Search results for "fusion"
showing 10 items of 4513 documents
Structural assessment of a whole toroidal sector of the HELIAS 5-B breeding blanket
2021
Abstract The European roadmap for the realization of fusion energy considers the stellarator line as a possible long-term alternative to a tokamak DEMO. In this context, from the plasma physics standpoint, the most promising option is a five-field period power plant called HELIcal-axis Advanced Stellarator (HELIAS) 5-B. In order to allow the electricity production, the HELIAS 5-B reactor must be endowed with a breeding blanket (BB). Hence, in this paper, the advancements in the HELIAS 5-B BB design are reported. In particular, the structural assessment of a whole BB period, extending along toroidal direction for 72 °, is depicted. A geometric configuration encompassing dummy BB segments has…
Preliminary structural assessment of the HELIAS 5-B breeding blanket
2019
Abstract The European Roadmap to the realisation of fusion energy, carried out by the EUROfusion consortium, considers the stellarator concept as a possible long-term alternative to a tokamak fusion power plant. To this purpose a pivotal issue is the design of a HELIcal-axis Advanced Stellarator (HELIAS) machine equipped with a tritium Breeding Blanket (BB), considering the achievements and the design experience acquired in the pre-conceptual design phase of the tokamak DEMO BB. Therefore, within the framework of EUROfusion Work Package S2 R&D activity, a research campaign has been launched at KIT. The scope of the research has been the determination of a preliminary BB segmentation scheme …
Validation of Multi-Physics Integrated Procedure for the HCPB Breeding Blanket
2019
The wide range of requirements and constraints involved in the design of nuclear components for fusion reactors makes the development of multi-physics analysis procedures of utmost importance. In the framework of the European DEMO project, the Karlsruhe Institute of Technology (KIT) is dedicating several efforts to the development of a multi-physics analysis tool allowing the characterization of breeding blanket design points which are consistent from the neutronic, thermal-hydraulic and thermal-mechanical points of view. In particular, a procedure developed at KIT is characterized by the implementation of analysis software only. A preliminary step for the validation of such a procedure ha…
ARCHITECTURAL SURVEY TECHNIQUES FOR DEGRADATION DIAGNOSTICS. AN APPLICATION FOR THE CULTURAL HERITAGE
2021
Abstract. The great technological development in recent years in the field of architectural survey has made possible increasingly expeditious and less invasive investigations with the aim of acquiring a series of data related to the asset and fundamental for the protection of cultural heritage. In addition, the synergy between the various techniques represents an added value able, not only, to fill possible gaps and lacks arising from application limits of the instruments, but also to enhance the peculiarities of the same. This paper presents an integrated survey activity (range-based, image-based and IR thermography techniques) aimed at applying the combination and collaboration of multipl…
Overview of the JET results in support to ITER
2017
The 2014–2016 JET results are reviewed in the light of their significance for optimising the ITER research plan for the active and non-active operation. More than 60 h of plasma operation with ITER first wall materials successfully took place since its installation in 2011. New multi-machine scaling of the type I-ELM divertor energy flux density to ITER is supported by first principle modelling. ITER relevant disruption experiments and first principle modelling are reported with a set of three disruption mitigation valves mimicking the ITER setup. Insights of the L–H power threshold in Deuterium and Hydrogen are given, stressing the importance of the magnetic configurations and the recent m…
Attitudes and perceptions of faculty members in the process adopting innovation: The OpenCourseWare initiative at the University of Valencia, Spain
2014
The OpenCourseWare project, an open learning resource repository, was established at the University of Valencia between 2008 and2009. It initially consisted of only 10 subjects, none of which was in the field of Health Sciences. The objective of this research was toinvestigate the attitudes and perceptions of faculty members in the field of Health Sciences with regard to the project to identify strategies to increase its use and expand its coverage. We applied Rogers’ innovation-diffusion theory along with a qualitative approach using theoretical sampling, semi-structured interviews and open coding. The results indicate the existence of two categories of faculty members. In the first group,…
A Simple Fusion Method for Image Time Series Based on the Estimation of Image Temporal Validity
2015
High-spatial-resolution satellites usually have the constraint of a low temporal frequency, which leads to long periods without information in cloudy areas. Furthermore, low-spatial-resolution satellites have higher revisit cycles. Combining information from high- and low- spatial-resolution satellites is thought a key factor for studies that require dense time series of high-resolution images, e.g., crop monitoring. There are several fusion methods in the bibliography, but they are time-consuming and complicated to implement. Moreover, the local evaluation of the fused images is rarely analyzed. In this paper, we present a simple and fast fusion method based on a weighted average of two in…
Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity.
2002
Member 4 of human solute carrier family 7 (SLC7A4) exhibits significant sequence homology with the SLC7 subfamily of human cationic amino acid transporters (hCATs) [Sperandeo, Borsani, Incerti, Zollo, Rossi, Zuffardi, Castaldo, Taglialatela, Andria and Sebastio (1998) Genomics 49, 230–236]. It is therefore often referred to as hCAT-4 even though no convincing transport activity has been shown for this protein. We expressed SLC7A4 in Xenopus laevis oocytes, but could not detect any transport activity for cationic, neutral or anionic amino acids or for the polyamine putrescine. In addition, human glioblastoma cells stably overexpressing a fusion protein between SLC7A4 and the enhanced green f…
Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane
2005
We have previously shown that activation of PKC (protein kinase C) results in internalization of hCAT-1 [human CAT-1 (cationic amino acid transporter 1)] and a decrease in arginine transport [Rotmann, Strand, Martiné and Closs (2004) J. Biol. Chem. 279, 54185–54192]. However, others found increased transport rates for arginine in response to PKC activation, suggesting a differential effect of PKC on different CAT isoforms. Therefore we investigated the effect of PKC on hCAT-3, an isoform expressed in thymus, brain, ovary, uterus and mammary gland. In Xenopus laevis oocytes and human U373MG glioblastoma cells, hCAT-3-mediated L-arginine transport was significantly reduced upon treatment with…
Effects of Propofol (Intravenous Propofol Emulsion) on Cell Membranes Measured by Electrofusion and Electroporation
2011
The influence of propofol (CAS 2078-54-8 (intravenous propofol emulsion) on cell membrane properties was investigated in vitro with techniques of cell electrofusion and cell electroporation. Human lymphoma cells and plant protoplasts were chosen as a model system. Propofol (intravenous propofol emulsion) decreased the electrofusion yield of the cells and their membrane permeability. A 50% decrease in relative electrofusion was observed in human lymphoma cells in the presence of about 0.05 mmol/l propofol (intravenous propofol emulsion) and in plant protoplasts in the presence of about 0.1 mmol/l. The fusion of human lymphoma cells was inhibited to 100% at concentrations higher than 0.2 mmol…