Search results for "fibra"
showing 10 items of 172 documents
The Topology of the Milnor Fibration
2020
The fibration theorem for analytic maps near a critical point published by John Milnor in 1968 is a cornerstone in singularity theory. It has opened several research fields and given rise to a vast literature. We review in this work some of the foundational results about this subject, and give proofs of several basic “folklore theorems” which either are not in the literature, or are difficult to find. Examples of these are that if two holomorphic map-germs are isomorphic, then their Milnor fibrations are equivalent, or that the Milnor number of a complex isolated hypersurface or complete intersection singularity \((X, \underline {0})\) does not depend on the choice of functions that define …
Analog Photonic Fractional Signal Processing
2018
Fil: Cuadrado Laborde, Christian. Universidad de Valencia. Instituto Universitario de Ciencia de los Materiales; España Fil: Cuadrado Laborde, Christian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cuadrado Laborde, Christian. Pontificia Universidad Católica Argentina. Facultad de Química e Ingeniería del Rosario; Argentina Fil: Poveda-Wong, Luis. Universidad de Valencia. Instituto Universitario de Ciencia de los Materiales; España Fil: Carrascosa, Antonio. Universidad de Valencia. Instituto Universitario de Ciencia de los Materiales ; España Fil: Diez, Antonio. Universidad de Valencia. Instituto Universitario de Ciencia de los Materiales; España Fil: Cruz, Jo…
Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA sequence and new insight in expression.
2001
X-linked adrenoleukodystrophy (X-ALD) is an inherited demyelinating disorder due to mutations in the ALD gene, which encodes a peroxisomal ABC half-transporter (ALDP). It has been suggested that ALDP assembles with ALDRP (adrenoleukodystrophy-related protein), a close homologous half-transporter, to form a functional heterodimer. For the first time full-length ALDRP cDNA (5.5 kb) was cloned, and 5' and 3' RACE analysis revealed that alternative usage of polyadenylation sites generates the two transcripts of 3.0 and 5.5 kb observed in the rat in Northern blot analysis. Southern blotting and chromosomal mapping demonstrated one ALDR locus in the rat genome. Characterisation of the 3' flanking…
Homotopy limits for 2-categories
2008
AbstractWe study homotopy limits for 2-categories using the theory of Quillen model categories. In order to do so, we establish the existence of projective and injective model structures on diagram 2-categories. Using these results, we describe the homotopical behaviour not only of conical limits but also of weighted limits. Finally, pseudo-limits are related to homotopy limits.
Lipid-lowering drug use in Italian primary care: effects of reimbursement criteria revision
2008
OBJECTIVE: To assess whether the prescribing pattern of lipid-lowering drugs (LLD) changed after reimbursement criteria revision in a general practice in southern Italy. METHODS: From the Caserta-1 Local Health Service database, 93 general practitioners (GPs) who had consistently sent data about their patients during the years 2003-2005 were recruited. Prevalence of use and incidence of new treatments were calculated for each year, stratified by three drug cohorts: statins, omega-3 fatty acids, and fibrates. Subanalyses by gender, age, and indication of use were performed. RESULTS: Overall, 1-year prevalence of LLD use increased from 2003 to 2004. After reimbursement criteria revision (Nove…
Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug.
2007
An increasing number of newly developed drugs show bioavailability problems due to poor water solubility. Formulating the drugs as nanosuspensions may help to overcome these problems by increasing saturation solubility and dissolution velocity. In the present study the bioavailability of the poorly soluble fenofibrate following oral administration was investigated in rats. Four formulations were tested: a nanosuspension type DissoCube(R), one solid lipid nanoparticle (SLN) preparation and two suspensions of micronized fenofibrate as reference formulations, one suspension in sirupus simplex and a second in a solution of hydroxyethy-cellulose in physiological saline. Both colloidal drug deliv…
Hypolipidaemic effects of fenofibrate are not altered by mildronate-mediated normalization of carnitine concentration in rat liver.
1999
The five-fold higher carnitine content in the liver of fenofibrate-treated rats addresses the question about the possible role of this enhancement in the hypolipidaemic effect of the drug and the underlying mechanisms. When fenofibrate was administered with mildronate (a gamma-butyrobetaine hydroxylase inhibitor) in suitable amount, the content in carnitine was found to be normalized in liver. However, triglyceride contents of liver and serum were then at least as low as in rats treated by fenofibrate only. When carnitine concentration was lowered by mildronate to the third of the normal value, a marked increase in triglycerides occurred both in liver and serum, while the five-fold increase…
Analyses of Dual Polarization WDM and SCM Radio over Fiber and Radio over FSO for C-RAN Architecture
2016
En este trabajo se simulan y verifican experimentalmente los esquemas de transmisión para una Arquitectura de Red de Acceso Radio Centralizada (C-RAN) basados en la combinación de dos tecnologías: Radio sobre Fibra (RoF) y Radio sobre FSO (RoFSO). Las configuraciones propuestas se optimizan para la evolución a largo plazo (LTE) con un ancho de banda de 20 MHz utilizando una modulación de amplitud en cuadratura de 64-QAM en términos de magnitud de vector de error (EVM). En primer lugar, se comparan las mediciones de la multiplexación por división de polarización mediante la combinación de RoF y RoFSO (PDM-RoF/FSO) con los modelos de simulación. Esto se amplía con la combinación de PDM-Multip…
Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production
2004
Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective NSAID. Many COX-2-selective NSAIDs tested raised Abeta42, including multiple COX-2-selective derivatives of two Abeta42-lowering NSAIDs. Compounds devoid of COX activity and the endogenous isoprenoids FPP and GGPP also raised Abeta42. These compounds seem to target the gamma-secretase complex, increasing gamma-secretase-catalyzed production of Abeta42 in vitro. Short-term in vivo studies show that two Abeta42-raising comp…
Isolation and characterization of a cDNA encoding rat liver cytosolic epoxide hydrolase and its functional expression in Escherichia coli.
1993
A cDNA of 1992 base pairs encoding the complete rat liver cytosolic epoxide hydrolase has been isolated using a polymerase chain reaction-derived DNA fragment (Arand, M., Knehr, M., Thomas, H., Zeller, H. D., and Oesch, F. (1991) FEBS Lett. 294, 19-22) known to represent the 3'-end of the cytosolic epoxide hydrolase mRNA. Sequence analysis revealed an open reading frame of 1662 nucleotides corresponding to 554 amino acids (M(r) = 62,268). The DNA sequence obtained did not display significant homology to the sequences of microsomal epoxide hydrolase or leukotriene A4 hydrolase or to any other DNA included in the EMBL Data Bank (release 32). On Northern blotting of rat liver RNA, a single mRN…