Search results for "gliomas"
showing 3 items of 13 documents
Hydroquinone derivatives from the marine-derived fungus Gliomastix sp.
2017
Eight new hydroquinone derivatives, gliomastins A–D (1–4), 9-O-methylgliomastin C (5), acremonin A 1-O-β-D-glucopyranoside (6), gliomastin E 1-O-β-D-glucopyranoside (7), and 6′-O-acetyl-isohomoarbutin (8), together with seven known analogues were isolated from the marine-derived fungus Gliomastix sp. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR measurements aided by DFT NMR calculations as well as MS data. TDDFT-ECD and OR calculations were performed to determine the absolute configurations of 1 and the aglycones of 6 and 7. Compound 1 features a novel skeleton, biogenetically derived from a Diels–Alder reaction between derivatives of 11 and 1…
Perfiles metabólicos in vivo y ex vivo: apoyo al diagnóstico y manejo clínico de gliomas
2017
UNIVERSITAT DE VALENCIA Facultat de Medicina i Odontología Departament de Cirurgia Programa de Doctorado 3042 - MEDICINA - 444 Tumores cerebrales: estudio genético e inmunohistoquímico PERFILES METABÓLICOS IN VIVO Y EX VIVO: APOYO AL DIAGNOSTICO Y MANEJO CLÍNICO DE GLIOMAS D. Vicente Rovira Lillo Directores: Dr. D. Guillermo García March Dr. D. Bernardo Celda Muñoz Dr. D. José Piquer Belloch Valencia, 2017 INTRODUCCIÓN Los astrocitomas de alto grado son los tumores cerebrales primarios más frecuentes del adulto. El análisis histológico, además de proporcionar información sobre el pronóstico, nos acerca con seguridad al diagnóstico, y es condición indispensable para acceder al tratamiento qu…
Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature
2017
Background: The importance of a complete resection of high-grade gliomas (HGGs) has been highlighted in scientific literature, in order to limit tumor recurrence and above all to improve disease-free survival rates. Several fluorescent biomarkers have been tested to improve intraoperative identification of residual tumor; 5-aminolevulinic acid (5-ALA) and fluorescein sodium (FS) are now starting to play a central role in glioma surgery. We performed a retrospective analysis on 47 patients operated for HGGs. Here we report our preliminary data. Methods: Data of 47 consecutive patients with HGG have been collected in our study (25 males, 22 females; mean age: 60.3 years, range: 27-86 years). …