Search results for "future"

Sortase A Inhibitors: Recent Advances and Future Perspectives

2015

Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as antivirulence drugs. Sortase A is a polypeptide of 206 amino acids, which catalyzes two sequential reactions: (i) thioesterification and (ii) transpeptidation. Sortase A is involved in the process of bacterial adhesion by anchoring LPXTG-containing proteins to lipid II. Sortase A inhibitors do not affect bacterial growth, but they restrain the virulence of pathogenic bacterial strains, thereby preventing infections caused by Staphylococcus aureus or other Gram-positive bacteria. The efficacy of the most promising inhibitors needs to be com…

Exploring Differentiated Disintegration in a Post-Brexit European Union

2019

In the aftermath of the British referendum to leave the European Union and the European Commission's ‘White Paper on the Future of Europe’, it is not only time to take stock of the existing literature on differentiated integration, but also to rethink the perimeters of disintegration. We argue that phenomena such as Brexit embrace forms of differentiation which trigger the need for conceptualizing differentiated disintegration altogether. This article first sketches the path of the scholarly debate in a chronological way to grasp the breadth of existing literature. Second, it discusses differentiated disintegration as a potentially new area for research. Mapping several scenarios for future…

Coronal mass ejections in the heliosphere

2010

With the advent of the NASA STEREO mission, we are in a position to perform unique investigations of the evolution of coronal mass ejections (CMEs) as they propagate through the heliosphere, and thus can investigate the relationship between CMEs and their interplanetary counterparts, so-called interplanetary CMEs (ICMEs). ICME studies have been principally limited to single-point, in-situ observations; interpretation of the in-situ characteristics of ICMEs has been used to derive a range of ICME properties which we can now confirm or refute using the STEREO imaging data. This paper is a review of early STEREO CME observations and how they relate to our currently understanding of ICMEs based…

Museums and public value – creating sustainable futures

2013

Central European triathletes dominate Double Iron ultratriathlon – analysis of participation and performance 1985–2011

2012

Katrin Sigg,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Patrizia Knechtle,2 Romuald Lepers,3 Thomas Rosemann11Institute of General Practice and Health Services Research, University of Zurich, Zurich; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: A recent study showed that European triathletes performed faster in Double Iron ultratriathlons than North American athletes. The present study analyzed triathletes participating in Double Iron ultratriathlons to determine the origin of the fastest Double Iron ultratriathletes, focusing on European countries.Methods: Participation and perf…

Hopes and fears of teacher candidates concerning the teaching profession

2017

Romanian university students have the opportunity to enroll in the education program for the teaching profession starting with their first year at the university. Most undergraduates choose the education program for the teaching profession, although some of them do not see themselves as teachers. The schooling experiences, the motivation for entering the teacher education programs, the initial teacher education experiences and their future plans can be important factors in considering the perspective of becoming a teacher or not. Focused on a future orientation, the goal of this study was to investigate teacher education candidates’ hopes and fears concerning a possible career as teacher. U…

Predictive variables of happiness in private sports centres

2018

The psychological investigation of happiness has increased significantly in recent decades to the point of becoming one of the most researched behaviours in the new field of Positive Psychology. However, relatively little progress has been made in happiness research and tests to evaluate happiness, and the Oxford Happiness Inventory (OHI), built by Argyle, Martin and Crossland (1989), is among the best-known and most accredited. Happiness has represented a challenging and frustrating quest for humanity, as there is no consensus on its definition. Bearing in mind that there are many ambiguous factors that can affect the happiness of the individual, this study focuses on analysing the variabl…

Multilepton dark matter signals

2020

The signatures of dark matter at the LHC commonly involve, in simplified scenarios, the production of a single particle plus large missing energy, from the undetected dark matter. However, in $Z'$-portal scenarios anomaly cancellation requires the presence of extra dark leptons in the dark sector. We investigate the signatures of the minimal scenarios of this kind, which involve cascade decays of the extra $Z'$ boson into the dark leptons, identifying a four-lepton signal as the most promising one. We estimate the sensitivity to this signal at the LHC, the high-luminosity LHC upgrade, a possible high-energy upgrade, as well as a future circular collider. For $Z'$ couplings compatible with c…

Pilot study on the validity of the pupillographic sleepiness test in children and adolescents

2013

Abstract Objective To report preliminary validation data for the pupillographic sleepiness test (PST) in children and adolescents. Methods Twelve patients (13.1±4.4years of age) underwent the multiple sleep latency test (MLST) and three PSTs at 09:00, 11:00, and 13:00 on one single day. Correlations were tested between mean sleep latency and gender-adjusted z -values of the natural logarithm of the pupillary unrest index (zlnPUI). Results Spearman's correlation ( P -value) between the zlnPUI values obtained at 09:00 and 11:00 with the MSL was r S =−0.641 (0.025) and r =−0.553 (0.062). Conclusion There was satisfactory agreement between PST and the MLST, which is similar to what is found in …

Recent progress on the characterization of the high-pressure behaviour of AVO4 orthovanadates

2018

AVO4 vanadates are materials of technological importance due to their variety of functional properties. They have applications as scintillators, thermophosphors, photocatalysts, cathodoluminescence, and laser-host materials. Studies at HP-HT are helpful for understanding the physical properties of the solid state, in special, the phase behavior of AVO4 materials. For instance, they have contributed to understand the macroscopic properties of vanadates in terms of microscopic mechanisms. A great progress has been made in the last decade towards the study of the pressure-effects on the structural, vibrational, and electronic properties of AVO4 compounds. Thanks to the combination of experimen…