Search results for "geste"
showing 10 items of 242 documents
Evaluación del grado de conversión de los receptores HER2, RE y RPg entre el cáncer de mama primario y sus respectivas metástasis
2017
Introducción: Tradicionalmente, las decisiones terapéuticas tanto del cáncer de mama precoz como de los estadios avanzados se han basado en los marcadores predictivos del tumor primario, tales como el receptor de estrógeno (RE), el receptor de progesterona (RPg) y el receptor 2 del factor de crecimiento epidérmico humano (HER2), asumiendo que éstos permanecían inmutables a nivel de la recaída metastásica. Objetivos: El objetivo general de esta tesis era investigar si el estado de los receptores HER2, RE y RPg realmente puede cambiar durante la progresión del cáncer de mama y profundizar en las causas y en el impacto clínico de dichos cambios. El objetivo principal era determinar la tasa de …
A literature review of sensor ontologies for manufacturing applications
2013
The purpose of this paper is to review existing sensor and sensor network ontologies to understand whether they can be reused as a basis for a manufacturing perception sensor ontology, or if the existing ontologies hold lessons for the development of a new ontology. We develop an initial set of requirements that should apply to a manufacturing perception sensor ontology. These initial requirements are used in reviewing selected existing sensor ontologies. Additionally, we present our developed sensor ontology thus far that incorporates a refined list of requirements. This paper describes 1) extending and refining the requirements; 2) proposing hierarchical structures for verifying the purpo…
A Survey on Ontology Evaluation Methods
2015
International audience; Ontologies nowadays have become widely used for knowledge representation, and are considered as foundation for Semantic Web. However with their wide spread usage, a question of their evaluation increased even more. This paper addresses the issue of finding an efficient ontology evaluation method by presenting the existing ontology evaluation techniques, while discussing their advantages and drawbacks. The presented ontology evaluation techniques can be grouped into four categories: gold standard-based, corpus-based, task-based and criteria based approaches.
Ontology Views for Ontology Change Management
2014
International audience; In the literature, ontology change management systems (OCMS) are direct implementation of the concept of “change management” stated by reference (Klein, 2004). Ontology change management combines ontol- ogy evolution and versioning features to manage ontol- ogy changes and their impacts. Since 2007, many works have combined ontology evolution and versioning into ontology change management systems (OCMS). The evolution subject has been massively studied in these works. They especially addressed the consistence issue for the application of changes on the ontology. These proposals constituted a consequent background for ontology change management but they did not take i…
Modeling Changes for SHOIN(D) Ontologies: An Exhaustive Structural Model
2013
Ontology development starts with a rigorous ontological analysis that provides a conceptualization of the domain to model agreed by the community. An ontology, specified in a formal language, approximates the intended models of this conceptualization. It needs then to be revised and refined until an ontological commitment is found. Also ulterior updates, responding to changes in the domain and/or the conceptualization, are expected to occur throughout the ontology life cycle. To handle a consistent application of changes, a couple of ontology evolution methodologies have been proposed. Maintaining the structural consistency is one of the ontology evolution criteria. It implies modeling chan…
Model Driven Specification of Ontology Translations
2008
The alignment of different ontologies requires the specification, representation and execution of translation rules. The rules need to integrate translations at the lexical, the syntactic and the semantic layer requiring semantic reasoning as well as low-level specification of ad-hoc conversions of data. Existing formalisms for representing translation rules cannot cover the representation needs of these three layers in one model. We propose a metamodel-based representation of ontology alignments that integrate semantic translations using description logics and lower level translation specifications into one model of representation for ontology alignments.
Data Mining of Specific-Domain Ontology Components
2008
This paper describes an approach for eliciting ontology components by using knowledge maps. The knowledge contained in a particular domain, any kind of text digital archive, is portrayed by assembling and displaying its ontology components.
Semi-automatic Derivation of Specific-Domain Ontologies for the Semantic Web
2006
This paper describes an approach for helping in the semi-automatic construction of specific-domain ontology components contained in a digital archive. This proposal for extracting knowledge from digital sources allows users to have a view of this knowledge and visualize specific-domain ontology components that with further processing can be shared with software agents by embedding it into digital archives themselves in the context of the Semantic Web. In particular, we deal with the issue of not constructing the ontology from scratch, our approach helps us to speed up the ontology creation process.
Long-term effects of oral and transdermal hormone replacement therapy on plasma homocysteine levels.
2003
Objective To compare the long-term effects of oral and transdermal hormone replacement therapy (HRT) on serum homocysteine levels in postmenopausal women. Design An open, prospective, controlled study. Seventy-five healthy postmenopausal women were recruited as eligible for the study. Fifty women seeking HRT were randomized to receive continuous 17beta-estradiol, either by oral (2 mg daily; n = 25) or transdermal (50 microg daily; n = 25) administration, plus 10 mg dydrogesterone daily for 14 days of each 28-day cycle. Twenty-five women unwilling to receive hormone treatment received only calcium supplementation, representing the control group. Fasting blood samples were analyzed at baselin…
Expresión, localización y estudio funcional de PGRMC1 en el endometrio humano a lo largo del ciclo menstrual
2018
Las acciones de la progesterona (P4), en el sistema reproductivo femenino, están principalmente mediadas por los receptores clásicos de la progesterona (PR), que actúan como factores de transcripción. Sin embargo, no todas las acciones fisiológicas de la progesterona pueden explicarse por la activación de dichos receptores. De hecho, se conoce que la progesterona actúa también a través de vías de señalización no clásica más rápidas, mediadas por la activación de receptores de la membrana celular. Entre los receptores no clásicos de la progesterona encontramos PGRMC1 (Progesterone receptor membrane component 1), cuyo mecanismo de acción queda por ser definido. La interacción P4-PGRMC1 media …