Search results for "gate"
showing 10 items of 1811 documents
2.14 Selected Diastereoselective Reactions: Enolate Alkylation
2012
This chapter discusses processes in which enolates are subjected to reaction with alkylating reagents. In all the processes examined here, at least one of the two reaction components is chiral and the reaction gives rise to one or more diastereomeric compounds. In most cases, the enolate is generated through deprotonation of the corresponding carbonyl precursor with a suitable base, but in several cases, the enolate is generated differently, for example, through Michael addition of a nucleophile to a conjugated carbonyl compound. The various factors that have been found to influence the stereochemical outcome of the alkylation reaction in a measurable way are also discussed. The material ha…
Gestación por sustitución: Desafíos jurídicos y éticos
2018
El desarrollo de las FIV, y en especial de la gestación por sustitución, los intereses y dignidad del menor y de la madre gestante se ven gravemente afectados y ponen de relieve las dificultades y desafíos a los que se enfrenta hoy el Derecho
Linking content and technology: on the geography of innovation networks in the Bergen media cluster
2017
This paper deals with the geography of innovation networks and analyses combinatorial knowledge dynamics from a single cluster perspective. Addressing firms in the media cluster in Bergen, Norway, we examine how and from where companies acquire and combine different types of knowledge for their innovation activities. The empirical analysis, which is based on structured interviews with 22 media companies, identifies two main types of cluster firms: media content providers that rely heavily on symbolic knowledge and media technology providers that draw mostly on synthetic knowledge. Even though they draw on different knowledge bases, the two types of firms are strongly interlinked in their in…
Mapping and holistic design of natural hydraulic lime mortars
2020
Supplementary data to this article can be found online at https://doi.org/10.1016/j.cemconres.2020.106167.
Immunochromatographic Assay for Quantitation of Milk Progesterone.
1996
We describe a rapid immunochromatographic method for the quantitation of progesterone in bovine milk. The method is based on a 'competitive' assay format using the monoclonal antibody to progesterone and a progesterone-protein conjugate labelled with colloidal gold particles. The monoclonal antibody to progesterone is immobilized as a narrow detection zone on a porous membrane. The sample is mixed with colloidal gold particles coated with progesterone-protein conjugate, and the mixture is allowed to migrate past the detection zone. Migration is facilitated by capillary forces. The amount of labelled progesterone-protein conjugate bound to the detection zone, as detected by photometric scann…
Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride
2012
[EN] The synthesis of capped mesoporous silica nanoparticles (MSN) conjugated with an antibody (AB) as a gatekeeper has been carried out in order to obtain a delivery system able to release an entrapped cargo (dye) in the presence of a target molecule (antigen) to which the conjugated antibody binds selectively. In particular, MSN loaded with rhodamine B and functionalized on the external surface with a suitable derivative of N-(t-butyl)- 3-oxo-(5a,17b)-4-aza-androst-1-ene-17-carboxamide (finasteride) have been prepared (S1). The addition of polyclonal antibodies against finasteride induced capping of the pores due to the interaction with the anchored hapten-like finasteride derivative to g…
A conjugated polymer with ethyl 2-(2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl) acetate units as a novel fluorescent chemosensor for silver(I) detection
2013
Abstract A novel conjugated polymer ( P1 ) containing fluorene and ethyl 2-(2-(pyridin-2-yl)-1 H -benzo[ d ]imidazol-1-yl)acetate (PBMA) was designed and successfully synthesized through the Sonogashira coupling reaction. P1 shows high sensitivity and selectivity for Ag + detection in comparison to other metal cations. Upon addition of Ag + , the fluorescent emission of the polymer solution in THF was quenched dramatically, accompanying the color changed from blue to green. The detection limit for Ag + was 5 × 10 −8 mol L −1 . However, the similar copolymers P2 and P3 containing 2-(pyridin-2-yl)-1 H -benzo[ d ]imidazole and 2-(thiophen-2-yl)-1 H -benzo[ d ]imidazole, respectively, did not …
Performance of the Fully Digital FPGA-Based Front-End Electronics for the GALILEO Array
2014
In this work we present the architecture and results of a fully digital Front End Electronics (FEE) read out system developed for the GALILEO array. The FEE system, developed in collaboration with the Advanced Gamma Tracking Array (AGATA) collaboration, is composed of three main blocks: preamplifiers, digitizers and preprocessing electronics. The slow control system contains a custom Linux driver, a dynamic library and a server implementing network services. The digital processing of the data from the GALILEO germanium detectors has demonstrated the capability to achieve an energy resolution of 1.53 per mil at an energy of 1.33 MeV.
Glycoconjugate vaccines and immune interactions, and implications for vaccination schedules.
2011
Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhancement occurs when two TT conjugates are coadministered. CRM(197) conjugate vaccines induce immune bystander interference when given with diphtheria-tetanus-acellular pertussis vaccines, which reduces responses to coadministered Haemophilus influenzae type b vaccine conjugated to TT. These bystander effects are greater as the amount of CRM(197) administered increases. When large am…
On complete set of solutions for polynomial matrix equations
1990
Abstract In this paper we introduce the concept of co-solution of a polynomial matrix equation which permits us to obtain necessary and sufficient conditions so that a set of solutions be a complete set.