Search results for "first"

Residual Vein Thrombosis Improves Screening for Occult Cancer: Results On 537 Patients with Idiopathic Deep Vein Thrombosis

2009

Abstract Abstract 3999 Poster Board III-935 Background Clinical advantage of extensive screening for occult cancer in patients with idiopathic Deep Vein Thrombosis (DVT) is unknown. We have demonstrated that the Residual Vein Thrombosis (RVT)-based screening for occult cancer improves early detection as well as cancer-related mortality (Siragusa S et al. Blood 2007;110(699):OC). Here we report on final analysis of 537 patients over a period of 8 years. Objective of the study We conducted a prospective study evaluating whether a RVT-based screening for cancer is sensitive and influences cancer-related mortality. Study design Prospective with two cohorts of DVT patients: the first cohort was …

Cancer-Related Venous Thrombosis: Residual Vein Thrombosis Improves Screening for Occult Cancer.

2007

Abstract Background. Clinical advantages of extensive screening for occult cancer in patients with idiopathic Deep Vein Thrombosis (DVT) is still debated since this approach improves early detection of cancer but not cancer-related mortality. Recently, we have demonstrated that patients with Residual Vein Thrombosis (RVT), 3 months after DVT, have a high risk for cancer in the subsequent 2 years (Siragusa S et al. Blood2005;106(11):OC262). At the present it is unknown whether RVT assessment may be used to select patients, with idiopathic DVT, who require screening for occult cancer. Objective of the study. We conducted a prospective study evaluating whether a RVT-based screening for cancer …

Colloquium: The Shape of Hadrons

2012

This Colloquium addresses the issue of the shape of hadrons and, in particular, that of the proton. The concept of shape in the microcosm is critically examined. Special attention is devoted to properly define the meaning of shape for bound-state systems of near massless quarks. The ideas that lead to the expectation of nonsphericity in the shape of hadrons, the calculations that predict it, and the experimental information obtained from recent high-precision measurements are examined. Particular emphasis is given to the study of the electromagnetic transition between the nucleon and its first excited state, the Δ(1232) resonance. The experimental evidence is critically examined and compare…

Growing Up to Belong Transnationally: Parent Perceptions on Identity Formation Among Latvian Emigrant Children in England

2019

AbstractAs a result of the wide availability of social media, cheap flights and free intra-EU movement it has become considerably easier to maintain links with the country of origin than it was only a generation ago. Therefore, the language and identity formation among children of recent migrants might be significantly different from the experiences of children of the previous generations. The aim of this paper is to examine the perceptions of parents on the formation of national and transnational identity among the ‘1.5 generation migrant children’ – the children born in Latvia but growing up in England and the factors affecting them. In particular, this article seeks to understand whether…

Atypical perceptual narrowing in prematurely born infants is associated with compromised language acquisition at 2 years of age

2010

Abstract Background Early auditory experiences are a prerequisite for speech and language acquisition. In healthy children, phoneme discrimination abilities improve for native and degrade for unfamiliar, socially irrelevant phoneme contrasts between 6 and 12 months of age as the brain tunes itself to, and specializes in the native spoken language. This process is known as perceptual narrowing, and has been found to predict normal native language acquisition. Prematurely born infants are known to be at an elevated risk for later language problems, but it remains unclear whether these problems relate to early perceptual narrowing. To address this question, we investigated early neurophysiolog…

The lost mother tongue : An interview study with Finnish war children

2015

This article presents the third study of an interview investigation concerning 10 Finnish war children who were evacuated during the World War II to Sweden and who did not return to live in Finland after the war. The focus is on how they remembered or did not remember their early experiences of displacement and on how they expressed thoughts about their childhood and their adult life. We found that all of them as adults still bore signs of trauma. The younger the children were at the time of the evacuation, the more difficult or even impossible it was for them to think or fantasize about the past. It was consequently not possible for them to work through their experiences of loneliness, abs…

444P PRODIGE 25 (FFCD 11-01)-FOLFA: A randomized phase II trial evaluating aflibercept associated with LV5FU2 regimen as first-line treatment of non-…

2020

Complement component C1 and the collectins – first-line defense molecules in innate and acquired immunity

2002

Abstract The 5th International Workshop on C1 and the Collectins was held in Lufthansa-Bildungszentrum, Seeheim, Germany from 26–28 October 2001.

Cabozantinib in Patients with Advanced Renal Cell Carcinoma Primary Refractory to First-line Immunocombinations or Tyrosine Kinase Inhibitors.

2022

Background: A subset of patients with metastatic renal cell carcinoma (mRCC), deemed as primary refractory, shows progressive disease as the best response to first-line therapy even when treated with novel immune-based combos. Objective: We aimed to assess the outcome of patients treated with second-line cabozantinib for mRCC primary refractory to first-line therapy defined as Response Evaluation Criteria in Solid Tumors (RECIST) progression in the computed tomography scan as the best response to the upfront treatment. Design, setting, and participants: We retrospectively collected data from 11 worldwide centers. Outcome measurements and statistical analysis: Overall survival (OS) and progr…

The British Paper Industry, 1800–2000

2012

Britain was the first country in the world to enter into the business of mechanised papermaking. It continued in the lead in the field of papermaking until the 1890s, after which the momentum of being the first nation successfully to mechanise the production of paper was gradually lost to some of its major competitors in North America and Continental Europe. The first part of the twentieth century was characterised by industry growth disturbed by the First World War, the economic depression of the early 1930s and the Second World War. The post-Second World War era signified the decline of the role of the Empire as a market and business-making area for British companies and also the decline …