Search results for "geste"

The intermediate role of 18-hydroxycorticosteroids in aldosterone biosynthesis.

1968

Durch ihre Eigenschaft, bestimmte Stufen bei der Bildung radioaktiv markierten Aldosterons aus14C-Progesteron bzw.3H-11-Desoxycorticosteron zu hemmen, erwiesen sich 11-Desoxycorticosteron, Corticosteron und 18-Hydroxycorticosteron als wesentliche Zwischenstufen der Aldosteronbiosynthese. 18-Hydroxy-11-desoxycorticosteron hingegen scheint an der Bildung von Aldosteron nicht beteiligt zu sein.

Biotin-Labelled and Photoactivatable Aldosterone and Progesterone Derivatives as Ligands for Affinity Chromatography, Fluorescence Immunoassays and P…

1996

New derivatives of progesterone and aldosterone were synthesized and functionally tested with commercially available antibodies. The covalent labelling of antibodies specific for aldosterone and progesterone was detected by SDS/PAGE analysis and subsequent autoradiography after using 3-(O-carboxymethyl)-oximino-(3-[125I]iodo-4-azidosalicylamidobu tylamine) derivatives of aldosterone and progesterone, respectively, as photoactivatable radioligands. Labelling was not observed in the presence of an excess of the unlabelled steroid. Aldosterone was labelled with biotin and used as a tracer in a time-resolved fluorescence immunoassay. The nonradioactive tracer is highly selective for its antibod…

Modalità e tipologie dell’epica normanna tra Francia, Inghilterra e Italia meridionale

2017

Attraverso la presentazione e l’analisi – ovviamente parziali e circoscritte ad alcuni passi-campione, opportunamente scelti – di quattro testi variamente afferenti alla produzione epica di età normanna, in volgare e in latino, in Francia (la chanson di «Gormont et Isembart»), Inghilterra (il «Carmen de Hastingae proelio» attribuito a Guy d’Amiens) e Italia meridionale (i «Gesta Roberti Wiscardi» di Guglielmo il Pugliese e il «Liber ad honorem Augusti» di Pietro da Eboli), tra la seconda metà dell’XI secolo e l’ultimo scorcio del XII, si tenta di enucleare alcune delle modalità e delle tipologie distintive di tale produzione epica. Gli elementi costitutivi di tale produzione, a grandi linee…

MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth.

2019

Background Maternal–embryonic crosstalk between the endometrium and the preimplantation embryo is required for normal pregnancy. Our previous results demonstrated that maternal microRNAs secreted into the endometrial fluid, specifically miR-30d, act as a transcriptomic regulator of the preimplantation embryo by the maternal intrauterine environment. Objective To investigate the reproductive and fetal effects of murine miR-30d deficiency at the maternal–embryonic interface according to the origin of its maternal or embryonic default. Study Design A miR-30d knockout murine model was used as the animal model to investigate the impact of maternal and/or embryonic origin of miR-30d deficiency on…

Alteration of poly (ADP-Rib) synthesis during progesterone- caused gene expression in oviducts of quails.

1976

Summary The biological model of the selective induction of RNA synthesis in oviducts of estrogen stimulated immature quails by progesterone has been used to clarify whether poly (ADP-Rib) is involved in DNA transcription. The chromatin-bound as well as the soluble poly (ADP-Rib) polymerase has been isolated from oviducts and the optimal reaction conditions have been determined. The activities, as measured by the incorporation rates of NAD + into poly (ADP-Rib), of both, chromatin-bound « endogenouspolymerase (in the absence of « exogenousDNA and histones) and soluble enzyme (native DNA - lysine-rich histone ratio: 4.3) from progesterone treated quail oviducts, have been determined to be onl…

The implicit in "In search of lost ime"‎ : study on an aspect of proustien speech

2013

The implicit is defined as content present in speech without being formally expressed. Presupposition and implied content are the two fundamental elements of this concept. They act as information implied in speech whose essence the speaker can grasp or decrypt using the theories of pragmatics and enunciative linguistics. Proustian speech constitutes a remarkable example of the use of the implicit and its concepts. The present work is entirely devoted to the search for the implicit in Proust’s In Search of Lost Time. In our work, the development of this concept emerges especially in the verbal interaction between Proust's characters, also, through the speech of the narrator who opts for a ne…

Doubtful association between progesterone therapy and fetal nuchal translucency

2015

Il Progesterone e la minaccia d'aborto: rationale, pratica ed evidenza.

2007

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast can…

2010

Introduction Accumulating evidence suggests that both levels and activity of the estrogen receptor (ER) and the progesterone receptor (PR) are dramatically influenced by growth-factor receptor (GFR) signaling pathways, and that this crosstalk is a major determinant of both breast cancer progression and response to therapy. The phosphatidylinositol 3-kinase (PI3K) pathway, a key mediator of GFR signaling, is one of the most altered pathways in breast cancer. We thus examined whether deregulated PI3K signaling in luminal ER+ breast tumors is associated with ER level and activity and intrinsic molecular subtype. Methods We defined two independent molecular signatures of the PI3K pathway: a pro…

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer

2009

Abstract Purpose: We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling. Experimental Design: The expression levels of cyclins B1, D1, and E1 were quantified in 779 breast tumors and 53 cell lines using reverse phase protein arrays and/or transcriptional profiling. Results: Whereas cyclin E1 overexpression was a specific marker of triple-negative and basal-like tumors, cyclin B1 overexpression occurred in poor prognosis hormone receptor–positive, luminal B and basal-like breast cancers. Cyclin D1 overexpression occurred in lum…