Search results for "forensic"

Introduction

2009

The small heat-shock protein α B-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis

2014

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the proliferation of myofibroblasts and the accumulation of extracellular matrix (ECM) in the lungs. TGF-β1 is the major profibrotic cytokine involved in IPF and is responsible for myofibroblast proliferation and differentiation and ECM synthesis. αB-crystallin is constitutively expressed in the lungs and is inducible by stress, acts as a chaperone and is known to play a role in cell cytoskeleton architecture homeostasis. The role of αB-crystallin in fibrogenesis remains unknown. The principal signalling pathway involved in this process is the Smad-dependent pathway. We demonstrate here that αB-crystallin is stron…

Platelet, Not Endothelial, P-Selectin Expression Contributes to Generation of Immunity in Cutaneous Contact Hypersensitivity

2010

Leukocyte extravasation is a prerequisite for host defense and autoimmunity alike. Detailed understanding of the tightly controlled and overlapping sequences of leukocyte extravasation might aid development of novel therapeutic strategies. Leukocyte extravasation is initiated by interaction of selectins with appropriate carbohydrate ligands. Lack of P-selectin expression leads to decreased contact hypersensitivity responses. Yet, it remains unclear if this is due to inhibition of leukocyte extravasation to the skin or due to interference with initial immune activation in lymph nodes. In line with previous data, we here report a decreased contact hypersensitivity response, induced by 2,4,-di…

Transforming growth factors (TGF-alpha and TGF-beta1) in the determination of vitality and wound age: immunohistochemical study on human skin wounds.

2002

In continuation of former investigations on proinflammatory cytokines, in the present study the relevance of the transforming growth factors TGF-alpha and TGF-beta1 was evaluated for the diagnosis of vitality and wound age. Paraffin sections from human skin wounds due to sharp force influence, which had been collected in operations and autopsies, were investigated using immunohistochemistry. The wound age varied from a few minutes to a maximum of 6 weeks with focus on the early post-traumatic interval up to 5h. Samples from uninjured skin were available as controls. TGF-alpha (n=74) was weakly expressed in normal skin and showed a marked increase in epidermal reactivity after a wound age of…

Bipolar Quantum Molecular Resonance versus Blunt Dissection tonsillectomy

2015

Bipolar Quantum Molecular Resonance versus Blunt Dissection tonsillectomy. Objectives: This study compared a quantum molecular resonance tonsillectomy (QMRT) to a standard blunt dissection tonsillectomy (BDT) for effectiveness and safety. Methodology: From January 2011 to September 2012, we recruited 80 children (ages 3 to 16 y) with paediatric obstructive sleep apnoea syndrome and/or recurrent tonsillitis. Patients were randomly assigned to receive QMRT (N = 40) or BDT (N = 40). The operating time and blood loss during surgery were evaluated. During the first postoperative week, the patients' parents completed a questionnaire to evaluate bleeding, ear and neck pain, nausea, vomiting, inter…

Autopsia de un body packer al que le habían extraído la droga siendo cadáver

2015

Existen multitud de métodos empleados por los narcotraficantes para el traslado internacional de la droga, siendo el más peligroso para el individuo el transporte en el interior de su organismo, el denominado “body packer”. En ocasiones, alguno de los paquetes puede romperse y provocar la muerte por la salida masiva del tóxico. El hallazgo del envoltorio roto y el resto de paquetes íntegros, con la droga en su interior, al realizar la autopsia, son muy importantes para el diagnóstico. En el caso que nos ocupa, la previa manipulación del cadáver para extracción y recuperación de la droga, ha dificultado la determinación de la causa de la muerte. There are many methods used by drug trafficker…

Quantitative Anatomical Studies

2015

This special issue of this journal highlights new developments mainly in the field of quantification of the data of anatomical studies. In this special issue, we reviewed and edited seventeen articles from broad ranges of anatomical studies. N. Utkualp and I. Ercan reviewed anthropometric measurement usage in medical sciences from Ancient Egyptian, Greek, and Roman civilizations to those from modern medicine. They also stressed contributions of the well-known scientists to recent diagnostic methods. S. Liao et al. studied the fundamental problem of automatically segmenting teeth in dental mesh models into individual tooth objects and they built a novel dental-targeted harmonic field, which …

Management of demolition phases and related waste, in a building renovation project near Salerno, Italy

2020

Compliance with recent environmental regulations, the demolition phase, within the building replacement process, plays a decisive role, in terms of execution and management methods. The contribution addresses the problems related to the management of the site, in compliance with regulatory requirements for selective demolition and disposal of waste materials. Possible organisational and procedural solutions were investigated with particular reference to the phases of selective demolition (in compliance with Minimum Environmental Criteria), excavation, handling, treatment, recycling, and disposal of waste materials.

Sure he's dead? Be wise.

2013

Investigation of sterols as potential biomarkers for the detection of pig (S. s. domesticus) decomposition fluid in soils

2012

This study was carried out to evaluate the potential of using cholesterol and coprostanol, as indicators for the detection of decomposition fluid of buried pigs (S. s. domesticus) in soils. In May 2007, four pig carcasses (~35. kg) were buried in shallow graves (~40. cm depth) at the University of Ontario Institute of Technology in Canada. Two pigs were exhumed after three months (Pig 1, Pig 2) and six months (Pig 3, Pig 4) post burial. Soil samples were collected beneath the pig carcasses (~40. cm depth) and from grave walls (~15-20. cm depth) as well as from a parallel control site. Coprostanol and cholesterol were extracted from soils, purified with solid phase extraction (SPE) and analy…