Search results for "gon"
showing 10 items of 6445 documents
Gene expression in TGFbeta-induced epithelial cell differentiation in a three-dimensional intestinal epithelial cell differentiation model
2006
Abstract Background The TGFβ1-induced signal transduction processes involved in growth and differentiation are only partly known. The three-dimensional epithelial differentiation model, in which T84 epithelial cells are induced to differentiate either with TGFβ1 or IMR-90 mesenchymal cell-secreted soluble factors, is previously shown to model epithelial cell differentiation seen in intestine. That model has not been used for large scale gene expression studies, such as microarray method. Therefore the gene expression changes were studied in undifferentiated and differentiated three-dimensional T84 cultures with cDNA microarray method in order to study the molecular changes and find new play…
Oligonucleotides-decorated-poly(N-vinyl pyrrolidone) nanogels for gene delivery
2013
Pulsed electron-beam irradiation of a semi-dilute poly(N-vinyl pyrrolidone) (PVP) aqueous solution in the presence of acrylic acid has led to a carboxyl functionalized nanogel system. Nanoparticles hydrodynamic size and surface charge density, in water and as a function of pH, were investigated by dynamic light scattering and laser doppler velocimetry, respectively. Nanogels (NGs) were proved not to be cytotoxic at the cellular level. Indeed, they rapidly bypass the cellular membrane to accumulate in specific cell portions of the cytoplasm, in the perinuclear area. The availability of pendant carboxyl groups on the crosslinked PVP NGs core prompted us to attempt their decoration with a sing…
Absolute kinematics of radio source components in the complete S5 polar cap sample
2008
We report on the first wide-field, high-precision astrometric analysis of the 13 extragalactic radio sources of the complete S5 polar cap sample at 15.4 GHz. We describe new algorithms developed to enable the use of differenced phase delays in wide-field astrometric observations and discuss the impact of using differenced phase delays on the precision of the wide-field astrometric analysis. From this global fit, we obtained estimates of the relative source positions with precisions ranging from 14 to 200 μas at 15.4 GHz, depending on the angular separation of the sources (from ∼1.6 to ∼20.8 degrees). These precisions are ∼10 times higher than the achievable precisions using the phase-refere…
Logarithmic mean inequality for generalized trigonometric and hyperbolic functions
2015
In this paper we study the convexity and concavity properties of generalized trigonometric and hyperbolic functions in case of Logarithmic mean. peerReviewed
Video display terminal use and dry eye: preventive measures and future perspectives
2022
Background: Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry eye disease (DED) stems from a loss-of-tear film homeostasis and is frequently seen in video display terminal (VDT) users. Video display terminal (VDT) use reduces blink rates and increases incomplete blinks, leading to tear film instability and ocular inflammation, promoting DED. Purpose: To assess and evaluate the methods for preventing VDT-associated DED and ocular discomfort. Methods: Studies were found using PubMed and Embase with the search terms: (digital visual terminal* OR computer use OR screen use OR smartphone OR display OR visual display terminal* OR computer vision syndrome OR tablet OR phon…
Temporal resolution and temporal transfer properties: gabaergic and cholinergic mechanisms.
2007
Temporal resolution is a basic property of the visual system and critically depends upon retinal temporal coding properties which are also of importance for directional coding. Whether the temporal coding properties for directional coding derive form inherent properties or critically depend upon the temporal coding mechanisms is unclear. Here, the influence of acetylcholine and GABA upon photopic temporal coding was investigated in goldfish, using flicker stimuli, in a behavioral and an electrophysiological (ERG) approach. The goldfish temporal resolution ability decreased from more than 90% correct choices at 20 Hz flicker frequency to about 65% at 45 Hz flicker frequency with a flicker fu…
Coloration reflects behavioural types in the convict cichlid, Amatitlania siquia.
2015
9 pages; International audience; Interindividual behavioural differences, consistent over time and across situations, are frequently related to differences in reproductive success, susceptibility to disease and competitive ability. The behavioural phenotype of a conspecific is likely to affect the outcome of a social interaction, so an individual must be able to accurately assess behavioural phenotypes in order to optimize behavioural responses during mate choice, cooperative relationships and agonistic interactions. However, behavioural assessment based on dyadic interactions in different contexts can be costly because it may require significant time, increase the risk of predation and oft…
Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample.
2015
Harm avoidance is a personality trait characterized by excessive worrying and fear of uncertainty, which has repeatedly been related to anxiety disorders. Converging lines of research in rodents and humans point towards an involvement of the nicotinic cholinergic system in the modulation of anxiety. Most notably, the rs1044396 polymorphism in the CHRNA4 gene, which codes for the α4 subunit of the nicotinic acetylcholine receptor, has been linked to negative emotionality traits including harm avoidance in a recent study. Against this background, we investigated the association between harm avoidance and the rs1044396 polymorphism using data from N=1673 healthy subjects, which were collected …
Znaczenie prenatalnego okresu życia dla rozwoju tożsamości płciowej
2022
Płeć możemy różnicować na podstawie płci genetycznej, gonadalnej, genitalnej i hormonalnej, odmiennych zachowań kobiety i mężczyzny, różnic w budowie ciała oraz narządów płciowych, tego, czy dany osobnik czuje się kobietą czy mężczyzną. Niniejszy artykuł jest jedynie próbą spojrzenia na płeć ludzką z kilku perspektyw. Próbą pokazania kształtowania się płci oraz czynników, które mogą zaburzyć ten proces.
Tectonic significance of the Variscan suture between Brunovistulia and the Bohemian Massif
2021
The Velke Vrbno Dome crops out at the boundary between the Brunovistulian Terrane and the internal parts of the Bohemian Massif. Here, eclogite boudins occur within an Ediacaran volcano-sedimentary sequence. Strong Nb depletion (Nb/Nb* = 0.19–0.82) combined with moderately positive Nd isotopic compositions (eNd(i) = +3.89 – +5.77) is used to argue for emplacement of the eclogite protoliths in a transitional supra-subduction to continental-rift setting. Conversely, heterogeneously enriched large ion lithophile elements and highly radiogenic Sr isotopic ratios (87Sr/86Sr = 0.705–0.720) are interpreted to have been modified following fluid infiltration subsequent to eclogite-facies metamorphis…