Search results for "fragmentation"
showing 10 items of 798 documents
Fragmentation of anthracene C14H10, acridine C13H9N and phenazine C12H8N2 ions in collisions with atoms
2014
International audience; We report experimental total, absolute, fragmentation cross sections for anthracene C14H10, acridine C13H9N, and phenazine C12H8N2 ions colliding with He at center-of-mass energies close to 100 eV. In addition, we report results for the same ions colliding with Ne, Ar, and Xe at higher energies. The total fragmentation cross sections for these three ions are the same within error bars for a given target. The measured fragment mass distributions reveal significant contributions from both delayed (≫10−12 s) statistical fragmentation processes as well as non-statistical, prompt (∼10−15 s), single atom knockout processes. The latter dominate and are often followed by sec…
Masstodon : a tool for assigning peaks and modeling electron transfer reactions in top-down mass spectrometry
2019
Abstract: Top-down mass spectrometry methods are becoming continuously more popular in the effort to describe the proteome. They rely on the fragmentation of intact protein ions inside the mass spectrometer. Among the existing fragmentation methods, electron transfer dissociation is known for its precision and wide coverage of different cleavage sites. However, several side reactions can occur under electron transfer dissociation (ETD) conditions, including nondissociative electron transfer and proton transfer reaction. Evaluating their extent can provide more insight into reaction kinetics as well as instrument operation. Furthermore, preferential formation of certain reaction products can…
Apoptosis in human sperm as a quality marker for a new diagnostic approach of infertile patients
2018
The quality of the sperm DNA is one of the most important molecular markers of male reproductive potential (Bosco, L et al., 2018, Environ Toxicol Pharmacol 58:243-249). The aim of this study was to evaluate sperm DNA fragmentation according to morphology, to predict the probability of selecting a sperm with normal morphology and intact DNA. An observational study was performed on 70 patients with oligoasthenoteratozoospermia. Sperm DNA Fragmentation Index (DFI) and semen parameters such as sperm density, motility and morphology were evaluated in all patients. DFI was calculated using the in situ TUNEL assay. DFI can be determined and thus used as a marker of sperm quality for a diagnostic …
A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-L-ornithine causes cancer cell death by inducing a p53-dependent activation of the mi…
2017
The triphenyltin(IV) compound with N-tert-butoxycarbonyl-L-ornithine (Boc-Orn-OH), [Ph3Sn(Boc-Orn-O)], was synthesized and characterized by elemental analysis, FT-IR, solution1H,13C and119Sn NMR and ESI mass spectrometry. The organotin(IV) compound inhibited at very low micromolar concentrations the growth of human tumor cell lines HepG2 (hepatocarcinoma cells), MCF-7 (mammary cancer) and HCT116 (colorectal carcinoma) while it did not affect the viability of non-malignant human-derived hepatic cells Chang. The mechanism of the antiproliferative effect of Ph3Sn(Boc-Orn-O), investigated on human hepatoma HepG2 cells, was pro-apoptotic, being associated with externalization of plasma membrane …
Fragmentation of polycarbonate macroinitiators in solution and in the bulk state
1990
The diphenylethane initiator 3,4-diethyl-3,4-(p-methoxyphenyl)-hexane (T–OCH3) was synthesized. By cocondensation of bisphenol A or C and the bisphenol derivative (“T”) of T–OCH3 with phosgene, polycarbonate macroinitiators PC(TxA1-x) and PC(TxC1-x) with different compositions x were made. The thermal fragmentation of T–OCH3 and the copolycarbonates was investigated with and without a radical scavenger both in solution and in the bulk state. The primary dissociation of T–OCH3 is a monomolecular Arrhenius process with a characteristic temperature of T* (τ = 1h) = 140°C (τ: average life time of the intact molecule). When the radicals are not intercepted, the dissociation is excessively revert…
In-medium jet shape from energy collimation in parton showers: Comparison with CMS PbPb data at 2.76 TeV
2014
Abstract: We present the medium-modified energy collimation in the leading-logarithmic approximation (LLA) and next-to-leading-logarithmic approximation (NLLA) of QCD. As a consequence of more accurate kinematic considerations in the argument of the Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) fragmentation functions (FFs) we find a new NLLA correction O ð α s Þ which accounts for the scaling violation of DGLAP FFs at small x . The jet shape is derived from the energy collimation within the same approximations and we also compare our calculations for the energy collimation with the event generators PYTHIA 6 and Y A JEM for the first time in this paper. The modification of jets by the …
ATLAS measurements of the properties of jets for boosted particle searches
2012
Measurements are presented of the properties of high transverse momentum jets, produced in proton-proton collisions at a center-of-mass energy of √s=7 TeV. The data correspond to an integrated luminosity of 35 pb−1 and were collected with the ATLAS detector in 2010. Jet mass, width, eccentricity, planar flow and angularity are measured for jets reconstructed using the anti-kt algorithm with distance parameters R=0.6 and 1.0, with transverse momentum pT>300 GeV and pseudorapidity |η|<2. The measurements are compared to the expectations of Monte Carlo generators that match leading-logarithmic parton showers to leading-order, or next-to-leading-order, matrix elements. The generators describ…
Complementary online aerosol mass spectrometry and offline FT-IR spectroscopy measurements: Prospects and challenges for the analysis of anthropogeni…
2017
Abstract The aerosol mass spectrometer (AMS) is well established in investigating highly time-resolved dynamics of submicron aerosol chemical composition including organic aerosol (OA). However, interpretation of mass spectra on molecular level is limited due to strong fragmentation of organic substances and potential reactions inside the AMS ion chamber. Results from complementary filter-based FT-IR absorption measurements were used to explain features in high-resolution AMS mass spectra of different types of OA (e.g. cooking OA, cigarette smoking OA, wood burning OA). Using this approach some AMS fragment ions were validated in this study as appropriate and rather specific markers for a c…
A study on the fragmentation of sulfuric acid and dimethylamine clusters inside an atmospheric pressure interface time-of-flight mass spectrometer
2022
Abstract. Sulfuric acid and dimethylamine vapours in the atmosphere can form molecular clusters, which participate in new particle formation events. In this work, we have produced, measured, and identified clusters of sulfuric acid and dimethylamine using an electrospray ionizer coupled with a planar-differential mobility analyser, connected to an atmospheric pressure interface time-of-flight mass spectrometer (ESI–DMA–APi-TOF MS). This set-up is suitable for evaluating the extent of fragmentation of the charged clusters inside the instrument. We evaluated the fragmentation of 11 negatively charged clusters both experimentally and using a statistical model based on quantum chemical data. Th…
Cold recycling of reclaimed asphalt pavements
2018
Pavement engineers have in front of them multiple challenges linked to addressing issues related to social development and society’s expanding needs. One of the most substantial of these issues is perhaps how to effectively rehabilitate and/ or maintain the existing road network while preserving and sustaining limited natural resources. The re-usage of existing pavement materials to reconstruct/ rehabilitate our future pavements is the solution that is now more and more selected by the different road administrations around the world. However, upon closer inspection, one can find many areas and details, not negligible issues, that are simply extensions of HMA technology (i.e. mix design proc…