Search results for "fisiologia"

Flavonoid-induced gastric relaxation: structure-activity relationship and mechanism of action.

2008

Gastric relaxation induced by flavonoids: analysis of the underlying mechanisms.

2008

Dietary flavonols and flavan-3ols as modulators of superoxide radicals production: opposite dose-dependent effects

2012

Modulating activity of dietary flavonols and flavan-3ols on the enzymes xanthina oxidase (XO) and mitochondrial superoxide dismutase (Mn-SOD)

2012

Meshless Electrophysiological Modeling of Cardiac Resynchronization Therapy—Benchmark Analysis with Finite-Element Methods in Experimental Data

2022

Computational models of cardiac electrophysiology are promising tools for reducing the rates of non-response patients suitable for cardiac resynchronization therapy (CRT) by optimizing electrode placement. The majority of computational models in the literature are mesh-based, primarily using the finite element method (FEM). The generation of patient-specific cardiac meshes has traditionally been a tedious task requiring manual intervention and hindering the modeling of a large number of cases. Meshless models can be a valid alternative due to their mesh quality independence. The organization of challenges such as the CRT-EPiggy19, providing unique experimental data as open access, enables b…

Nuove frontiere della fotosintesi clorofilliana: la foglia artificiale

2013

Per molti anni la scienza ha tentato di riprodurre il processo fotosintetico delle piante, che permette di utilizzare la luce del sole e l'anidride carbonica dell'atmosfera per produrre gli zuccheri necessari al loro metabolismo. Nella primavera del 2010 sui quotidiani compare la notizia rivoluzionaria della creazione di una foglia artificiale, capace di trasformare la luce in una fonte di energia utilizzabile dall'uomo. Su quali principi si basa questa scoperta? Quanto ha di analogo con i processi che avvengono nelle foglie? E quanto siamo vicini all'applicazione su vasta scala di questa innovazione tecnologica?

Seasonal pattern of mannitol and malate accumulation in leaves of two manna ash species (Fraxinus ornus L. and F. angustifolia Vahl) growing in Sicily

2002

The content of mannitol and malate was assayed enzimatically during spring, summer and autumn, in leaves of two species of ash traditionally cultivated in Sicily for the extraction of manna. The results suggest that in these species, under the local field conditions, mannitol has a more relevant role than malate in the response to summer drought.

The GABAergic System and the Gastrointestinal Physiopathology.

2015

Since the first report about the presence of γ-aminobutyric acid (GABA) within the gastrointestinal (GI) tract, accumulating evidence strongly supports the widespread representation of the GABAergic system in the enteric milieu, underlining its potential multifunctional role in the regulation of GI functions in health and disease. GABA and GABA receptors are widely distributed throughout the GI tract, constituting a complex network likely regulating the diverse GI behaviour patterns, cooperating with other major neurotransmitters and mediators for maintaining GI homeostasis in physiologic and pathologic conditions. GABA is involved in the circuitry of the enteric nervous system, controlling…

Enhanced tonic GABAA inhibition in typical absence epilepsy

2009

The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired γ-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABAA receptor–dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and GAT-1 is crucial in governing seizure genesis. Extrasynaptic GABAA receptors are a requirement for seizures in two of the best character…

Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: Role of GABAA and GABAC receptors

2007

We investigated, in vitro, the effects of gamma-aminobutyric acid (GABA) on the spontaneous mechanical activity of the longitudinal smooth muscle in mouse duodenum. GABA induced an excitatory effect, consisting in an increase in the basal tone, which was antagonized by the GABA(A)-receptor antagonist, bicuculline, potentiated by (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate (TPMPA), a GABA(C)-receptor antagonist and it was not affected by phaclofen, a GABA(B)-receptor antagonist. Muscimol, GABA(A) receptor agonist, induced a contractile effect markedly reduced by bicuculline, tetrodotoxin (TTX), hexamethonium and atropine. Cis-4-aminocrotonic acid (CACA), a specific GABA(C) …