Search results for "g factor"
showing 10 items of 514 documents
On the Non-uniform Redundancy of Representations for Grammatical Evolution: The Influence of Grammars
2018
The representation used in grammatical evolution (GE) is non-uniformly redundant as some phenotypes are represented by more genotypes than others. This article studies how the non-uniform redundancy of the GE representation depends on various types of grammars. When constructing the phenotype tree from a genotype, the used grammar determines Bavg, the average branching factor. Bavg measures the expected number of non-terminals chosen when mapping one genotype codon to a phenotype tree node. First, the paper illustrates that the GE representation induces a bias towards small trees. This bias gets stronger with lower Bavg. For example, when using a grammar with Bavg = 0.5, 75% of all genotype…
Role of colony‐stimulating factors in the biology of acute myelogenous leukemia
1989
A high proportion of acute myeloid leukemias (AML) recently investigated for their capacity to synthesize biologically active bioregulatory molecules was found to accumulate messenger (m) RNA and to produce membrane-bound or -secreted forms of stimulating factors for granulocyte, macrophage and mixed granulocyte-macrophage colony growth. Blast cells have also been found to secrete interleukin 1, tumor necrosis factor-alpha, interleukin 6, and to express receptors for various growth factors as well. However, growth factors like interleukin 2 and interleukin 3 have not been identified as AML products, and several other factors including interleukin 4, interleukin 5, etc. need further evaluati…
Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells…
2008
International audience; Purpose: To characterize the possible cytotoxic effects of oxysterols (7-hydroxycholesterol (7-OH), 25-hydroxycholesterol (25-OH)) in human retinal pigment epithelial cells (ARPE-19) and to detail the relationships between some of these effects. Methods: ARPE-19 cells were treated with 7-OH and 25-OH. Cell viability was measured with the MTT assay. Membrane permeability, mitochondrial potential, and lysosomal integrity were measured by flow cytometry with propidium iodide, DiOC6(3), and acridine orange, respectively. Cell death was characterized by staining with Hoechst 33342, transmission electron microscopy, and analysis of the DNA fragmentation pattern. Caspase ac…
Evaluation of in-farm versus weather station data for use as heat stress indicator in dairy sheep
2005
AbstractHeat stress is a limiting factor in dairy production in hot climates impairing growth, milk production and reproduction. The most widely investigated climatic factors related with heat stress are: air temperature and relative humidity. Previously dairy sheep studies of heat tolerance depended on measurements of physiological functions on individual animals such as rectal temperatures, respiration rates or volumes of air inhaled; unfortunately, such measurements are costly and not feasible on a large scale. This study aims to evaluate in-farm (IF) versus weather station (WS) data to be used as heat stress indicator in dairy sheep. Data were collected in three farms in November 2002 t…
Urticaria in children and adolescents: An updated review of the pathogenesis and management
2018
The present survey represents the latest data on diagnosis and management of childhood urticaria. It has been observed that urticaria occurs less often in children than adults, with symptoms rarely lasting for over 6 weeks. Triggers or aggravating factors can be found only in 21%-55% of cases. Finding autoantibodies in children does not impact a disease prognosis, unlike in adult patients, where the presence of autoantibodies is associated with a more prolonged run of the disease, a more severe prognosis and more intensive treatment methods. The incidence of food allergy equals to 8%-10% of cases. The incidence of Helicobacter Pylori infection in children is lower than that in adults and co…
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Stimulation of pancreas and gastric carcinoma cell growth by interleukin 3 and granulocyte-macrophage colony-stimulating factor.
1991
Hematopoietic growth factors have recently been well characterized by complementary DNA scloning. For human epidermal growth factor, granulocyte-macrophage colony-stimulating factor recombinant proteins have been expressed in Escherichia coli . To reduce the toxic side effects of chemotherapy on the bone marrow, recombinant human granulocyte-macrophage colony—stimulating factor and recombinant human interleukin 3 were applied to patients suffering of gastrointestinal cancers. To determine the influence of recombinant human granulocyte-macrophage colony—stimulating factor and recombinant human interleukin 3 on human pancreas and gastric cancer cell cells in vitro, a sensitive microculture te…
Serum BLYS/BAFF levels in acute hepatitis C predict clinical outcome
2008
630 SERUM BLYS/BAFF LEVELS IN ACUTE HEPATITIS C PREDICT CLINICAL OUTCOME
2008
Indefinite integrals for some orthogonal polynomials obtained using integrating factors
2020
A method has been presented recently for deriving integrals of special functions using two kinds of integrating factor for the homogeneous second-order linear differential equations which many spec...