Search results for "first"
showing 10 items of 1149 documents
Efficacy and safety of ramucirumab (RAM) for advanced hepatocellular carcinoma (HCC) with elevated alpha-fetoprotein (AFP) following first-line soraf…
2019
Abstract Background REACH (NCT01140347) and REACH-2 (NCT02435433) were two global, randomized, double-blind, placebo (PL)-controlled multicenter, phase 3 studies of RAM vs PL in patients with HCC after prior sorafenib. REACH-2 confirmed overall survival (OS) benefit of RAM for patients with baseline AFP ≥400ng/mL, consistent with results in a prespecified subgroup of patients in REACH with AFP ≥400ng/mL. Methods Post-hoc pooled analyses were performed to examine efficacy and safety in three age subgroups ( Results Both intention-to-treat populations were pooled (542 patients in total). Within each age subgroup, baseline characteristics between treatment arms were similar. Patients of Conclu…
FUZZY RISK ANALYSIS OF A MODERN γ-RAY INDUSTRIAL IRRADIATOR
2011
Fuzzy fault tree analyses were used to investigate accident scenarios that involve radiological exposure to operators working in industrial γ-ray irradiation facilities. The HEART method, a first generation human reliability analysis method, was used to evaluate the probability of adverse human error in these analyses. This technique was modified on the basis of fuzzy set theory to more directly take into account the uncertainties in the error-promoting factors on which the methodology is based. Moreover, with regard to some identified accident scenarios, fuzzy radiological exposure risk, expressed in terms of potential annual death, was evaluated. The calculated fuzzy risks for the examine…
G. Herglotz’ Behandlung von Beschleunigungswellen in seiner Vorlesung «Mechanik der Kontinua» angewandt auf die Stosswellen von Christoffel
1981
Following a lecture delivered by Herglotz in 1925/26 we briefly treat acceleration waves in hyperelastic materials. Our main result is a divergence equation for the squared Euclidean norm of the so-called ‘wave vector’. We then apply Herglotz’ method (devised for acceleration waves) to the propagation of such first order discontinuities in elastic bodies as were treated by Christoffel in [1].
The English Pronunciation Teaching in Europe Survey : Factors Inside and Outside the Classroom
2015
In the past two decades, a number of studies have looked at how English pronunciation is taught, focusing on teaching practices, materials, training and attitudes to native speaker models from both the teachers’ and the learners’ perspective. Most of these studies have been conducted in English-speaking countries such as the USA (Murphy, 1997), Great Britain (Bradford and Kenworthy, 1991; Burgess and Spencer, 2000), Canada (Breitkreutz, Derwing and Rossiter, 2001; Foote, Holtby and Derwing, 2011), Ireland (Murphy, 2011) and Australia (Couper, 2011; Macdonald, 2002). In Europe, pronunciation teaching has been studied in Spain (Walker, 1999) and, more recently, in Finland (Tergujeff, 2012, 20…
New evidence for chunk-based models in word segmentation.
2014
International audience; : There is large evidence that infants are able to exploit statistical cues to discover the words of their language. However, how they proceed to do so is the object of enduring debates. The prevalent position is that words are extracted from the prior computation of statistics, in particular the transitional probabilities between syllables. As an alternative, chunk-based models posit that the sensitivity to statistics results from other processes, whereby many potential chunks are considered as candidate words, then selected as a function of their relevance. These two classes of models have proven to be difficult to dissociate. We propose here a procedure, which lea…
First Award of The Charles François International Prize established by IASCYS
2019
This article describes the circumstances of the establishment of the Charles Francois Prize by the International Academy for Systems and Cybernetic Sciences (IASCYS) and the procedure of its awarding. The role of Charles Francois ’s personality, in the development, popularization, and dissemination of systems thinking, the trans-disciplinary methodology of scientific research and the solution of social and practical problems based on it, is shown.
Vinorelbine and 5-fluorouracil bolus and/or continuous venous infusion plus levofolinic acid as second-line chemotherapy for metastatic breast cancer…
2006
Background: This retrospective study evaluated the activity and toxicity profile of a regimen of vinorelbine and 5-fluorouracil with levofolinic acid, given to a large series of patients with recurrent or refractory metastatic breast cancer after first-line chemotherapy. Patients and Methods: Overall, 286 evaluable patients were included in the analysis. Two chemotherapy schedules were reviewed: a) the bolus regimen consisted of levofolinic acid 100 mg/m(2) and 5-fluorouracil 375 mg/m(2) both administered i.v. on days 1,2 and 3, plus vinorelbine 25 mg/m(2) i.v. bolus on days I and 8 every 3 weeks; b) the infusional regimen of levofolinic acid 100 mg/m(2) given as a 2-hour infusion, followed…
Finite Model Reasoning in Expressive Fragments of First-Order Logic
2017
Over the past two decades several fragments of first-order logic have been identified and shown to have good computational and algorithmic properties, to a great extent as a result of appropriately describing the image of the standard translation of modal logic to first-order logic. This applies most notably to the guarded fragment, where quantifiers are appropriately relativized by atoms, and the fragment defined by restricting the number of variables to two. The aim of this talk is to review recent work concerning these fragments and their popular extensions. When presenting the material special attention is given to decision procedures for the finite satisfiability problems, as many of t…
The Fluted Fragment with Transitivity
2019
We study the satisfiability problem for the fluted fragment extended with transitive relations. We show that the logic enjoys the finite model property when only one transitive relation is available. On the other hand we show that the satisfiability problem is undecidable already for the two-variable fragment of the logic in the presence of three transitive relations.
Quantum algorithm for tree size estimation, with applications to backtracking and 2-player games
2017
We study quantum algorithms on search trees of unknown structure, in a model where the tree can be discovered by local exploration. That is, we are given the root of the tree and access to a black box which, given a vertex $v$, outputs the children of $v$. We construct a quantum algorithm which, given such access to a search tree of depth at most $n$, estimates the size of the tree $T$ within a factor of $1\pm \delta$ in $\tilde{O}(\sqrt{nT})$ steps. More generally, the same algorithm can be used to estimate size of directed acyclic graphs (DAGs) in a similar model. We then show two applications of this result: a) We show how to transform a classical backtracking search algorithm which exam…