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showing 10 items of 7116 documents

A longitudinal single-center cohort study on the prevalence and risk of accessory saphenous vein reflux after radiofrequency segmental thermal ablati…

2015

Objective Endothermal ablation has become a commonly used technology for occlusion of refluxing great saphenous veins (GSVs). However, the risk for primarily untreated accessory saphenous veins (ASVs) to develop reflux during follow-up has not yet been defined. Here, the prevalence and risk of ASV reflux is explored. Methods During a prospective multicenter cohort study on radiofrequency segmental thermal ablation of refluxing GSVs, the presence and reflux status of ASVs were monitored in 93 legs in a single center. Control examinations were performed after 1 week and at 12, 24, 36, and 48 months. Life-table and multiple regression analyses were used to describe frequency and risk factors f…

AdultMalemedicine.medical_specialtyanimal structuresAdolescentmedicine.medical_treatmentFemoral veinCatheter ablationAnterior accessory saphenous veinVeinsCohort StudiesVaricose VeinsYoung AdultVaricose veinsOcclusionPrevalencemedicineHumansSaphenous VeinLongitudinal StudiesProspective StudiesProspective cohort studyAgedLegbusiness.industryHemodynamicsRefluxFemoral VeinMiddle AgedAblationSurgeryTreatment Outcomemedicine.anatomical_structureVenous Insufficiencyembryonic structuresCatheter AblationFemaleSurgerymedicine.symptomCardiology and Cardiovascular MedicinebusinessJournal of Vascular Surgery: Venous and Lymphatic Disorders
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Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicen…

2019

Abstract Background and Aims Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] and cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characteristics and management of PSC in IBD patients, and the factors associated with malignancies. Methods PSC-IBD patients were identified from the Spanish ENEIDA registry of GETECCU. Additional data were collected using the AEG-REDCap electronic data capture tool. Results In total, 277 PSC-IBD patients were included, with an incidence rate of 61 PSC cases per 100 000 IBD patient-years, 69.7% …

AdultMalemedicine.medical_specialtyendocrine system diseasesColorectal cancerCholangitis SclerosingRisk AssessmentGastroenterologyInflammatory bowel diseasedigestive systemPrimary sclerosing cholangitisCholangiocarcinomaBile Ducts ExtrahepaticRisk FactorsInterquartile rangeinflammatory bowel diseaseInternal medicineHumansMedicineRetrospective Studiesbusiness.industryPrimary sclerosing cholangitisHazard ratiodigestive oral and skin physiologyGastroenterologyRetrospective cohort studyGeneral MedicineOdds ratioMiddle AgedInflammatory Bowel Diseasesmedicine.diseaseSurvival AnalysisUlcerative colitisdigestive system diseasesPatient Care ManagementBile Ducts IntrahepaticSpainFemalePrimary sclerosing cholangitis inflammatory bowel disease malignancyColorectal Neoplasmsbusinessmalignancy
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Diurnal coupling between testosterone and cortisol from adolescence to older adulthood

2016

The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are typically conceptualized as mutually inhibitory systems; however, previous studies have found evidence for positive within-person associations (i.e., coupling) between cortisol and testosterone. One developmental hypothesis is that positive testosterone-cortisol coupling is unique to the adolescent period and that coupling becomes attenuated, or even switches direction, in adulthood. This study used a lifespan sample (N = 292, ages 11 to 88) to test for age-related differences in coupling between cortisol and testosterone in daily life. Participants provided salivary hormone samples at waking, 30 minu…

AdultMalemedicine.medical_specialtyendocrine systemHypothalamo-Hypophyseal SystemEveningAdolescentHydrocortisoneEndocrinology Diabetes and MetabolismPituitary-Adrenal SystemDiurnal changeBiology050105 experimental psychologyArticle03 medical and health sciencesYoung Adult0302 clinical medicineEndocrinologyInternal medicinemedicineHumans0501 psychology and cognitive sciencesTestosteroneLongitudinal StudiesYoung adultChildGonadsSalivaBiological PsychiatryHydrocortisoneAgedAged 80 and overEndocrine and Autonomic Systems05 social sciencesTestosterone (patch)Middle AgedCoupling (electronics)Psychiatry and Mental healthEndocrinologyFemaleDual axis030217 neurology & neurosurgerymedicine.drugHormone
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Assessment of successful valve reconstruction by intraoperative transesophageal echocardiography (TEE)

1986

In 17 patients (10 patients with mitral insufficiency, 5 patients with tricuspid regurgitation, 2 patients with mitral stenosis) the result of valve reconstruction was evaluated by intraoperative two-dimensional transesophageal contrast-echocardiography (TEE). Therefore, 1–2 cc of an agitated contrast-medium (GelifundolR) were injected into the left or right ventricle. The result of reconstruction was assessed by the extent of regurgitant microbubbles into the left or right atrium. A successful valve repair could be demonstrated in 15 patients without or with only minimal regurgitation of contrast-fluid. In one patient residual severe mitral insufficiency after valve reconstruction could on…

