Search results for "g factor"
showing 10 items of 514 documents
Delayed healing of chronic leg ulcers can result from impaired trafficking of bone marrow-derived precursors of keratinocytes to the skin
2006
In this paper, it is hypothesized that in chronic wounds the process of homing of bone marrow-derived precursors of keratinocytes is disturbed, and that the interaction between cutaneous T-cell attracting chemokine (CTACK/CCL27) and soluble P-selectin glycoprotein ligand-1 (PSGL-1) can be the cause of this impairment. Several studies have revealed that bone marrow-derived cells (BMDC) trans-differentiate into various cellular lineages, and probably they participate also in healing of wounded skin. Recent studies have demonstrated that BMDC can engraft into the epidermis, and probably they do not engraft into epidermis as keratinocyte stem cells, but rather as transient amplifying cells. So,…
Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo.
2005
AbstractAngiotensin-II (Ang-II) has inflammatory activity and is involved in different diseases associated with the cardiovascular system. This study has evaluated the effect of boldine (B), and two phenanthrene alkaloids semisynthesized by us, secoboldine (SB) and boldine methine (BM), on Ang-II-induced neutrophil recruitment. Intraperitoneal administration of 1 nM Ang-II induced significant neutrophil accumulation, which was maximal at 4–8 h. BM inhibited neutrophil infiltration into the peritoneal cavity at 4 h and 8 h by 73% and 77%, respectively, SB at 8 h by 55%, and B had no effect on this response. Although BM inhibited the release of cytokine-inducible neutrophil chemoattractant/ke…
Granulocyte–Macrophage Colony-Stimulating Factor Is Essential for Normal Wound Healing
2006
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent growth factor, which plays an important role during the process of wound healing. In clinical settings it has occasionally been employed in the treatment of cutaneous wounds of diverse etiologies. In a previous study, we have shown the positive influence of GM-CSF on full thickness excisional wounds in transgenic mice overexpressing GM-CSF in the basal layer of the epidermis. Direct GM-CSF action as well as indirect processes through the induction of secondary cytokines were proposed to contribute towards the beneficial effects. In this study, we analyzed the process of wound healing in transgenic mice overexpressing…
Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multic…
2011
Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G-CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS patients entered an open-label, multicenter trial in which four courses of G-CSF and mannitol were administered at 3-month intervals. Levels of G-CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrea…
Direct Derivation of Corrective Terms in SDE Through Nonlinear Transformation on Fokker–Planck Equation
2004
This paper examines the problem of probabilistic characterization of nonlinear systems driven by normal and Poissonian white noise. By means of classical nonlinear transformation the stochastic differential equation driven by external input is transformed into a parametric-type stochastic differential equation. Such equations are commonly handled with Ito-type stochastic differential equations and Ito's rule is used to find the response statistics. Here a different approach is proposed, which mainly consists in transforming the Fokker–Planck equation for the original system driven by external input, in the transformed probability density function of the new state variable. It will be shown …
Assisted software design of a wide variety of windings in rotating electrical machinery
2014
In this paper a software developed by the Authors for winding design is presented. In particular, this software can be used as a valid aid in design and analysis for a wide variety of windings with generic number of phases, pole pairs, slot number, etc.. The calculation of winding factors and the evaluation of their harmonic distribution is also accomplished. The software is implemented in MATLAB® environment. By means of some examples, covering the most relevant winding types, the capabilities of this software will be shown. Particularly, integer and fractional slot, single and double layer winding, concentrated windings, imbrication, belt widening and belt shifting techniques can be treat…
Flies in the north: locomotor behavior and clock neuron organization of Drosophila montana.
2012
The circadian clock plays an important role in adaptation in time and space by synchronizing changes in physiological, developmental, and behavioral traits of organisms with daily and seasonal changes in their environment. We have studied some features of the circadian activity and clock organization in a northern Drosophila species, Drosophila montana, at both the phenotypic and the neuronal levels. In the first part of the study, we monitored the entrained and free-running locomotor activity rhythms of females in different light-dark and temperature regimes. These studies showed that D. montana flies completely lack the morning activity component typical to more southern Drosophila speci…
Early assessment of crop yield from remotely sensed water stress and solar radiation data
2018
Soil moisture (SM) available for evapotranspiration is crucial for food security, given the significant interannual yield variability of rainfed crops in large agricultural regions. Also, incoming solar radiation (Rs) influences the photosynthetic rate of vegetated surfaces and can affect productivity. The aim of this work is to evaluate the ability of crop water stress and Rs remotely sensed data to forecast yield at regional scale. Temperature Vegetation Dryness Index (TVDI) was computed as an indicator of crop water stress and soil moisture availability. TVDI during critical growth stage of crops was calculated from MODIS products: MODIS/AQUA 8-day composite LST at 1 km and 16-day compos…
Precipitation responses to ENSO and IOD in the Maldives: Implications of large-scale modes of climate variability in weather-related preparedness
2020
Abstract This research seeks to address the extent to which indices of large-scale modes of climate variability (El Nino Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD)) can be linked to physical differences in the local mean and extreme rainfall conditions experienced in the Maldives in order to suggest implications for disaster risk reduction (DRR). While some significant differences in precipitation metrics do occur at the local level between different phases of the large-scale modes of climate variability studied, they do not occur for all sites studied. While the constrained availability of historical meteorological data in the region is a limiting factor in this analysis, th…
Influence of Nutrients and Mixing on the Primary Production and Community Respiration in the Gulf of Riga
1999
Abstract Rates of plankton community production and respiration in relation to wind, solar radiation, biomass and nutrients were measured in the mixed layer during a late spring, a mid-summer and an early autumn situation in the Gulf of Riga. System metabolism was estimated by the in vitro oxygen method and from oxygen mass balance directly in the water. Gross production (GPP) remained fairly stable throughout the investigation periods with a mean of 1.8 g C m−2 day−1 (range: 0.5–3.9 g C m−2 day−1). Community respiration varied from 0.5 to 6.4 g C m−2 day−1 during the two summer studies (the high respiration rates ranging from 3.0 to 10.4 g C m−2 day−1 found during the autumn cruise were pr…