Search results for "function"
showing 10 items of 14432 documents
Interferon α interferes with immunological tolerance.
2013
The ability of regulatory T cells (Tregs) to promote immunological tolerance represents an important obstacle in cancer immunotherapy. We have recently discovered that the clinically established immunotherapeutic agent interferon α (IFNα) inactivates the suppressive functions of human Tregs. Here, we outline the mechanisms whereby IFNα mediates this important function and discuss its therapeutic implications for cancer immunotherapy.
Anonymization as homeomorphic data space transformation for privacy-preserving deep learning
2021
Industry 4.0 is largely data-driven nowadays. Owners of the data, on the one hand, want to get added value from the data by using remote artificial intelligence tools as services, on the other hand, they concern on privacy of their data within external premises. Ideal solution for this challenge would be such anonymization of the data, which makes the data safe in remote servers and, at the same time, leaves the opportunity for the machine learning algorithms to capture useful patterns from the data. In this paper, we take the problem of supervised machine learning with deep feedforward neural nets and provide an anonymization algorithm (based on the homeomorphic data space transformation),…
Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering an…
2021
To efficiently lower virus infectivity and combat virus epidemics or pandemics, it is important to discover broadly acting antivirals. Here, we investigated two naturally occurring polyphenols, Epigallocatechin gallate (EGCG) and Resveratrol (RES), and polyphenol-functionalized nanoparticles for their antiviral efficacy. Concentrations in the low micromolar range permanently inhibited the infectivity of high doses of enteroviruses (107 PFU/mL). Sucrose gradient separation of radiolabeled viruses, dynamic light scattering, transmission electron microscopic imaging and an in-house developed real-time fluorescence assay revealed that polyphenols prevented infection mainly through clustering of…
From agricultural to tourist production
2010
This contribution starts off from taking account of the crisis in the agricultural sector. This sector has been “trivialised” by erroneous policies and market rules. However, at present the trend is changing: “demand for environment” is increasing, as well as the attempt of taking actions and policies favouring sustainable development. At the same time, notwithstanding the different meanings attached to the concept of sustainability, a wave of revaluation of rural areas is rising: the countryside is now considered as a source of local cultural values. Its exploitation as a tourist attraction, which is progressively taking off, is to be considered in this context. Natural and cultural assets…
From agricultural to tourist production
2009
The article explores the tourism supply possibilities related to agricultural production.
Tractional Motion Machines extend GPAC-generable functions
2012
In late 17th century there appeared the Tractional Motion instruments, mechanical devices which plot the curves solving differential equations by the management of the tangent. In early 20th century Vannevar Bush’s Differential Analyzer got the same aim: in this paper we’ll compare the Differential Analyzer mathematical model (the Shannon’s General Purpose Analog Computer, or GPAC) with the Tractional Motion Machine potentials. Even if we will not arrive in defining the class of the functions generated by Tractional Motion Machines, we’ll see how this class will strictly extend the GPAC-generable functions.
Traffic proximity and lung function. A case-control study in asthmatic children
2015
Introduction: Respiratory conditions are strongly dependent on air pollution. Urban areas are typically characterized by risky environmental conditions. Objectives: To analyze the effect of traffic proximity on asthma and to explore the relationship between level of traffic proximity and lung function in asthmatic and non- asthmatic children. Methods: A case-control study on children visited for suspected respiratory diseases at IBIM from 2011 to 2014 was performed. All the children have been geocoded according to their residence address. Exposure to traffic air pollution was assessed through determination of number and types of streets in proximity of the place of residence. The relationsh…
Mejorando la comprensión lectora: Desde la intervención metacognitiva en estrategias a la intervención en los procesos ejecutivos de la memoria opera…
2013
Many students may read fluently but have difficulties constructing meaning from texts. Difficulties with reading comprehension have many implications at school. In particular, problems understanding texts interfere with studying and learning from text. Reading comprehension has improved in the last 30 years focusing on intervention programs that work with strategies in which metacog-nition plays a crucial role. However, recent years have seen relevant advances in the study of the relationship between working memory (WM), particularly executive processes, and reading comprehension. In this paper, we present how the last 20 years of our research has evolved regarding metacognitive interventio…
Euripides’Andromache, a Choral Tragedy
2013
Andrómaca es una tragedia coral por diversas razones: por el papel tan singular que el coro desempeña en ella desde el comienzo mismo; y porque en ella, a través de dos mujeres enfrentadas, Andrómaca y Hermíone, convergen en la trama dramática una serie de parejas/tríos que marcan el discurrir de unas sagas épico-dramáticas de gran rendimiento en la tradición cultural y literaria griega. Es también una tragedia coral porque en ella se alcanza el destino fi nal de las dos partes implicadas en la mayor guerra mítica de la Antigüedad. Andromache is a choral tragedy because the singular role of the chorus in the whole play and because in its plot there is a group of couples/trios, which lead th…
Organocatalytic Enantioselective Vinylogous Henry Reaction of 3,5-Dimethyl-4-nitroisoxazole with Trifluoromethyl Ketones
2017
The enantioselective vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole with trifluoromethyl ketones employing a bifunctional squaramide organocatalyst has been developed. A series of isoxazole bearing trifluoromethyl-substituted tertiary alcohols, 2-substituted (R)-1,1,1-trifluoro-3-(3-methyl-4-nitroisoxazol-5-yl)propan-2-ols, were obtained under these mild reaction conditions in good yields and moderate to good enantioselectivities