AdultMalemedicine.medical_specialtymedicine.medical_treatmentRegurgitation (circulation)Intraoperative PeriodEsophagusValve replacementInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingHeart valveCardiac imagingAgedbusiness.industryMiddle Agedmedicine.diseaseHeart ValvesSurgeryStenosismedicine.anatomical_structureEchocardiographyVentricleMitral incompetencecardiovascular systemCardiologyFemaleIntraoperative PeriodCardiology and Cardiovascular MedicinebusinessThe International Journal of Cardiac Imaging
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Trajectories of Blood Pressure Elevation Preceding Hypertension Onset: An Analysis of the Framingham Heart Study Original Cohort

2018

Importance Given that hypertension remains a leading risk factor for chronic disease globally, there are substantial ongoing efforts to define the optimal range of blood pressure (BP). Objective To identify a common threshold level above which BP rise tends to accelerate in progression toward hypertension. Design, Setting, and Participants This longitudinal, community-based epidemiological cohort study of adults enrolled in Framingham, Massachusetts, included 1252 participants (mean [SD] age, 35.3 [2.7] years) from the Framingham Original Cohort, of whom 790 (63.1%) were women. Each participant contributed up to 28 serial examinations of standardized resting BP measurements between 1948 and…

AdultMalemedicine.medical_specialtysystolic blood pressuresegmented mixed modelHemodynamicsBlood Pressurethreshold value030204 cardiovascular system & hematology03 medical and health sciencesSex Factors0302 clinical medicineFramingham Heart StudyInternal medicineHumansMedicineLongitudinal Studies030212 general & internal medicineAge of OnsetRisk factorAgedAged 80 and overFramingham Risk Scorebusiness.industryBrief ReportAge FactorsMiddle Agedta3121Blood pressureMassachusettsHypertensionCohortDisease ProgressionCardiologyFemaleAge of onsetCardiology and Cardiovascular MedicinebusinessCohort study
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Magnetic resonance myelography evaluation of the lumbar spine end plates and intervertebral disks.

2005

Purpose: To evaluate the value of magnetic resonance (MR) myelography in the evaluation of intervertebral disk and end‐plate degenerative changes in the lumbar spine.Material and Methods: Conventional MR and MR myelography examinations were performed in 150 consecutive patients (69 F and 81 M, mean age 45±15 years, range 18–89). Sagittal T1 and T2‐weighted TSE images were compared to MR myelography obtained with a multishot‐TSE‐T2‐weighted sequence (4000/250/fat suppression). Coronal, sagittal, and both oblique MR myelography projections were obtained. Image analysis was carried out independently by two radiologists who categorized lumbar disks into normal, degenerated, or edematous; and ve…

AdultMalemusculoskeletal diseasesAdolescent030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineDegenerative diseaseLumbarMedicineHumansRadiology Nuclear Medicine and imagingGrowth PlateProspective StudiesIntervertebral Discskin and connective tissue diseasesMyelographyAgedAged 80 and overLumbar VertebraeRadiological and Ultrasound Technologymedicine.diagnostic_testbusiness.industryReproducibility of ResultsMagnetic resonance imagingGeneral MedicineMiddle Agedmedicine.diseaseequipment and suppliesMagnetic Resonance ImagingSagittal planeIntervertebral diskmedicine.anatomical_structure030220 oncology & carcinogenesisCoronal planeLumbar spineFemaleSpinal Diseasessense organsbusinessNuclear medicineMyelographyLow Back Painhuman activities
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Effects of barbell back squat stance width on sagittal and frontal hip and knee kinetics

2018

Different stance widths are commonly utilized when completing the barbell back squat during athletic general preparedness training. Width manipulation is thought to influence sagittal plane stimuli to the hip and knee extensors, the primary extensor musculature in the squat. However, how width manipulation affects frontal plane stimuli is less understood. Knowledge of hip and knee net joint moments (NJM) could improve exercise selection when aiming to improve sport-specific performance and prevent injuries. Fourteen adult amateur rugby athletes were recruited for this study. After a familiarization period, participants performed wide- (WIDE, 1.5× greater trochanter width) and narrow-stance …

