Search results for "ganglion-cells"

showing 2 items of 2 documents

Rev-Erb modulates retinal visual processing and behavioral responses to light

2016

International audience; The circadian clock is thought to adjust retinal sensitivity to ambient light levels, yet the involvement of specific clock genes is poorly understood. We explored the potential role of the nuclear receptor subfamily 1, group D, member 1 (REV-ERB; or NR1D1) in this respect. In light-evoked behavioral tests, compared with wild-type littermates, Rev-Erb(-/-) mice showed enhanced negative masking at low light levels (0.1 lx). Rev-Erb(-/-) mouse retinas displayed significantly higher numbers of intrinsically photosensitive retinal ganglion cells (ipRGCs; 62% more compared with wild-type) and more intense melanopsin immunostaining of individual ipRGCs. In agreement with a…

0301 basic medicineRetinal Ganglion CellsLight[SDV]Life Sciences [q-bio]Circadian clockelectroretinogramBiochemistrychemistry.chemical_compound0302 clinical medicinecircadian clockskin and connective tissue diseasesComputingMilieux_MISCELLANEOUSMice KnockoutipRGCsBehavior AnimalphotoreceptorsorganizationCircadian Rhythmmedicine.anatomical_structurerodtranscriptionBiotechnologyPhotopic visionMelanopsinnegative maskingrat retinaBiologyRetina03 medical and health sciences[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyCircadian ClocksGeneticsmedicineAnimalsCircadian rhythmScotopic visionmelanopsin-knockout miceMolecular BiologymouseRetinaIntrinsically photosensitive retinal ganglion cellsRod OpsinsRetinalganglion-cellsbody regionsmammalian retina030104 developmental biologychemistryNuclear Receptor Subfamily 1 Group D Member 1sense organsNeuroscience030217 neurology & neurosurgeryPhotic Stimulation[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
researchProduct

Indoor artificial lighting: Prediction of the circadian effects of different spectral power distributions.

2014

The study presented in this paper aims to evaluate if and how the environment affects the circadian impact of a light source by predicting circadian stimulus (CS) resulting from the exposure to different light scenes, using equations reported in studies by Rea et al. The main findings are: (1) Above 600 lx at eye level the increase of CS is little; (2) Between 50 lx and 200 lx at the eye level an increase of only 50 lx determines a significant increase of CS; (3) Light sources with correlated colour temperatures between 2900 K and 4200 K have similar impacts on the circadian system according to the calculation method used; (4) Even an almost neutral environment affects the circadian impact…

Light sourceArtificial lightcircadian stimulus spectral power distribution circadian systemComputer scienceMELATONIN CLOCK PHOTOTRANSDUCTION PHOTORECEPTORS MELANOPSIN RHYTHMS HUMANS ROD circadian effects SPDs light sources non visual effectsAcousticsCircadian rhythmElectrical and Electronic EngineeringStimulus (physiology)RETINAL GANGLION-CELLS SYSTEMElectrical and Electronic Engineering circadian rhythmSimulation
researchProduct