as a refractometer was calculated, and experimentally characterized in detail. In particular, the LP0,17 and LP0,18 resonances were investigated, in order to select the most suitable one for the bioex…
An approach to the measurement of the nonlinear refractive index of very short lengths of optical fibers
2018
A method for the measurement of the nonlinear-refractive index coefficient in single-mode optical fibers is presented. It takes advantage of the high sensitivity of the acousto-optic interaction effect in optical fibers to the fiber properties. Direct measurement of the nonlinear-refractive index change resulting from cross-phase modulation between a probe and a pump signal is obtained from the fiber's acousto-optic interaction performance. It is a non-interferometric method in which a very short length of fiber (<0.25 m) is required.