Search results for "fluids"
showing 10 items of 1936 documents
A double-blind, randomized, dose response study testing the pharmacological efficacy of synthetic porcine secretin
2000
Background: Biologically derived porcine secretin has been used as a diagnostic agent in clinical gastrointestinal practice for many years. Pure synthetic porcine secretin is now available for investigational clinical use. Aim: To compare the pharmacology of synthetic porcine secretin and biologically derived porcine secretin in healthy volunteers. Methods: Secretin stimulation tests were performed in 12 volunteer subjects in a double-blind, randomized, Latin square crossover design study comparing three doses of synthetic porcine secretin (0.05, 0.2, and 0.4 μg/kg) with a standard dose of biologically derived porcine secretin (1 CU/kg). Duodenal aspirates were analysed for total volume and…
Effect of propylene glycol on pre- and post-partum performance by dairy ewes
2005
This study was carried out in order to determine the effects, after feeding propylene glycol to Valle del Belice ewes 30 days prepartum and 30 days postpartum, on metabolic profiles, body-condition score, milk yield, milk composition, milk clotting ability and the performance of suckling lambs. Ewes were blocked by parity, body-condition score and previous milk production, and assigned randomly to either a control diet or a diet containing propylene glycol fed at the rate of 80 g/ewe/day (low PG) or 160 g/ewe/day (high PG). Feeding propylene glycol prepartum decreased the concentration of BHBA and NEFA and increased the concentration of glucose in the ewes’ plasma. Milk yield from ewes fed …
Community detection-based deep neural network architectures: A fully automated framework based on Likert-scale data
2020
[EN] Deep neural networks (DNNs) have emerged as a state-of-the-art tool in very different research fields due to its adaptive power to the decision space since they do not presuppose any linear relationship between data. Some of the main disadvantages of these trending models are that the choice of the network underlying architecture profoundly influences the performance of the model and that the architecture design requires prior knowledge of the field of study. The use of questionnaires is hugely extended in social/behavioral sciences. The main contribution of this work is to automate the process of a DNN architecture design by using an agglomerative hierarchical algorithm that mimics th…
Choice of fluids in critically ill patients
2018
Background Fluids are by far the most commonly administered intravenous treatment in patient care. During critical illness, fluids are widely administered to maintain or increase cardiac output, thereby relieving overt tissue hypoperfusion and hypoxia. Main text Until recently, because of their excellent safety profile, fluids were not considered “medications”. However, it is now understood that intravenous fluid should be viewed as drugs. They affect the cardiovascular, renal, gastrointestinal and immune systems. Fluid administration should therefore always be accompanied by careful consideration of the risk/benefit ratio, not only of the additional volume being administered but also of th…
Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia.
2013
Hypoxic-ischemic insults to the neonatal brain may cause neurodevelopmental disorders. Vulnerability of different areas of the neural tissue to hypoxic-ischemic stress might be explained by either heterogeneous sensitivity to oxygen or neuroprotective capability. Our understanding of regional heterogeneity is still incomplete in terms of metabolic reconfiguration and/or activation of neuroprotective mechanisms.We studied, by western blotting, reverse-transcriptase PCR, and tandem mass spectrometry, the response of retina and choroid at protein, gene, and metabolic levels during hypoxia in a piglet model of acute postnatal hypoxia.We evidenced a metabolic shift towards glycolysis in choroid …
Electrohysterogram Signals from Patients with Threatened Preterm Labor: Concentric Ring Electrode Vs Disk Electrode Recordings
2017
28 Milrinone is Preferred to Levosimendan for Mesenteric Perfusion in Hypoxia-Reoxygenated Newborn Piglets on Dopamine
2010
28 Milrinone is Preferred to Levosimendan for Mesenteric Perfusion in Hypoxia-Reoxygenated Newborn Piglets on Dopamine
FLT3 as a therapeutic target in AML: still challenging after all these years
2010
Abstract Mutations within the FMS-like tyrosine kinase 3 (FLT3) gene on chromosome 13q12 have been detected in up to 35% of acute myeloid leukemia (AML) patients and represent one of the most frequently identified genetic alterations in AML. Over the last years, FLT3 has emerged as a promising molecular target in therapy of AML. Here, we review results of clinical trials and of correlative laboratory studies using small molecule FLT3 tyrosine kinase inhibitors (TKIs) in AML patients. We also review mechanisms of primary and secondary drug resistance to FLT3-TKI, and from the data currently available we summarize lessons learned from FLT3-TKI monotherapy. Finally, for using FLT3 as a molecul…
Effect of seasonality on physico-chemical and microbiological properties of nicastrese milk and artisanal cheese
2021
ABSTRACT Nicastrese is an indigenous Italian goat breed reared in the Calabria region under semi-extensive practices. From January to June, the milk yield of 400 multiparous Nicastrese goats was evaluated. In addition, tank milk and ripened cheese samples were subjected to physico-chemical and microbiological analyses with the aim to assess the effect of the seasonality on quality parameters. The volatile organic compounds profile of the ripened Nicastrese cheese samples was evaluated. Results showed that the seasonality had a significant effect on milk fat, lactose, urea, citric acid contents and acidity. Microbiological analysis of tank milk samples revealed variability among the differen…
Le varianti A1 e A2 della ?-caseina non hanno un effetto significativo sul microbiota del latteThe A1 and A2 ?-casein variants have not impact on mil…
2020
Objective: Milk is composed by a complex microbiota which can be influenced by numerous factors such as the season, the diet, the type of litter, the facility. As well, the animal's genotype can affect the composition of the milk microbiota. In milk, ?-casein is characterized by a high-level of polymorphism. The aim of this study was to verify if A1 and A2 ?-casein variants could in- fluence the milk microbioma. Materials and methods: Thirty Holstein cows were genotyped for ?-casein locus and divided into three groups. In two different sea- sons, milk samples (individual and bulk tank for each experi- mental group) and mozzarella cheese were collected separately from each group. Bacterial D…