Search results for "gea"
showing 10 items of 1040 documents
Metabolic aggressiveness in benign meningiomas with chromosomal instabilities.
2010
Abstract Meningiomas are often considered benign tumors curable by surgery, but most recurrent meningiomas correspond to histologic benign tumors. Because alterations in chromosome 14 among others have suggested clinical aggressiveness and recurrence, determining both the molecular phenotype and the genetic profile may help distinguish tumors with aggressive metabolism. The aim of this study was to achieve higher specificity in the detection of meningioma subgroups by measuring chromosomal instabilities by fluorescence in situ hybridization and cytogenetics and metabolic phenotypes by high-resolution magic angle spinning spectroscopy. We studied 46 meningioma biopsies with these methodologi…
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
2001
Purpose: Hypoxia shifts the balance of cellular energy production toward glycolysis with lactate generation as a by-product. Quantitative bioluminescence imaging allows for the quantitation of lactate concentrations in individual tumors. We assessed the relationship between pretreatment tumor lactate concentrations and subsequent development of metastatic disease in patients with newly diagnosed head-and-neck cancer. Methods and Materials: At the time of biopsy of the primary site, a separate specimen was taken and flash-frozen for subsequent quantitation of lactate concentration using a luciferase bioluminescence technique. The twodimensional spatial distribution of the bioluminescence int…
Primary optic nerve sheath meningioma
2007
BACKGROUND. Radiotherapy (RT) has occasionally been practiced in the treatment of optic nerve sheath meningioma (ONSM). Recently, stereotactic fractionated RT (SFRT) has been introduced as a tool with better precision for RT delivery. A comprehensive review was undertaken to provide more insight into this matter. METHODS. A literature search was performed to identify reports dealing with both clinical aspects (diagnosis) and treatment in ONSM, focusing on RT in primary (p)ONSM. In particular, major emphasis was placed on the role of SFRT in pONSM. RESULTS. SFRT was capable of achieving excellent local tumor control, with improved/stable functional capacity in ≥80%, accompanied with very low…
Achalasia and carcinoma of the esophagus
1995
Different figures regarding the relationship between achalasia and carcinoma of the esophagus can be found in the literature. Often achalasia is considered as a risk factor. The author analyzing the data collected from the Shanghai Chest Hospital (S.C.H.) and the Pathophysiology Department of the University of Palermo, both referring centers for esophageal diseases conclude that carcinoma of the esophagus in achalasic patients is just a coincidence and no relationship can be found between the two diseases.
Expertise préalable à la création d’un tableau de maladie professionnelle ou à l’élaboration de recommandations aux comités régionaux de reconnaissan…
2022
L’amiante est classé en tant que substance cancérogène avérée pour l’humain (groupe 1 du Centre International de Recherche sur la Cancer (CIRC)) depuis les années 70 pour le poumon et la plèvre. La monographie sur l’amiante actualisée en 2012 indique que des preuves suffisantes sont maintenant disponibles pour démontrer le lien entre l’exposition à l’amiante et les cancers du larynx et de l'ovaire. Dans cette monographie, les cancers du pharynx, de l’estomac et les cancers colorectaux sont considérés comme possiblement liés à une exposition à l’amiante, mais avec un niveau de preuve limité.A ce jour, seuls les cancers broncho-pulmonaires provoqués par l'inhalation de poussières d'amiante [t…
Safety and efficacy of left atrial appendage occlusion with the ACP or Watchman device guided by intracardiac echocardiography from the left atrium
2021
Abstract Background There is a paucity of randomized data regarding the safety and efficacy of the use of intracardiac echocardiography (ICE) from the left atrium (LA) to guide left atrial appendage occlusion (LAAO) procedures under local anesthesia using either of the available devices. Hypothesis The aim of this study was to compare the efficacy and safety of ICE from the LA with transesophageal echocardiography (TEE) for guidance during transcatheter LAAO procedures. Methods Single‐center, cohort study of patients undergoing LAAO with the Amplatzer Cardiac Plug or Watchman device. Procedures were guided by ICE from the LA with local anesthesia (n = 175) or TEE under general anesthesia (n…
Thrombosis, fracture, and percutaneous removal of a patent foramen ovale closure device 1 month after successful deployment
2010
Several different devices have been developed for the percutaneous closure of interatrial defects and patent foramen ovale. Although the implantation of these devices is both safe and effective, a number of complications, both in the early and the late follow-up, may occur. We describe a case of device fracture manifested early (1 month after implantation) with the formation of massive thrombosis on the right atrial disc. The patient was treated with anticoagulants and the device was percutaneously retrieved. Our images allowed early noninvasive therapy and emphasize the need for echocardiographic follow-up early after implantation. © 2010 Wiley-Liss, Inc.
List of cave‐dwelling (hypogeal) species and subspecies considered as troglobites and stygobias of the Iberian Peninsula and the Balearic Islands
2022
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El virus del Papiloma Humano en cavidad oral y orofaríngea en estudiantes universitarios de 18 a 25 años en Valencia
2017
INTRODUCCIÓN Y JUSTIFICACIÓN DEL ESTUDIO El VPH es una de las infecciones virales más extendidas en la población. Estudios epidemiológicos revelan que la infección oral por VPH juega un papel importante en el desarrollo de enfermedades precancerosas o cánceres de la cavidad oral, en particular en el cáncer de células escamosas orales.1 Aunque se han descrito más de 140 genotipos de VPH, no todos ellos tienen el mismo riesgo de provocar lesiones pre-malignas o cánceres. El genotipo VPH-16 está implicado en la mayoría de estas lesiones, aunque existen otros genotipos carcinogénico. Es una infección indetectable ya que, suele revertir de forma espontánea sin derivar en lesiones premalignas o m…
Endoplasmic reticulum stress is involved in response of human laryngeal carcinoma cells to carboplatin but is absent in carboplatin resistant cells
2013
The major obstacle of successful tumor treatment with carboplatin (CBP) is the development of drug resistance. In the present study, we found that following treatment with CBP the amount of platinum which enters the human laryngeal carcinoma (HEp2)-derived CBP- resistant (7T) cells is reduced relative to the parental HEp2. As a consequence, the formation of reactive oxidative species (ROS) is reduced, the induction of endoplasmic reticulum (ER) stress is diminished, the amount of inter- and intrastrand cross-links is lower, and the induction of apoptosis is depressed. In HEp2 cells, ROS scavenger tempol, inhibitor of ER stress salubrinal, as well as gene silencing of ER stress marker CCAAT/…