AdultMalemusculoskeletal diseasesGreater trochanterStrength trainingPosturePhysical Therapy Sports Therapy and RehabilitationSquatKinematics030204 cardiovascular system & hematologyWeight-BearingYoung Adult03 medical and health scienceschange of direction0302 clinical medicinestrength trainingHumansMedicineKneeOrthopedics and Sports MedicineFemurRange of Motion ArticularMuscle Skeletalta315kiihtyvyysdynamiikkaOrthodonticsHipliikeoppiKnee extensorsbusiness.industryacceleration030229 sport sciencesmusculoskeletal systemSagittal planeBiomechanical PhenomenaCross-Sectional Studiesmedicine.anatomical_structureAthleteskineticskinematicsCoronal planeFemalevoimaharjoittelubiomekaniikkabusinesshuman activitiesScandinavian Journal of Medicine & Science in Sports
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Fatal hypersensitivity reaction to an oral spray of flurbiprofen: a case report

2013

Summary What is known and objective Safety of the anti-inflammatory drug flurbiprofen is comparable with that of other non-steroidal anti-inflammatory drugs of the propionic acid class, which are commonly associated with gastrointestinal and renal side effects. Here we report a case of a fatal hypersensitivity reaction to an oral spray of flurbiprofen taken for sore throat. Case summary A 29-year-old man came to the emergency care unit reporting sore throat with an intense burning sensation associated with fever. Pharyngotonsillitis was diagnosed, and local treatment with oral flurbiprofen spray was prescribed. Immediately after using the spray, the patient experienced a severe reaction cha…

AdultMaleoral sprayAllergyAdministration TopicalFlurbiprofenAdministration OralFatal hypersensitivity reaction; oral spray; flurbiprofenadverse Effect; adverse reaction; anti inflammatory; fatal reaction; flurbiprofen; hypersensitivity; NSAID; pharmacovigilance; sprayDrug HypersensitivitySettore MED/43 - Medicina LegalemedicineMaculopapular rashSore throatHumansPharmacology (medical)Fatal hypersensitivity reactionCause of deathPharmacologyAsphyxiabusiness.industryAnti-Inflammatory Agents Non-SteroidalPharyngitismusculoskeletal systemmedicine.diseaseflurbiprofenHypersensitivity reactionAnesthesiaItchinglipids (amino acids peptides and proteins)Oral Spraysmedicine.symptombusinessmedicine.drugJournal of Clinical Pharmacy and Therapeutics
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Motor Development and Physical Activity: A Longitudinal Discordant Twin-Pair Study.

2015

ntroduction : Previous longitudinal research suggests that motor proficiency in early life predicts physical activity in adulthood. Familial effects including genetic and environmental factors could explain the association, but no long-term follow-up studies have taken into account potential confounding by genetic and social family background. The present twin study investigated whether childhood motor skill development is associated with leisure-time physical activity levels in adulthood independent of family background. Methods : Altogether, 1550 twin pairs from the FinnTwin12 study and 1752 twin pairs from the FinnTwin16 study were included in the analysis. Childhood motor development wa…

AdultMalephysical activityPhysical Therapy Sports Therapy and RehabilitationMotor ActivityArticleDevelopmental psychology03 medical and health sciences0302 clinical medicineChild DevelopmentLeisure ActivitiesLinear regressionTwins DizygoticHumansOrthopedics and Sports Medicine030212 general & internal medicineLongitudinal StudiesYoung adultta315ChildMotor skillDiscordant Twinexercisemotor skillsConfoundingta3141twins030229 sport sciencesTwins MonozygoticTwin studyChild developmentPhysical activity levelkaksosetMotor SkillsadolescenceFemalePsychologyMedicine and science in sports and exercise
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Key issues in decomposing fMRI during naturalistic and continuous music experience with independent component analysis

2014

Background: Independent component analysis (ICA) has been often used to decompose fMRI data mostly for the resting-state, block and event-related designs due to its outstanding advantage. For fMRI data during free-listening experiences, only a few exploratory studies applied ICA.New method: For processing the fMRI data elicited by 512-s modern tango, a FFT based band-pass filter was used to further pre-process the fMRI data to remove sources of no interest and noise. Then, a fast model order selection method was applied to estimate the number of sources. Next, both individual ICA and group ICA were performed. Subsequently, ICA components whose temporal courses were significantly correlated …

AdultMalereal-world experiencesComputer scienceSpeech recognitionFast Fourier transformDiffusion mapTIME-SERIESfast model order selectionORDER SELECTION050105 experimental psychologyYoung AdultNUMBER03 medical and health sciences0302 clinical medicineImage Processing Computer-AssistedDiffusion mapHumans0501 psychology and cognitive sciencesICABlock (data storage)ta113Brain MappingPrincipal Component AnalysisGeneral NeurosciencefMRI05 social sciencesBrainFilter (signal processing)Magnetic Resonance ImagingIndependent component analysisSpectral clusteringOxygenMODELDIFFUSION MAPSAcoustic StimulationFFT filterta6131Auditory PerceptionFemaleHUMAN BRAIN ACTIVITYNoise (video)DYNAMICAL-SYSTEMSDigital filterMusic030217 neurology & neurosurgeryMRIJournal of Neuroscience Methods
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