Search results for "ginecologia"

showing 10 items of 340 documents

Out-of-the-box pelvic surgery including iliopsoas resection for recurrent gynecological malignancies: Does that make sense? A single-institution case…

2017

Abstract Objective To report morbidity and oncological outcomes in a consecutive series of lateral isolated recurrent gynecological cancer involving the pelvic side wall (PSW) including the iliopsoas muscle. Material and methods We retrospectively evaluated a consecutive series between 6/2013 and 12/2015 of lateral isolated recurrent gynecological malignancies treated with a lateral endopelvic resection (LEPR). LEPR was defined as an en-bloc lateral resection of a pelvic tumor with sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Post-surgical complications, quality of life (QoL) and survivals were computed. Results Seventy-four women with pelvic isolated r…

Pelvic NeoplasmPsoas MusclePostoperative Complications0302 clinical medicineQuality of lifeRetrospective StudieUterine NeoplasmPelvic Neoplasms030212 general & internal medicineIliopsoas resection; Lateral endopelvic resection; Pelvic side wall disease; Recurrent gynecological malignanciesPelvic NeoplasmsPsoas MusclesOvarian NeoplasmsPelvic side wall diseaseGraft Occlusion VascularPeripheral Nervous System DiseasesIliopsoas resectionGeneral MedicineMiddle AgedThrombosisCompartment SyndromeTreatment OutcomeOncology030220 oncology & carcinogenesisUterine NeoplasmsThrombosiFemaleIliopsoasHumanAdultmedicine.medical_specialtyIliopsoas MuscleIliopsoas resection; Lateral endopelvic resection; Pelvic side wall disease; Recurrent gynecological malignancies; Adult; Aged; Compartment Syndromes; Disease-Free Survival; Female; Graft Occlusion Vascular; Humans; Middle Aged; Muscle Skeletal; Neoplasm Recurrence Local; Ovarian Neoplasms; Pelvic Neoplasms; Peripheral Nervous System Diseases; Postoperative Complications; Psoas Muscles; Quality of Life; Retrospective Studies; Thrombosis; Treatment Outcome; Uterine Neoplasms; Surgery; OncologyCompartment SyndromesDisease-Free Survival03 medical and health sciencesmedicineHumansMuscle SkeletalRetrospective StudiesAgedbusiness.industryOvarian NeoplasmThrombosisRetrospective cohort studyPerioperativeRecurrent gynecological malignanciemedicine.diseaseSurgerySettore MED/40 - GINECOLOGIA E OSTETRICIAQuality of LifeLateral endopelvic resectionPelvic tumorSurgeryPostoperative ComplicationRecurrent gynecological malignanciesNeoplasm Recurrence LocalPeripheral Nervous System DiseasebusinessEuropean Journal of Surgical Oncology (EJSO)
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Pelvic exenteration for recurrent endometrial adenocarcinoma: a retrospective multi-institutional study about 21 patients.

2014

ObjectiveThe aim of our study was to evaluate morbidity, mortality, and long-term survival of patients who underwent pelvic exenteration (PE) with curative intent for recurrence of endometrial adenocarcinoma during a single decade.MethodsWe defined a cohort of 21 patients who met our inclusion criteria, referred to 4 cooperating gynecologic oncology settings in Germany and Italy between 2000 and 2011. Data regarding surgery, histology, and oncologic outcomes were collected and statistically evaluated. Survival was determined from the day of exenteration until the last follow-up or death.ResultsThe median age was 66 years. A total of 42.9% of the patients had major complications, and a compl…

Pelvic Neoplasmmedicine.medical_specialtySurvivalPrognosimedicine.medical_treatmentendometrial adenocarcinomaGynecologic oncologyAdenocarcinomaFollow-Up StudieRetrospective StudiemedicineHumansEndometrial NeoplasmPelvic NeoplasmsSurvival rateAgedNeoplasm StagingPelvic NeoplasmsRetrospective StudiesAged 80 and overPelvic exenteration recurrent endometrial adenocarcinomaPelvic exenterationbusiness.industryMedicine (all)Endometrial cancerGeneral surgeryObstetrics and GynecologyRecurrent endometrial cancerRetrospective cohort studyPerioperativeMiddle Agedmedicine.diseasePrognosisSurgeryEndometrial Neoplasmspelvic exenterationSurvival RateSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologyCohortFemaleMorbidityNeoplasm Recurrence LocalbusinessHumanFollow-Up Studies
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Concurrent Diagnosis of Adenomyosis and Congenital Uterine Anomalies: A Review

2023

Background: Adenomyosis and congenital uterine anomalies (CUAs) can compromise reproductive potential and may coexist in the same patient, especially in cases of infertility. This review (CRD42022382850) aims to evaluate the published cases of concurrent adenomyosis and syndromic and nonsyndromic CUAs. Methods: A literature search for suitable articles published in the English language was performed using the following databases from inception to 30 November 2022: MEDLINE, EMBASE, Global Health, the Cochrane Library, Health Technology Assessment Database, and Web of Science. Articles including both CUAs and adenomyosis, with data about their potential relationship, were included. Results: T…

Pelvic pain.Congenital uterine anomalieMedicine (miscellaneous)AdenomyosiSettore MED/40 - Ginecologia E Ostetricia
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Introduction to the special issue: 2012 AE-PCOS meeting

2013

No abstract available

PharmacologyEndocrinologyOrganic ChemistryClinical BiochemistryPCOS Cardiovascular risk infertility hyperandrogenism insulin resistanceMolecular BiologyBiochemistrySettore MED/40 - Ginecologia E OstetriciaSettore MED/11 - Malattie Dell'Apparato CardiovascolareSettore MED/13 - Endocrinologia
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Editorial

2012

PharmacologyEndocrinologyOrganic ChemistryClinical BiochemistryPCOS Hyperandrogenism Insulin resistanceSettore MED/40 - Ginecologia E OstetriciaMolecular BiologyBiochemistrySettore MED/13 - EndocrinologiaSteroids
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Treating cancer in older and oldest old patients.

