Search results for "gate"

Interactions, spillovers de connaissance et croissance des économies modernes. Faut-il préférer la globalisation ou la proximité géographique ?

2009

Globalisation and metropolisation in modern economies induce some locational strategies of knowledge based activities towards cities and deeply increase trade and move of ideas across cities. In that context, we study the way knowledge spillovers have influenced the economic growth of 82 European Metropolises over the 1990-2005 period. We model knowledge spillovers across cities according to three specific interaction patterns depending either on geography or on global advanced services or thought a combination of these patterns. We show that the mixed pattern matters the best for economic growth of cities in Europe.

Molecular modelling studies on dopamine-amino acid conjugates as potential dopaminergic modulators

2015

Do testate amoebae communities recover in concordance with vegetation after restoration of drained peatlands?

2016

The environmental importance of peatlands has stimulated efforts to restore their specific ecosystem structure and functions. Monitoring and assessment of the ecological state of the peatland is fundamental in restoration programmes. Most studies have focused on the responses of vegetation and, to a lesser extent, on testate amoebae (TA). To our knowledge, none have investigated whether these two groups show concordance in the context of restoration of drained peatland. Here we assess community concordance between TA and vegetation in boreal peatlands belonging to four different land use management classes (natural, drained, restored 3–7 years ago, and restored 9–12 years ago). TA and veget…

A genomic reappraisal of symbiotic function in the aphid/Buchnera symbiosis: reduced transporter sets and variable membrane organisations.

2011

International audience; Buchnera aphidicola is an obligate symbiotic bacterium that sustains the physiology of aphids by complementing their exclusive phloem sap diet. In this study, we reappraised the transport function of different Buchnera strains, from the aphids Acyrthosiphon pisum, Schizaphis graminum, Baizongia pistaciae and Cinara cedri, using the re-annotation of their transmembrane proteins coupled with an exploration of their metabolic networks. Although metabolic analyses revealed high interdependencies between the host and the bacteria, we demonstrate here that transport in Buchnera is assured by low transporter diversity, when compared to free-living bacteria, being mostly bas…

Quaternary Reversible Circuit Optimization for Scalable Multiplexer and Demultiplexer

2023

Information loss is generally related to power consumption. Therefore, reducing information loss is an interesting challenge in designing digital systems. Quaternary reversible circuits have received significant attention due to their low-power design applications and attractive advantages over binary reversible logic. Multiplexer and demultiplexer circuits are crucial parts of computing circuits in ALU, and their efficient design can significantly affect the processors’ performance. A new scalable realization of quaternary reversible 4×1 multiplexer and 1×4 demultiplexer, based on quaternary 1-qudit Shift, 2-qudit Controlled Feynman, and 2-qudit Muthukrishnan-Stroud gates, is presented in …

Tolerance, Adaptation, and Cell Response Elicited by Micromonospora sp. Facing Tellurite Toxicity: A Biological and Physical-Chemical Characterization

2022

The intense use of tellurium (Te) in industrial applications, along with the improper disposal of Te-derivatives, is causing their accumulation in the environment, where oxyanion tellurite (TeO32−) is the most soluble, bioavailable, and toxic Te-species. On the other hand, tellurium is a rare metalloid element whose natural supply will end shortly with possible economic and technological effects. Thus, Te-containing waste represents the source from which Te should be recycled and recovered. Among the explored strategies, the microbial TeO32− biotransformation into less toxic Te-species is the most appropriate concerning the circular economy. Actinomycetes are ideal candidates in…

Trastuzumab-emtansine induced pleural and pericardial effusions

2021

Introduction Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate which combine trastuzumab (T), a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), and a cytotoxic molecule derived from maytansine (DM1). Case report We report the first case of T-DM1-associated pleural and pericardial effusions three weeks after the second course of T-DM1 in a patient with breast cancer. Drug-induced pleural and pericardial effusions was implicated in the absence of other etiologies. The Naranjo Scale indicated a probable drug-induced adverse reaction. Management & outcome: The patient fully recovered after thoracentesis and discontinuation of T-DM1. The patient h…

Polymer Drug Conjugates for the Treatment of Neurodegenerative Disorders

2013

Nanociencia y nanotecnología son la base de técnicas innovadoras para el transporte de fármacos con beneficios potenciales para el paciente y nuevos mercados para la industria. La obtención de nuevos sistemas de transporte de fármacos más efectivos es uno de los principales retos actuales, junto con la mejora del diagnóstico tanto in vitro como in vivo y el desarrollo de tecnologías para la ingeniería tisular y la medicina regenerativa. Además de ser necesario disponer de moléculas con actividad farmacológica para conseguir terapias efectivas se necesitan su transporte y liberación controlada para llegar a conseguir tratamientos con mayor índice terapéutico. El uso de estrategias de direcci…

Post-Publication Gatekeeping Factors and Practices: Data, Platforms, and Regulations in News Work

2023

The gatekeeping literature has turned to look at the factors and practices that shape gatekeeping in the post-publication environment, i.e., after news has entered circulation. This article adds to the discussion and argues that news workers share gatekeeping power in the post-publication environment with audiences, platforms, and regulations. Further, this study extends the post-publication gatekeeping framework and considers it in the context of datafication. The article aims to broadly understand how (audience) data is part of editorial decision-making in news media from news workers’ perceptions. The current study was conducted by interviewing news workers from three Finnish news organi…

CALIBRATION OF LÉVY PROCESSES USING OPTIMAL CONTROL OF KOLMOGOROV EQUATIONS WITH PERIODIC BOUNDARY CONDITIONS

2018

We present an optimal control approach to the problem of model calibration for L\'evy processes based on a non parametric estimation procedure. The calibration problem is of considerable interest in mathematical finance and beyond. Calibration of L\'evy processes is particularly challenging as the jump distribution is given by an arbitrary L\'evy measure, which form a infinite dimensional space. In this work, we follow an approach which is related to the maximum likelihood theory of sieves. The sampling of the L\'evy process is modelled as independent observations of the stochastic process at some terminal time $T$. We use a generic spline discretization of the L\'evy jump measure and selec…