Search results for "good"
showing 10 items of 5625 documents
TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia
2019
International audience; Targeting TRAIL (Tumor necrosis factor (TNF)-Related Apoptosis-Inducing Ligand) receptors for cancer therapy remains challenging due to tumor cell resistance and poor preparations of TRAIL or its derivatives. Herein, to optimize its therapeutic use, TRAIL was grafted onto iron oxide nanoclusters (NCs) with the aim of increasing its pro-apoptotic potential through nanoparticle-mediated magnetic hyperthermia (MHT) or photothermia (PT). Methods: The nanovector, NC@TRAIL, was characterized in terms of size, grafting efficiency, and potential for MHT and PT. The therapeutic function was assessed on a TRAIL-resistant breast cancer cell line, MDA-MB-231, wild type (WT) or T…
Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets
2020
Modern lifestyle, excessive chemicalization of agricultural products, excessive processing and refining of food, cause a decrease in daily intake of magnesium, cation with an extremely important role in prevention and treatment of many diseases. As a result, there arises the need for extra magnesium intake in the form of dietary supplements. In this study were evaluated the physical and chemical stability of magnesium-containing tablets, depending on the active compound and the excipients used. Magnesium tablets in the form of orotate, lactate, citrate, oxide and hydroxide were taken into study and physical and chemical stability were observed over the validity period, at 6 and at 12 month…
Les ateliers de cuisine : un outil thérapeutique pour le soin et le plaisir des patients
2018
International audience; Les patients atteints d’un cancer se retrouvent souvent confrontés à un ensemble de problématiques les conduisant à opérer des modifications dans leurs pratiques alimentaires. Cet article présente un dispositif d’ateliers culinaires1 à destination des patientes atteintes d’un cancer ainsi que son évaluation tendant à montrer qu’il s’agit d’un outil thérapeutique aidant les patients à mieux prendre en charge leur alimentation. Deux paramètres seront plus spécifiquement étudiés : la déconstruction des idées reçues autour de l’alimentation et l’animation pluridisciplinaire avec la présence d’un chef de cuisine. L’exploration de ces deux points permet d’illustrer que les…
Targeted Drug Delivery in Plants: Enzyme‐Responsive Lignin Nanocarriers for the Curative Treatment of the Worldwide Grapevine Trunk Disease Esca
2019
Abstract Nanocarrier (NC)‐mediated drug delivery is widely researched in medicine but to date has not been used in agriculture. The first curative NC‐based treatment of the worldwide occurring grapevine trunk disease Esca, with more than 2 billion infected plants causing a loss yearly of $1.5 billion, is presented. To date, only repetitive spraying of fungicides is used to reduce chances of infection. This long‐term treatment against Esca uses minimal amounts of fungicide encapsulated in biobased and biodegradable lignin NCs. A single trunk injection of <10 mg fungicide results in curing of an infected plant. Only upon Esca infection, ligninolytic enzymes, secreted by the Esca‐associated fu…
Additional file 6: of Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BR…
2016
Pathology of invasive MBCs in the general population from SEER and BRCA1 MBCs and ORs in predicting male BRCA1 mutation carrier status. (DOCX 19 kb)
Additional file 6: of Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BR…
2016
Pathology of invasive MBCs in the general population from SEER and BRCA1 MBCs and ORs in predicting male BRCA1 mutation carrier status. (DOCX 19 kb)
Las políticas públicas simbólicas para el buen gobierno y la calidad democrática en la Comunitat Valenciana
2017
International audience; Aproved the Law 19/2013 about transparency, access to public information and good governance, public sub-state administrations have had to implement a series of public policies to improve aspects such as the quality of democracy, fighting corruption and reliable information, among others.This paper explores and describes the first steps of Generalitat Valenciana for ensuring transparency and good governance in its territory. Especially, it focuses in the study of the Code of Good Governance. For its purpose, we are going to use a Neoinstitutionalist approach; Con la aprobación de la Ley 19/2013, de transparencia, acceso a la información pública y buen gobierno, las A…
A joint reading of positional and relational goods
2013
Both relational and positional goods are based upon an idea of joint consumption - though with opposite signs. Indeed, in both cases, individuals' consumption choices take into account not only the individuals themselves, but others, as well. Given that relational goods provide a form of identity to their consumers, we show that a certain degree of positionality emerges within the consumption of relational goods. Analogously, except in a two-agent context, each positional good also has a relational component. What emerges is a complex structure of economic outcomes based on both relational and positional motives.
The pentafluorophenyl group as π-acceptor for anions: a case study
2015
Chemical science 6(1), 354-359 (2015). doi:10.1039/C4SC02762K
Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1
2008
The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest in the pharmacological management of preterm labor. Although there is evidence implicating ADRB receptors in the control of inflammation, there are minimal data relating specifically to ADRB3. To explore the cellular consequences of chorioamnionitis and detect apoptosis, we first performed immunostaining and Western blot experiments on human myometrial samples obtained from women with confirmed chorioamnionitis. We then developed an in vitro model of chorioamnionitis by i…