2015

The so-called “silver tsunami” is a metaphor that the individuals 65 and older represent the most rapidly growing segment of the Western world population. Aging is an ongoing process that leads to the loss of functional reserve of multiple organ systems, increased susceptibility to stress, it is associated with increased prevalence of chronic disease, and functional dependence. Determined by a combination of genetic and environmental factors, this process is highly individualized and poorly reflected in chronologic age. The heterogeneity and the complexity of the older old population represent the main challenge to the treatment of cancer in those patients. We should discern "fit" elderly i…

PharmacologyGerontologyAged 80 and overeducation.field_of_studybusiness.industryPopulationAge FactorsCancermedicine.diseaseOldest oldolder patientsSettore MED/40 - GINECOLOGIA E OSTETRICIAChronic diseaseSarcopeniaNeoplasmsDrug DiscoverymedicinecancerWestern worldHumansMeaning (existential)educationbusinessOrgan systemCurrent pharmaceutical design
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Inositols in the ovaries: activities and potential therapeutic applications.

2022

Introduction: Myo-inositol (MI) and D-chiro-inositol (DCI) play a key role in ovarian physiology, as they are second messengers of insulin and gonadotropins. Ex-vivo and in-vitro experiments demonstrate that both isomers are deeply involved in steroid biosynthesis, and that reduced MI-to-DCI ratios are associated with pathological imbalance of sex hormones. Areas covered: This expert opinion provides an overview of the physiological distribution of MI and DCI in the ovarian tissues, and a thorough insight of their involvement into ovarian steroidogenesis. Insulin resistance and compensatory hyperinsulinemia dramatically reduce the MI-to-DCI ratio in the ovaries, leading to gynecological dis…

PharmacologyOvarian SteroidogenesiGeneral MedicineToxicologySettore MED/40 - Ginecologia E Ostetriciad-chiro-inositol.EpimeraseSettore BIO/13 - Biologia ApplicataMyo-inositolSettore BIO/14 - FarmacologiaHumansInsulinFemaleInsulin ResistanceGenital Diseases FemaleInositolPolycystic Ovary SyndromeExpert opinion on drug metabolismtoxicology
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A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date

2023

Endometriosis is a chronic gynecologic condition that affects around 6-10% of reproductive age women. This clinical entity is characterized with pelvic pain, dysmenorrhea, dyspareunia, and infertility which are the most often presenting symptoms. Aromatase P450 is the key enzyme for ovarian estrogen biosynthesis and there is evidence that endometriotic lesions express aromatase and are able to synthesize their own estrogens. Aromatase inhibitors (AIs) are potent drugs that suppress the estrogen synthesis via suppression of aromatase. We performed a systematic review of systematic reviews and narrative reviews on the use of aromatase inhibitors in the medical management of endometriosis. We …

PharmacologySystematic review.Pelvic painpresenze.accessorio(at)unipa.itDrug DiscoveryPharmaceutical ScienceEndometriosiAdverse effectSettore MED/40 - Ginecologia E OstetriciaDrug Design, Development and Therapy
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Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled tria…

2023

Objective: Tranexamic acid (TXA) is a cost-effective intervention for the prevention of postpartum hemorrhage (PPH) in women undergoing cesarean section but the evidence to support its use is conflicting. We conducted this meta-analysis to evaluate the efficacy and safety of TXA in low- and high-risk cesarean deliveries. Data sources: We searched MEDLINE (via PubMed), Embase, the Cochrane Library, ClinicalTrials.gov, and WHO International Clinical Trials Registry Platform (ICTRP) portal from inception to April 2022 (updated October 2022 and February 2023) with no language restrictions. Additionally, grey literature sources were also explored. Study eligibility criteria: All randomized contr…

Postpartum hemorrhageAntifibrinolyticMeta-analysiTranexamic acid.Cesarean sectionSettore MED/40 - Ginecologia E Ostetricia
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Postpartum Hemorrhage: Conservative Treatments

2023

Postpartum hemorrhage (PPH) is an obstetric emergency representing the first cause of obstetric mortality and a frequent cause of severe maternal morbidity. It can complicate vaginal or cesarean deliveries and accounts for 25% of all maternal deaths worldwide, as reported by the World Health Organization (WHO). Primary PPH is defined as blood loss from the genital tract of at least 500 ml after vaginal or 1000 ml following cesarean delivery within 24 h postpartum, whereas secondary PPH is defined as any significant bleeding from the birth canal occurring between 24 h and 12 weeks postnatally. Uterine atony is reported as the main cause of PPH and accounts for 75%–90% of primary PPH. When ut…

Postpartum hemorrhageUterotonic agentUterine tamponade procedureVascular ligation.Selective arterial embolizationUterine compression sutureUterine atonySettore MED/40 - Ginecologia E Ostetricia
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