Search results for "gon"
showing 10 items of 6445 documents
Metateoretyczne uwagi do koncepcji polityczności Chantal Mouffe w kontekście jej ideologicznych uwikłań
2017
The article contains the thesis that in political science theories a scientific, ideological and philosophical components are so fused that it is impossible to separate them completely. For this reason, the ideological content not only does not undermine the cognitive value of theoretical argument, but even contributes to it — if the relevant criteria are metI think, that the metatheoretical optics is the most appropriate approach to analyse these criteria. It allows not only to describe given theory, but also enables more problematic deconstruction of its conditions and cognitive status. In this article the analysis of this type is presented on the example of Chantal Mouffe’s agonistic co…
The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guideline…
2010
Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's and Colitis Organisation have published exhaustive Inflammatory Bowel Disease guidelines, national guidelines may be necessary as cultural values, economical and legal issues may differ between countries. For these reasons the Italian Society of Gastroenterology and the Italian Group for the study of Inflammatory Bowel Disease have decided to elaborate the Italian guidelines on the use of biologics in Inflammatory…
Differential of metric valued Sobolev maps
2020
We introduce a notion of differential of a Sobolev map between metric spaces. The differential is given in the framework of tangent and cotangent modules of metric measure spaces, developed by the first author. We prove that our notion is consistent with Kirchheim's metric differential when the source is a Euclidean space, and with the abstract differential provided by the first author when the target is $\mathbb{R}$.
Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.
2015
The immunostimulatory ability of synthetic oligonucleotides containing CpG motifs (CpG-ODN), agonists of Toll-like receptor 9 (TLR9), can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, particularly in the lung, tumor-associated immunosuppression can subvert such antitumor innate immune responses. To locally maintain continuous activation of innate subpopulations while inhibiting immunosuppressive cells, we evaluated aerosol delivery CpG-ODN combined with Poly(I:C), a TLR3 agonist able to convert tumor-supporting macrophages to tumoricidal effectors, in the treatment of B16 melanoma lung metastases …
Variation in developmental mode and its effects on divergence and maintenance of populations
2012
Estudio de la acción proinflamatoria de Angiotensina II y su posible modulación. Papel de Angiotensina II en disfunciones endoteliales.
2002
La acumulación leucocitaria es una característica de los primeros estadios de la lesión aterosclerótica, de infarto agudo de miocardio y de enfermedades renales de diversa etiología. Receptores para Angiotensina-II (Ang-II) han sido hallados en monocitos y Ang-II puede promover la activación y adhesión de estas células. Este proceso podría desencadenar o perpetuar el daño endotelial asociado a aterosclerosis e hipertensión. Los resultados de nuestro estudio demuestran que Ang-II, a dosis subvasoconstrictoras y fisiológicas, presenta propiedades proinflamatorias in vivo a nivel agudo; en concreto, produce acumulación leucocitaria en vénulas de la microcirculación mesentérica de la rata a tra…
Vídeos Facilitación neuromuscular propioceptiva: diagonal miembro superior flexión-aducción-rotación externa / extensión-abducción-rotación interna
2021
Vídeos Facilitación neuromuscular propioceptiva: diagonal miembro superior flexión-aducción-rotación externa / extensión-abducción-rotación interna
Vídeos Facilitación neuromuscular propioceptiva: diagonal miembro superior flexión-abducción-rotación externa / extensión-aducción-rotación interna
2021
Vídeos Facilitación neuromuscular propioceptiva: diagonal miembro superior flexión-abducción-rotación externa / extensión-aducción-rotación interna
Revisiting the disappearance of terrestrial dissolved organic matter in the ocean: A δ13C study
2014
Abstract. Organic carbon (OC) depleted in 13 C is a widely used tracer for terrestrial organic matter (OM) in aquatic sys- tems. Photochemical reactions can, however, change δ 13 C of dissolved organic carbon (DOC) when chromophoric, aromatic-rich terrestrial OC is selectively mineralized. We assessed the robustness of the δ 13 C signature of DOC ( δ 13 C DOC ) as a tracer for terrestrial OM by estimating its change during the photobleaching of chromophoric DOM (CDOM) from 10 large rivers. These rivers cumulatively ac- count for approximately one-third of the world’s freshwater discharge to the global ocean. Photobleaching of CDOM by simulated solar radiation was associated with the photoch…
Proof of Concept of Therapeutic Gene Modulation of MBNL1/2 in Myotonic Dystrophy
2022
La distrofia miotónica tipo 1 es una enfermedad genética rara multisistémica que afecta a 1 de cada 3000-8000 personas. La causa molecular de la enfermedad proviene de repeticiones tóxicas “CTG” en el gen DMPK (DM Protein Kinase). Tras la transcripción, estas repeticiones forman una estructura de horquilla que se une con alta afinidad a la familia de proteínas MBNL (Muscleblind-like) que agota su función de regulación de la poliadenilación y el splicing alternativo postranscripcional en numerosos transcritos. La pérdida de función de MBNL provoca una cascada de efectos posteriores, que eventualmente conducen a síntomas clínicos que incluyen miotonía, debilidad y atrofia muscular, cataratas,…