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Does sex hormone-binding globulin cause insulin resistance during pubertal growth?

2019

Background The directional influences between serum sex hormone-binding globulin (SHBG), adiposity and insulin resistance during pubertal growth remain unclear. The aim of this study was to investigate bidirectional associations between SHBG and insulin resistance (HOMA-IR) and adiposity from childhood to early adulthood. Methods Participants were 396 healthy girls measured at baseline (age 11.2 years) and at 1, 2, 4 and 7.5 years. Serum concentrations of estradiol, testosterone and SHBG were determined by ELISA, glucose and insulin by enzymatic photometry, insulin-like growth factor 1 (IGF-1) by time-resolved fluoroimmunoassays, whole-body fat mass by dual-energy X-ray absorptiometry and …

0301 basic medicinemedicine.medical_specialtypubertyGlobulinEndocrinology Diabetes and Metabolismmedicine.medical_treatment030209 endocrinology & metabolismlcsh:Diseases of the endocrine glands. Clinical endocrinology03 medical and health sciences0302 clinical medicineEndocrinologyInsulin resistanceSex hormone-binding globulinInternal medicineinsulin resistanceInternal Medicinemedicinesex hormone-binding globulinkehonkoostumussukupuolihormonitadipositylcsh:RC648-665biologybusiness.industryResearchInsulinmenarcheConfoundinginsuliiniresistenssimurrosikämedicine.diseasetytöt030104 developmental biologyEndocrinologyglobuliinitHomeostatic model assessmentMenarchebiology.proteinbusinesshormones hormone substitutes and hormone antagonistsEarly pubertyEndocrine Connections
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