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Uz blokķēdes bāzētie Latvijas augstskolu absolventu diplomi
2018
Darba mērķis ir izveidot sistēmu ar kuras palīdzību varētu izsniegt un glabāt diplomus priekš Latvijas augstskolu absolventiem. Darba ietvaros tika veikta blokķēdes tehnoloģijas pamata darbības principu analīze, kā arī dažādu blokķēžu platformu pētījums. Iegūtās informācijas rezultātā tika izsecināta blokķēdes pielietošanas iespējamība, augstākminētās sistēmas veidošanai. Ir izpētīta digitālā identitāte, kā daļa no paredzētās sistēmas, un tās implementācija uz blokķēdes. Darba noslēgumā ir piedāvāts iespējamais risinājums un turpmākie izaicinājumi, kurus iespējams pētīt tālāk.
Antiidiotypic DNA vaccination induces serum bactericidal activity and protection against group B meningococci
2006
No vaccine is available for preventing infections by serogroup B Neisseria meningitidis (MenB), which accounts for a major portion of meningococcal cases in developed countries, because of the poor immunogenicity of the capsular polysaccharide (CP) even after protein conjugation. We have previously induced anticapsular antibodies by immunization with a single chain variable fragment (scFv), which mimics a protective CP epitope. This surrogate antigen, however, was ineffective at inducing serum bactericidal activity, an accepted marker of protection in humans. Serum bactericidal activity was consistently achieved by immunizing mice with the scFv-encoding gene. Immunization with vectors witho…
Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDI…
2016
Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) f…
Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children
2018
BACKGROUND There are few prospective studies on the associations of changes in objectively measured vigorous physical activity (VPA∆ ), moderate-to-vigorous physical activity (MVPA∆ ), light physical activity (LPA∆ ), and sedentary time (ST∆ ) with changes in cardiometabolic risk factors (∆ ) in children. We therefore investigated these relationships among children. METHODS The participants were a population sample of 258 children aged 6-8 years followed for 2 years. We assessed PA and ST by a combined heart rate and movement sensor; computed continuous age- and sex-adjusted z-scores for waist circumference, blood pressure, and fasting insulin, glucose, triglycerides, and high-density lipop…
Physical Inactivity from Youth to Adulthood and Risk of Impaired Glucose Metabolism
2018
Introduction: Physical activity (PA) is important in the prevention and treatment of impaired glucose metabolism. However, association of physical inactivity during the transition between childhood and adulthood with glucose metabolism is unknown. Therefore, we studied the association of persistent physical inactivity since childhood with glucose metabolism in adulthood. Methods: Data were drawn from the ongoing, Cardiovascular Risk in Young Finns Study with repeated follow-ups between 1980 and 2011 (baseline age, 3-18 yr; n = 3596). Impaired glucose metabolism was defined as having impaired fasting glucose (6.1-6.9 mmol·L-1) or type 2 diabetes in adulthood. Leisure-time PA habits were repe…
The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood
2019
Aims: We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods: This longitudinal birth cohort study (Helsinki Birth Cohort Study) included 1,440 non-diabetic subjects examined at a mean age of 62 years. Subjects were divided into quartiles according to maternal body mass index (BMI). The impact of maternal BMI on offspring body composition was also studied. Results: There were no differences in fasting glucose between the groups. In men, maternal BMI was inversely associated with mean 2-hour glucose concentration after a 75 g oral glucose tolerance test (p <0.…
Branched-Chain and Aromatic Amino Acids Are Associated With Insulin Resistance During Pubertal Development in Girls.
2018
Cross-sectional studies in children show branched-chain and aromatic amino acids are associated with insulin resistance, but whether these associations persist from childhood to adulthood is not known. This study aimed to assess whether circulating amino acids associate with insulin resistance during pubertal development.This was a 7.5-year longitudinal study from childhood to early adulthood. A total of 396 nondiabetic Finnish girls aged 11.2 ± .8 years at baseline participated in the study which was conducted at the Health Science Laboratory, University of Jyväskylä. Serum concentrations of glucose and insulin were determined by enzymatic photometric methods and amino acids by nuclear mag…
Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment.
2001
BACKGROUND:Amyloid precursor protein (APP) forms with apparent molecular weights of 130, 110, and 106 kd are present in human platelets. It has been demonstrated that Alzheimer disease (AD) is specifically associated with a decreased APP forms ratio in platelets. OBJECTIVE:To investigate whether acetylcholinesterase (AChE) inhibitor treatment modifies the ratio of platelet APP forms in patients with AD. PATIENTS AND METHODS:From a large sample of patients with probable AD, 30 with mild to moderate AD were selected. Each patient underwent a clinical evaluation including the Mini-Mental State Examination (MMSE) and platelet APP forms analysis at baseline and after 30 days. During this interva…
Coeval high-pressure metamorphism, thrusting, strike-slip, and extensional shearing in the Tauern Window, Eastern Alps
2008
[1] Recent findings for a young (31.5 ± 0.7 Ma) age of high-pressure metamorphism at ∼90 km depths in the Eclogite Zone of the Tauern Window, Eastern Alps, prompt the question about the timing of the structural development of the Tauern Window and its relation to high-pressure metamorphism. We show that all major structures in the Tauern Window, resulting from strong N-S lithospheric shortening and simultaneous minor E-W extension, began developing coevally with high-pressure metamorphism in the Eclogite Zone. Large-scale strike-slip shear zones started to form at ∼32–30 Ma and facilitated the spatial accommodation of simultaneous shortening and extension. At least some of the strike-slip a…
METAMORPHIC EVOLUTION OF SPESSARTINE QUARTZITES (COTICULES) IN THE HIGH-PRESSURE, LOW-TEMPERATURE COMPLEX AT BAHIA MANSA, COASTAL CORDILLERA OF SOUTH…
2001
Lenses of spessartine quartzites (coticules) are associated with greenschist intercalations in coastal exposures at Bahia Mansa within the mainly metapsammopelitic Western Series, which forms most of the basement in the Coastal Cordillera of central to southern Chile. The chemical compositions of the coticules can be explained by protoliths formed from ferriferous and manganiferous hydrothermal precipitates mixed with aluminous alteration-derived material on top of oceanic crust. The peak conditions of metamorphism were calculated with multivariant reactions: 270–370 °C, 6–8 kbar. A retrograde P–T evolution was marked by decompression to 2 kbar during cooling below 300°C, influx of an exter…