Search results for "fibroblasto"
showing 5 items of 5 documents
Nuevas perspectivas en el abordaje terapéutico de la psoriasis
2014
En la actualidad las enfermedades inflamatorias crónicas de la piel, como la psoriasis, tienen un impacto significativo en cuanto a la calidad de vida de los pacientes y sus familias, además de representar una carga económica considerable. Se estima que aproximadamente el 3% de la población mundial sufre psoriasis. Esta patología presenta tres componentes característicos: un desequilibrio entre la respuesta inmune local y sus mecanismos reguladores, una respuesta inflamatoria exagerada y una renovación epidérmica incrementada. A pesar del efecto beneficioso que ha supuesto la introducción de las nuevas aunque costosas terapias biológicas en el tratamiento sistémico de la psoriasis, el metot…
Estudio de la transformación fibroblasto-miofibroblasto, la senescencia y el metabolismo de fibroblastos aislados de pacientes con fibrosis pulmonar …
2021
La Fibrosis Pulmonar idiopática (FPI) está definida como una neumonía intersticial fibrosante crónica de causa desconocida, progresiva y fatal que afecta fundamentalmente a adultos mayores de 60 años, limitada a los pulmones y asociada con el patrón histopatológico de neumonía intersticial usual (NIU). La ausencia de manifestaciones específicas de la FPI supone un obstáculo para su detección temprana. Es una enfermedad de diagnóstico difícil y tardío, con un abordaje terapéutico de eficacia reducida. Estas características suscitan la necesidad de encontrar nuevos biomarcadores asociados a la fibrosis y nuevas dianas terapéuticas para un diagnóstico temprano e incrementar la calidad y espera…
Symmetrical palatal fibromatosis: An additional case report with immunohistochemical characterization
2021
Background The term "symmetrical palatal fibromatosis" was recently suggested to designate bilateral palatal lesions presenting as typically broad, "mirror" images on the posterior lateral region of the hard palate. Purpose We report an additional case of this as-yet poorly understood oral lesion in a 67-year-old male patient, with emphasis on differential diagnoses and immunohistochemical characterization. Case Report The histopathological examination demonstrated a hypocellular, fibrous connective tissue with prominent thick collagen bundles and few blood vessels. Scattered large, stellate, and sometimes binucleated fibroblasts were found. Immunohistochemistry was positive for vimentin an…
Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management
2013
Dermatofibrosarcoma protuberans (DFSP) is a rare superficial tumor characterized by high rates of local recurrence and low risk of metastasis. DFSP occurs most commonly on the trunk and proximal extremities, affects all races, and often develops between the second and fifth decade of life. The tumor grows slowly, typically over years. Histologically, several variants of DFSP have been described and should be well characterized to avoid misdiagnosis with other tumors. These include pigmented (Bednar tumor), myxoid, myoid, granular cell, sclerotic, atrophic DFSP, giant cell fibroblastoma, and DFSP with fibrosarcomatous areas. Of all these variants, only the DFSP with fibrosarcomatous areas is…
Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1-PDGFB ) study with therapeutic implications.
2009
Aims: To analyse the presence of collagen type I alpha 1–platelet-derived growth factor beta (COL1A1–PDGFB) transcripts in 20 cases of dermatofibrosarcoma protuberans (DFSP) and to assess the relationship between COL1A1 breakpoints and clinical and histopathological variables. Methods and results: Multiplex reverse transcriptase-polymerase chain reaction was carried out using frozen tissue. Our series contained 14 men and six women. Histologically, most cases were of conventional type (n = 9), followed by fibrosarcoma (n = 4), Bednar tumour (n = 2), sclerosing (n = 2), myoid (n = 1) and atrophic (n = 1) DFSP, and giant cell fibroblastoma (n = 1). Immunohistochemistry revealed CD34 express…