Search results for "grave"
showing 10 items of 236 documents
Radiotherapy for Graves’ ophthalmopathy
2000
The interest in the treatment of benign diseases with radiation therapy has grown particularly in the Western part of the world. In 1996, a questionnaire was sent to 1348 institutes worldwide listed in the directory of the Society for Therapeutic Radiology and Oncology asking whether the respondents considered a list of 28 most common benign disorders as being a good indication for orbital radiotherapy.1 Questions concerned the frequency of such treatments and the treatment schedules used. The prevention of keloid formation was the most widely accepted indication, followed by Graves’ ophthalmopathy. Thus, radiotherapy for this orbital disorder is generally accepted and applied worldwide.
Synchronous Antithyroid Drug-Induced Agranulocytosis and Fournier Gangrene
2018
ABSTRACT: Objective: Antithyroid drugs (ATDs) such as thioimidazoles (e.g., methimazole, also called thiamazole, and carbimazole) and propylthiouracil are commonly used for the treatment of hyperthyroidism. A life-threatening reaction is agranulocytosis with an incidence of 0.1 to 0.5%. There are very few cases in the literature showing that the intake of ATDs finally led to sepsis with accompanying tissue necrosis.Methods: We present an unusual case of severe symptomatic agranulocytosis with sudden development of Fournier gangrene in a patient who was treated with ATDs for hyperthyroidism due to Graves disease.Results: A 69-year-old female was referred to our hospital with fever and a sore…
The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
2019
Highlights • Total thyroidectomy is a safe and effective treatment for Graves’ disease. • It is associated with a very low incidence rate of post-operative complications. • Total thyroidectomy offers a rapid and definitive control of hyperthyroidism and its related symptoms.
Thyrotropin Receptor Blocking Antibodies.
2018
AbstractAutoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) may mimic or block the action of TSH or be functionally neutral. Measurement of anti-TSHR-Ab can be done either via competitive-binding immunoassays or with functional cell-based bioassays. Antibody-binding assays do not assess anti-TSHR-Ab functionality, but rather measure the concentration of total anti-TSHR binding activity. In contrast, functional cell-based bioassays indicate whether anti-TSHR-Ab have stimulatory or blocking activity. Historically bioassays for anti-TSHR-Ab were research tools and were u…
ORBITAL PSEUDOTUMOR CAN MIMIC GRAVES’ OPHTHALMOPATHY
2016
CONTEXT: Orbital pseudotumor (OP) is a benign inflammatory process of the orbit with a large polymorphous lymphoid infiltrate, associated with fibrosis in variable amounts, localized or diffuse. Graves’ ophthalmopathy (GO) is the most common cause of proptosis, unilateral or bilateral. CASE REPORT: We report a patient with unilateral proptosis who was initially treated with antithyroid drugs for an euthyroid Graves disease, but the extension of the investigation infirmed this. The MRI findings (inflammation of fat, muscle and the left lacrimal gland) in conjunction with the biopsy infirmed the initial diagnostic and confirmed the OP. CONCLUSIONS: Orbital pseudotumor is a rare disorder that …
Possible Pathogenetic Relevance of Interleukin-1beta in "Destructive" Organ-specific Autoimmune Disease (Hashimoto's Thyroiditis)
1999
Thyroid follicular cells (TFC) abundantly express a variety of immunologically relevant surface molecules in Hashimoto's thyroiditis (HT), for example, MHC antigens and adhesion molecules such as ICAM-1. Cytokines produced by infiltrating type 1 helper and cytotoxic T cells are importantly involved in de novo expression or up-regulation of such molecules. We recently demonstrated that TFC from HT patients almost invariably bear on their surface two additive functional molecules: Fas/Apo1/CD95, an important participant in apoptosis, and B7.1, a member of a family of "co-stimulatory" molecules that are crucial for efficient antigen presentation. To date, 12 out of 14 surgical HT thyroid speci…
Le cimetière du second âge du Fer de Lailly au-delà de l'eau (Yonne) : découvertes anciennes et fouilles récentes
2023
Die Nekropole von Lailly Au-delà de l’Eau (Departement Yonne) war 1927 entdeckt worden und wurde1934, 1936 und 1937 und zum letzten Mal 2012 teilweise ausgegraben. Die Untersuchung der in den Depots der Museen von Senswiederentdeckten Grabbeigaben und die systematische Aufarbeitung der Grabungsarchive der Société archéologique de Sens habenes ermöglicht, einen Teil der geschlossenen Fundkontexte zu rekonstruieren und eine Belegungschronologie dieser kleinen Nekropolevorzuschlagen, deren großes wissenschaftliches Potenzial noch in situ erforscht werden muss. Die Studie der Grabsitten hat es zudemerlaubt, die Funde in den regionalen und überregionalen soziokulturellen Kontext zu einzuordnen
HLA Class II Differentiates Between Thyroid and Polyglandular Autoimmunity.
2015
The HLA class II genes are susceptibility genes for autoimmune endocrine diseases; however, scarce data are available pertaining to the determinants of genetic susceptibility to polyglandular autoimmunity (PGA). A total of 300 consecutive and unselected patients with either PGA or monoglandular autoimmune thyroid disease (AITD) and 100 healthy control subjects were genotyped for the HLA class II DRB1, -DQA1, and -DQB1 alleles. Compared to patients with AITD and controls, the HLA-DRB1*03 (pc =0.001), *04 (pc<0.001), -DQA1*03 (pc<0.001), and -DQB1*02 (pc =0.001) alleles were increased in patients with PGA. When dividing patients with Hashimoto's thyroiditis (HT) into those with PGA (PGA-HT) v…
Influence of abiotic environmental factors on Pelargonium graveolens growth
2018
Ekstrakty pozyskiwane z roślin były używane, zwłaszcza w medycynie naturalnej, już od czasów antycznych. Przeprowadzono wiele badań, które dowodzą różnokierunkowych właściwości olejków eterycznych. Ten pozyskiwany z Pelargonium graveolens jest jedną z najbardziej cenionych substancji dla różnych gałęzi przemysłu, takich jak: kosmetyczna, mydlarska, perfumeryjna, aromaterapeutyczna, spożywcza czy medyczna. P. graveolens należy do rodziny Geraniaceae i zawiera około 280 gatunków różniących się morfologią i wyglądem zewnętrznym. Bylina ta jest krzewem sięgającym 1,3 m wysokości i ok. 1 m szerokości. Jest rodzima dla regionu Cape w południowej Afryce, natomiast została rozpowszechniona na więks…
Computation of flow velocity in gravel bed channels
2002
Accurate estimate of flow-velocity profile is of crucial importance both for scientific purposes and for solving numerous engineering problems that include, among others, sediment transport, contaminant transport, flow resistance evaluation. This paper presents a new empirical equation to represent the vertical velocity profile. The proposed equation is essentially a modified form of the well-known logarithm law of the wall and contains three parameters having a clear physical meaning. The applicability of the equation and its accuracy assessment for different hydraulic conditions, including non-uniform conditions, is verified by using experimental data obtained by different sources. The va…