Search results for "gap"
showing 10 items of 1144 documents
Management of macular edema due to branch retinal vein occlusion with intravitreal injections of pegaptanib sodium
2009
Purpose To evaluate the efficacy of Pegaptanib Sodium as single therapy for macular edema due to non-ischemic branch retinal vein occlusion. Methods In this uncontrolled prospective pilot study 17 patients have been included with non-ischemic branch retinal vein occlusion. All of them showed macular edema in the OCT with central foveal thickness higher than 350 microns (mean, 541 +/- 140) and decrease in visual acuity lower than 0,5 Snellen ETDRS charts notation (mean, 0,16+/-0,14). After an initial injection of Pegaptanib Sodium evaluations were programmed every 5 weeks and further retreatments were developed in cases with macular thickness higher than 300 microns. No other therapies were …
Assessment of the health care system functioning in Poland in light of the analysis of the indicators of the hospital emergency department (ED) and p…
2019
Background In the last three decades, in developed countries, the number of patients reporting to hospital emergency departments has dramatically increased. The number of visits to EDs can be an important indicator of the quality of primary health care. Objectives To analyse: 1) the frequency of admissions to EDs, 2) the type and number of medical procedures performed in EDs, and 3) the type and number of services provided by PHC in the Kedzierzyn-Kozle district. Material and methods A retrospective analysis of the statistical data regarding services provided by PHC in the Kedzierzyn-Kozle district within the National Health Fund (NHF) and data from the hospital emergency department in Kedz…
Increased Connexin 43 Expression as a Potential Mediator of the Neuroprotective Activity of the Corticotropin-Releasing Hormone
2009
CRH is a major central stress mediator, but also a potent neuroprotective effector. The mechanisms by which CRH mediates its neuroprotective actions are largely unknown. Here, we describe that the gap junction molecule connexin43 (Cx43) mediates neuroprotective effects of CRH toward experimentally induced oxidative stress. An enhanced gap junction communication has been reported to contribute to neuroprotection after neurotoxic insults. We show that CRH treatment up-regulates Cx43 expression and gap junctional communication in a CRH receptor-dependent manner in IMR32 neuroblastoma cells, primary astrocytes, and organotypic hippocampal slice cultures. MAPKs and protein kinase A-cAMP response…
Single Event Transients and Pulse Quenching Effects in Bandgap Reference Topologies for Space Applications
2016
An architectural performance comparison of bandgap voltage reference variants, designed in a $0.18~\mu \text {m}$ CMOS process, is performed with respect to single event transients. These are commonly induced in microelectronics in the space radiation environment. Heavy ion tests (Silicon, Krypton, Xenon) are used to explore the analog single-event transients and have revealed pulse quenching mechanisms in analogue circuits. The different topologies are compared, in terms of cross-section, pulse duration and pulse amplitude. The measured results, and the explanations behind the findings, reveal important guidelines for designing analog integrated circuits, which are intended for space appli…
Hyvää ruokaa ja monta kulttuuria : singaporelaisten arkikokemus monikulttuurisuudesta
2010
Tutkimukseni käsittelee singaporelaisten arkikokemusta monikulttuurisuudesta. Selvitän tutkimuksessani ruoan merkityssisältöä toisen kulttuurin kokemisessa ja tutkin ruoan tarjoamaa rajapintaa kulttuurien välisessä vuorovaikutuksessa. Kuvailen myös minkälaista singaporelainen monikulttuurisuusdiskurssi on ja miten monikulttuurisuus ilmenee singaporelaisten kulttuuri-identiteetissä. Tutkimuksessa olen käyttänyt triangulatiivista eli moniaineistoista metodia. Aineistoni koostuu eri tavoin toteutetuista tutkimushaastatteluista, joista osan toteutin kasvotusten ja osan virtuaalisia menetelmiä, kuten internet-kyselyä hyödyntäen, sekä tekemästäni kenttätyömatkasta Singaporeen. Singapore on moniku…
Effect of lumbar disc replacement on the height of the disc space and the geometry of the facet joints: a cadaver study.
2010
In a study on ten fresh human cadavers we examined the change in the height of the intervertebral disc space, the angle of lordosis and the geometry of the facet joints after insertion of intervertebral total disc replacements. SB III Charité prostheses were inserted at L3-4, L4-5, and L5-S1. The changes studied were measured using computer navigation sofware applied to CT scans before and after instrumentation. After disc replacement the mean lumbar disc height was doubled (p < 0.001). The mean angle of lordosis and the facet joint space increased by a statistically significant extent (p < 0.005 and p = 0.006, respectively). By contrast, the mean facet joint overlap was significantl…
Rates of Upper Facet Joint Violation in Minimally Invasive Percutaneous and Open Instrumentation: A Comparative Cohort Study of Different Insertion T…
2017
Background Minimally invasive pedicle screw placement may have a higher incidence of violation of the superior cephalad unfused facet joint. Study Aims We investigated the incidence and risk factors of upper facet joint violation in percutaneous robot-assisted instrumentation versus percutaneous fluoroscopy-guided and open transpedicular instrumentation. Methods A retrospective study including all consecutive patients who underwent lumbar instrumentation, fusion, and decompression for spondylolisthetic stenosis and degenerative disk disease was conducted between January 2012 and January 2016. All operations were performed by the same surgeon; the patients were divided into three groups acc…
Preliminary Experience with a Novel System of Facet Fixation to Treat Patients with Lumbar Degenerative Disease. A New Perspective in Minimally Invas…
2017
Purpose We report our experience with a novel surgical device for the treatment of lumbar degenerative microinstability. Facet Wedge (DePuy Synthes, Raynham, Massachusetts, United States) is a novel technique of intra-articular lumbar facet fixation that provides a minimally invasive alternative to standard posterior fixation. Materials and Methods From November 2014 to July 2015, 38 patients underwent single-level Facet Wedge implantation. The main surgical indications included herniated disk (18 patients), spinal canal and foraminal stenosis (14 patients), and Meyerding grade I degenerative spondylolisthesis (6 patients). All the patients showed radiologic signs of microinstability: hype…
Kieli(koulutus) ja nationalismi Singaporessa : ratkaisemattomia jännitteitä standardienglannin, äidinkielten ja singlishin välillä
2018
Edellyttääkö kansallistunteen syntyminen koko väestön kesken jaettua ja omaksi koettua kieltä? Singapore tarjoaa mielenkiintoisen esimerkin tapauksesta, jossa vastaus kysymykseen ei ole lainkaan yksiselitteinen. Nationalismin näkökulmasta Singaporen tilanteen tekee erityisen mielenkiintoiseksi se, että valtiojohto pyrkii rakentamaan kansakuntaa ilman kielipolitiikkaa, jossa olisi keskiössä, tai edes läsnä, koko väestölle yhteistä autenttisena pidettyä kieltä. Tämä artikkeli pohjaa pro gradu -tutkielmaani (Slioor 2018) varten tekemääni tutkimustyöhön. Se ei kuitenkaan ole tiivistelmä tutkielman löydöksistä, ja näkökulman valinta on hieman erilainen. Tarkoituksena on esitellä Singaporen tilan…