Search results for "functional"
showing 10 items of 4822 documents
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?
2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.
Analogia e omologia: la questione della filogenesi delle emozioni
2013
Aim of this paper is to outline a new evolutionary interpretation of aesthetic emotions, in the light of the most recent developments in Evolutionary Biology, in particular the so-called “Extended Synthesis of Evolution” (Pigliucci-Müller 2010). Focussing on the biological concept of homology, the Author argues that, in order to effectively understand role and evolutionary value of aesthetic emotions, it should be asked not “what aesthetic emotions are for?”, rather “what kind of constraints and homologies influence the specific “shape” of human aesthetic emotions?”. In a few words, we should move from a functionalist approach to human aesthetic emotions towards a morphological one.
La percepción de la funcionalidad familiar. Confirmación de su estructura bifactorial (The perception of the family functionality. Confirmation of it…
2012
Valid, reliable and easy-to-use instruments are required for the assessment of family functionality. The present study confirms the two-factor structure of a 23-item family Functionality Scale, providing indices of reliability and external validity in a sample of 185 families with teenage children. Parent discrepancy is analyzed, and the statistical descriptors of this variable are presented in the two dimensions that constitute the scale: Facilitator and Disturber. The instrument is useful for assessing functionality and for calculating parental discrepancy in the perception of family life, which is also an indicator of functionality.
Relationship Between the Critical Power Test and a 20-min Functional Threshold Power Test in Cycling.
2021
To investigate the agreement between critical power (CP) and functional threshold power (FTP), 17 trained cyclists and triathletes (mean ± SD: age 31 ± 9 years, body mass 80 ± 10 kg, maximal aerobic power 350 ± 56 W, peak oxygen consumption 51 ± 10 mL⋅min–1⋅kg–1) performed a maximal incremental ramp test, a single-visit CP test and a 20-min time trial (TT) test in randomized order on three different days. CP was determined using a time-trial (TT) protocol of three durations (12, 7, and 3 min) interspersed by 30 min passive rest. FTP was calculated as 95% of 20-min mean power achieved during the TT. Differences between means were examined using magnitude-based inferences and a paired-samples…
Motor Cortex Function in Fibromyalgia: A Study by Functional Near-Infrared Spectroscopy
2019
Previous studies indicated changes of motor cortex excitability in fibromyalgia (FM) patients and the positive results of transcranial stimulation techniques. The present study aimed to explore the metabolism of motor cortex in FM patients, in resting state and during slow and fast finger tapping, using functional Near-Infrared Spectroscopy (fNIRS), an optical method which detects in real time the metabolism changes in the cortical tissue. We studied 24 FM patients and 24 healthy subjects. We found a significant slowness of motor speed in FM patients compared to controls. During resting state and slow movement conditions, the metabolism of the motor areas was similar between groups. The oxy…
Well-being and functional abilities in nursing home and home living seniors in Latvia
2018
The society in developed countries is aging. 1.5% of seniors live in nursing homes in Latvia.Aim: to compare functional abilities and well-being between nursing home and home living Latvian seniors.Methods:280 home living seniors and 285 from nursing homes, age ≥ 65 years able to respond to questions and stand up were included in the study based on availability. They were asked to describe their well-being from very bad to very good. The functional abilities were assessed by hand grip strength, the ability to stand up without assistance, the dependence on caregivers (1 – independent, 2 – partly dependent, 3 – fully dependent), the use of walking device assistance devices.Results:The home li…
The Influence of Fatigue on Throwing and YBT-UQ Performance in Male Adolescent Handball Players
2020
Purpose: The goal of the present study was to assess the effects of fatigue on throwing and Upper Quarter Y Balance Test (YBT-UQ) performance in male adolescent handball players. We hypothesized that throwing and YBT-UQ performance will be decreased in response to an upper-body fatigue-protocol.Method: All male participants (N = 24, age: 14.8 ± 0.7 yrs) were handball players of a regional youth selection team. A radar gun was used for the assessment of throwing velocity. The YBT-UQ was executed assessing medial, inferolateral and superolateral reach directions normalized to the upper limb length together with a composite score. Immediately following a fatigue protocol of different sets of p…
A Group-Based 8-Week Functional Interval-Type Outdoor Training Program Improves Physical Performance in Recreationally Active Adults
2022
Even though physical activity is an important aspect of health, lack of time or motivation impede people from working out regularly. One type of training program that is both efficient and motivating is functional interval-type outdoor training. To evaluate this, our study had 81 participants complete a battery of physical performance tests (incremental treadmill test, core stability test and functional fitness test) before and after an 8-week outdoor interval-type training intervention. Training procedures included multimodal and high-intensity exercises performed in consistent, small groups. Results showed that the interval training program produced significant increases in the interventi…
Prompt and delayed spectroscopy of 203At : Observation of a shears band and a 29/2+ isomeric state
2018
Using fusion-evaporation reactions, a gas-filled recoil separator, recoil-gating technique and recoil-isomer decay tagging technique we have extended the level scheme of 203 At ( N = 118 ) significantly. We have observed an isomeric [ τ = 14.1 ( 3 ) μ s ] state with a spin and parity of 29 / 2 + . The isomeric state is suggested to originate from the π ( h 9 / 2 ) ⊗ ∣ ∣ 202 Po ; 11 − ⟩ coupling, and it is depopulated through 286 keV E 2 and 366 keV E 3 transitions. In addition, we have observed a cascade of magnetic-dipole transitions which is suggested to be generated by the shears mechanism. peerReviewed
Symbiotic status alters fungal eco‐evolutionary offspring trajectories
2023
Despite host-fungal symbiotic interactions being ubiquitous in all ecosystems, understanding how symbiosis has shaped the ecology and evolution of fungal spores that are involved in dispersal and colonization of their hosts has been ignored in life-history studies. We assembled a spore morphology database covering over 26,000 species of free-living to symbiotic fungi of plants, insects and humans and found more than eight orders of variation in spore size. Evolutionary transitions in symbiotic status correlated with shifts in spore size, but the strength of this effect varied widely among phyla. Symbiotic status explained more variation than climatic variables in the current distribution of…